An integrated computational framework for hazard identification of emerging contaminants: a case study of 6PPD [0.03%]
一种用于新兴污染物危害识别的集成计算框架：以6PPD为例的研究
Tingting Ding,Linghao Meng,Yahui Zhang et al.
Tingting Ding et al.
With the rapid expansion in the diversity and production of chemical, the associated environmental pollution and health risks have become increasingly prominent, underscoring the urgent need for rapid identification of potential high-risk c...
FOXA1 protects against PM2.5-induced chronic lung injury via MARCHF8-dependent mitophagy inhibition [0.03%]
FOXA1通过MARCHF8依赖的线粒体自噬抑制来保护PM2.5引起的慢性肺损伤
Xu Wu,Lingfeng Liu,Dafei Wei et al.
Xu Wu et al.
The function and mechanism of the E3 ubiquitin ligase membrane-associated ring-CH-type finger 8 (MARCHF8) in fine particulate matter (PM2.5)-induced lung injury remain unknown. The effect of MARCHF8 overexpression on PM2.5-induced lung inju...
Perinatal exposure to nonylphenol reprograms hepatic clock machinery and energy metabolism in rat offspring [0.03%]
孕期壬基酚暴露重编程大鼠子代肝脏生物钟机制和能量代谢
Bingcheng Cai,Jinghui Qu,Dianqi Yao et al.
Bingcheng Cai et al.
Disturbances in energy metabolism during developmental periods have long-term health consequences. Notably, the effects of perinatal exposure to nonylphenol (NP), a ubiquitous environmental contaminant, on energy metabolism remain unclear. ...
PFAS exposure modulates mitochondrial susceptibility in steatotic hepatocytes [0.03%]
PFAS暴露可调节脂肪变性肝细胞中的线粒体易感性
João Marcos G Barbosa,Andi Alijagic,Anh Hoang Nguyen et al.
João Marcos G Barbosa et al.
Per- and polyfluoroalkyl substances (PFAS) are highly persistent environmental pollutants that bioaccumulate in living organisms and are increasingly implicated in metabolic dysfunction-associated steatotic liver disease (MASLD). Mitochondr...
GRADE concept article: Evaluating risk of bias in a body of evidence from studies of environmental and other exposures [0.03%]
分级理念文章：评估环境和其他暴露证据体的研究偏倚风险
Elizabeth G Radke,Suril S Mehta,Krista Y Christensen et al.
Elizabeth G Radke et al.
Introduction: Evaluating the impact of bias in observational epidemiology studies is critical to systematic reviews in public health (as is the case with any study type). However, researchers have expressed concern that u...
Association of vehicle emission charging zones with adult emergency hospital admissions: an interrupted time series analysis of the toxicity charge and Ultra Low Emission Zone in London, UK [0.03%]
英国伦敦毒性和超低排放区收费与成人急诊住院的关系：时间序列分析
Rosemary C Chamberlain,John Hodsoll,Chang Cai et al.
Rosemary C Chamberlain et al.
Background: The Toxicity Charge (T-charge) introduced in 2017 in central London, and Ultra-Low Emission Zone (ULEZ) which replaced it in 2019, are vehicle emission-based charging schemes introduced to reduce urban air pol...
Effects of phthalate metabolite mixture exposure on mouse oocyte development [0.03%]
酞酸酯代谢物混合暴露对小鼠卵母细胞发育的影响
Juan Dong,Vidhi Patel,Shuangqi Wang et al.
Juan Dong et al.
Phthalates are pervasive endocrine-disrupting chemicals widely used in consumer products. The wide use of many phthalates results in chronic human exposure to complex mixtures rather than single compounds. Despite extensive studies on indiv...
Immunomodulatory effects of Bisphenol A, perfluorooctanoic acid, and tris(1,3-dichloro-2-propyl) phosphate on THP-1-derived macrophages [0.03%]
双酚A、全氟辛酸和三(1,3-二氯-2-丙基)磷酸盐对THP-1衍生的巨噬细胞免疫调节作用的影响
Oscar Sabuz,Jordi Blanco,Deepika Deepika et al.
Oscar Sabuz et al.
Endocrine-disrupting chemicals (EDCs) are widespread environmental contaminants known to interfere with hormonal and immune functions. Among these, Bisphenol A (BPA), tris(1,3-dichloro-2-propyl) phosphate (TDCPP), and perfluorooctanoic acid...
Early-life triphenyl phosphate (TPhP) exposure impairs the zebrafish dopaminergic system and elevates parkinsonian-like neurotoxicity risk [0.03%]
早期三苯基磷酸酯(TPhP)暴露损害斑马鱼多巴胺能系统并增加帕金森氏症样神经毒性风险
Dinghui Wang,Congying Luo,Xingbo Wang et al.
Dinghui Wang et al.
Triphenyl phosphate (TPhP) is a widely used organophosphate flame retardant with disproportionate exposure burdens in infants and toddlers, yet its potential to programme later-life neurodegenerative susceptibility remains unclear. We expos...
Integrative network toxicology and multi-omics analyses reveal divergent molecular programs underlying pyrethroid-induced ovarian dysfunction [0.03%]
整合的网络毒理学和多组学分析揭示了拟除虫菊酯诱导卵巢功能障碍的分子程序不同的分子机制
Yinxue Wang,Feng Deng,Yongjin Luo et al.
Yinxue Wang et al.
Pyrethroid insecticides are among the most widely used insecticide classes worldwide, and low-level exposure is common in the general population. Although previous studies have implicated pyrethroid exposure in ovarian dysfunction, whether ...