Impact of environmental enrichment on heroin-induced neuroadaptations in the insula, nucleus accumbens and ventral tegmental area [0.03%]
环境富养对阿片类毒品成瘾相关脑区适应性变化的影响研究
Ewa Galaj,Apoorva Vashisht,Anjali Mangal et al.
Ewa Galaj et al.
The ventral tegmental area (VTA), nucleus accumbens (NAc) and insular cortex (IC) are brain regions implicated in addiction. However, the involvement of heroin-induced neuroadaptations in these regions is not fully uncovered. Here, we used ...
Activation of a Locus Coeruleus to Ventral Tegmental Area Noradrenergic Pathway Blunts Binge-Like Ethanol Intake and Promotes Aversive Unconditioned Responses in TH-ires-Cre Mice [0.03%]
激活黑质网状部到中脑腹侧被盖区 noradrenergic 轴突投射减少聚众饮酒行为并促进无条件厌恶反应：在TH-ires-Cre 小鼠中的研究
Caryssa R Drinkuth,Ana Paula S Dornellas,Montserrat Navarro et al.
Caryssa R Drinkuth et al.
Ethanol comprises innately aversive properties that may act as a deterrent to overconsumption. We have previously found that chemogenetic activation or inhibition of a noradrenergic locus coeruleus (LC) to rostromedial tegmental nucleus (RM...
NADPH Exerts Neuroprotection in Ischemic Stroke by Reinforcing Blood-Brain Barrier Integrity and Stimulating Angiogenesis [0.03%]
NADPH通过增强血脑屏障完整性和促进血管生成在缺血性卒中中发挥神经保护作用
Hui Xu,Hua Zhang,Rui-Rui Shi et al.
Hui Xu et al.
Ischemic stroke (IS) represents a significant global health burden with increasing incidence, creating an urgent need for novel therapeutic approaches. This study explored the neuroprotective effects of nicotinamide adenine dinucleotide pho...
Sex-dependent disruption of affective behaviors by GBR 12909: relevance to bipolar disorders [0.03%]
GBR 12909对情感行为的性别依赖性干扰及其与双相情感障碍的关系
Maelle Certon,Bruno Brizard,Catherine Belzung et al.
Maelle Certon et al.
Bipolar disorders (BD) are defined by a chronic recurrence of manic and depressive phases. Along with mood, acute phases are associated with altered emotions. The biological underpinnings of these changes are unresolved, mostly because mode...
Discovery of a novel IMS48 as a dual inhibitor of acetylcholinesterase and butyrylcholinesterase: In vitro and in vivo study for Alzheimer Therapy [0.03%]
一种新型的IMS48化合物作为乙酰胆碱酯酶和丁酰胆碱酯酶双效抑制剂的研究：体内外实验及阿尔茨海默症治疗研究
Samman Munir,Zunera Chaudhary,Imran Ahmad Khan et al.
Samman Munir et al.
Current medications for Alzheimer's disease (AD) provide symptomatic relief only and fail to prevent neurodegeneration, necessitating the development of new therapeutic agents. This study aimed to evaluate benzimidazole (BIM) analogues as p...
Sevoflurane, but not alphaxalone, causes lasting autism spectrum disorder-like pathology in male mice after exposure occurs during synaptogenesis [0.03%]
异氟醚而非 alphaxalone 在突触发生期间接触后会引起小鼠持久的自闭症光谱障碍样病理损伤
Benjamin Volvovitz,Adre Newson,Andjelko Milosevic et al.
Benjamin Volvovitz et al.
Background and purpose: Early-life general anesthesia (GA) may cause changes in socio-emotional behaviors in animals and autism spectrum disorder (ASD) in humans. The mechanisms behind GA-induced ASD symptoms are unknown....
Pharmacological modulation of wakefulness and extracellular hypothalamic histamine release in adult male mice using TAK-925, modafinil, pitolisant, MK-8133 and Lu AF11167 [0.03%]
使用TAK-925、阿德拉、Pitolisant、MK-8133和Lu AF11167药理调节成年雄性小鼠的清醒状态及下丘脑外液组胺释放的研究
Camille G Hviid,Gunnar Sørensen,Birgitte R Kornum et al.
Camille G Hviid et al.
Histamine is a key regulator of wake and arousal, however its role in pharmacological modulation of wake is largely unknown. Specifically, whether histamine is always activated during pharmacologically induced wake promotion or even necessa...
Fentanyl reinforcement history has sex-specific effects on multi-step decision-making [0.03%]
芬太尼的强化历史对多步决策有性别特异性的效果
Eric Garr,Yifeng Cheng,Andy Dong et al.
Eric Garr et al.
It is commonly thought that drug addiction involves a transition to habitual control of action, where the choice to consume drugs becomes automatized and reflects a failure to deliberate over possible negative outcomes. Determining whether ...
The potent and selective adenosine A2AR antagonists P400 and P625 protect against symptoms in autoimmune experimental encephalomyelitis by attenuating neuroinflammation and demyelination [0.03%]
新型抗炎小分子化合物P400和P625对自身免疫性脑脊髓炎的保护作用及机制研究
M Morozzi,V Borgonetti,C Sasia et al.
M Morozzi et al.
Multiple sclerosis (MS) is an autoimmune chronic inflammatory disease of the central nervous system characterized by oxidative stress, demyelination, and neuronal damage. Current MS therapies are unsatisfactory and new therapies are encoura...
Adolescent cannabinoid vapour exposure sex-dependently alters the relationship between vulnerability traits and ethanol self-administration and modifies naltrexone actions on ethanol intake in rats [0.03%]
青春期大麻素气溶胶暴露性别依赖性地改变了易感特征与酒精自给之间的关系，并且会改变纳曲酮对酒精摄入的作用
Jairo S Acosta-Vargas,Natalia de Las Heras-Martínez,Alberto Marcos et al.
Jairo S Acosta-Vargas et al.
Cannabis use during adolescence is common and may predispose individuals to substance use disorders. Animal studies have explored the gateway hypothesis, but data on ethanol consumption are limited. This study aimed to investigate the poten...