Kathryn G Commons
Kathryn G Commons
Effects of citalopram on serotonin and CRF systems in the midbrain of primates with differences in stress sensitivity [0.03%]
氟西汀对灵长类压力敏感性差异下脑干5-HT和CRF系统的影响
Cynthia L Bethea,Fernanda B Lima,Maria L Centeno et al.
Cynthia L Bethea et al.
This chapter reviews the neurobiological effects of stress sensitivity and s-citalpram (CIT) treatment observed in our nonhuman primate model of functional hypothalamic amenorrhea (FHA). This type of infertility, also known as stress-induce...
Sadao Shiosaka,Yasuyuki Ishikawa
Sadao Shiosaka
Accumulating evidence has suggested pivotal roles for neural proteases in development, maturation, aging, and cognitive functions. Among such proteases, neuropsin, a kallikrein gene-related (KLK) endoprotease, appears to have a significant ...
Upregulation of select rab GTPases in cholinergic basal forebrain neurons in mild cognitive impairment and Alzheimer's disease [0.03%]
轻度认知障碍和阿尔茨海默病患者胆碱能基底前脑神经元中某些RAB GTP酶的上调表达
Stephen D Ginsberg,Elliott J Mufson,Melissa J Alldred et al.
Stephen D Ginsberg et al.
Endocytic system dysfunction is one of the earliest disturbances that occur in Alzheimer's disease (AD), and may underlie the selective vulnerability of cholinergic basal forebrain (CBF) neurons during the progression of dementia. Herein we...
Comparative Study
Journal of chemical neuroanatomy. 2011 Oct;42(2):102-10. DOI:10.1016/j.jchemneu.2011.05.012 2011
Martin Parent,Marie-Josée Wallman,Dave Gagnon et al.
Martin Parent et al.
This review paper summarizes our previous contributions to the study of serotonin (5-hydroxytryptamine; 5-HT) innervation of basal ganglia in human and nonhuman primates under normal conditions. We have visualized the 5-HT neuronal system i...
Collateralized dorsal raphe nucleus projections: a mechanism for the integration of diverse functions during stress [0.03%]
边缘侧网状核投射的担保作用：应激过程中整合多种功能的机制
Maria Waselus,Rita J Valentino,Elisabeth J Van Bockstaele
Maria Waselus
The midbrain dorsal raphe nucleus (DR) is the origin of the central serotonin (5-HT) system, a key neurotransmitter system that has been implicated in the expression of normal behaviors and in diverse psychiatric disorders, particularly aff...
From progenitors to integrated neurons: role of neurotransmitters in adult olfactory neurogenesis [0.03%]
从干细胞到成熟神经元：神经递质在成人嗅球神经发生中的作用
Serena Bovetti,Simona Gribaudo,Adam C Puche et al.
Serena Bovetti et al.
Adult neurogenesis is due to the persistence of pools of constitutive stem cells able to give rise to a progeny of proliferating progenitors. In rodents, adult neurogenic niches have been found in the subventricular zone (SVZ) along the lat...
Functional organization of the dorsal raphe efferent system with special consideration of nitrergic cell groups [0.03%]
背缝纹核投射的功能性神经组织的特殊考虑——含一氧化氮的细胞群
Rani K Vasudeva,Rick C S Lin,Kimberly L Simpson et al.
Rani K Vasudeva et al.
The serotonin (5HT) system of the brain is involved in many CNS functions including sensory perception, stress responses and psychological disorders such as anxiety and depression. Of the nine 5HT nuclei located in the mammalian brain, the ...
Development by environment interactions controlling tryptophan hydroxylase expression [0.03%]
环境与发育相互作用调控色氨酸羟化酶的表达
Matthew W Hale,Anantha Shekhar,Christopher A Lowry
Matthew W Hale
Tryptophan hydroxylase is the rate-limiting enzyme in the biosynthesis of serotonin (5-hydroxytryptamine; 5-HT). Two isoforms of tryptophan hydroxylase, derived from different genes, tph1 and tph2, have been identified. The tph1 isoform is ...
The serotonergic anatomy of the developing human medulla oblongata: implications for pediatric disorders of homeostasis [0.03%]
发育中人的延髓血清素解剖学：对儿童稳态障碍的启示
Hannah C Kinney,Kevin G Broadbelt,Robin L Haynes et al.
Hannah C Kinney et al.
The caudal serotonergic (5-HT) system is a critical component of a medullary "homeostatic network" that regulates protective responses to metabolic stressors such as hypoxia, hypercapnia, and hyperthermia. We define anatomically the caudal ...