Network pharmacology analysis and experimental validation to explore the effect and mechanism of tetramethylpyrazine for spinal cord injury [0.03%]
网络药理学分析及实验验证研究四甲基吡嗪对脊髓损伤的作用和机制
Guodong Qi,Shujun Li,Qiong Jiang et al.
Guodong Qi et al.
Objective: To investigate the effect and mechanism of Tetramethylpyrazine (TMP) in treating Spinal Cord Injury (SCI) using network pharmacology analysis and animal experiments. ...
Neurobehavioral deficits, histoarchitectural alterations, parvalbumin neuronal damage and glial activation in the brain of male Wistar rat exposed to Landfill leachate [0.03%]
接触垃圾渗滤液的Wistar雄性大鼠大脑中存在神经行为缺陷，组织构象改变，游离钙结合蛋白神经元损伤和胶质激活
Usende Ifukibot Levi,Mofio M Bintu,Osinachi Chinonyerem Daniella et al.
Usende Ifukibot Levi et al.
Concerns about inappropriate disposal of waste into unsanitary municipal solid waste landfills around the world have been on the increase, and this poses a public health challenge due to leachate production. The neurotoxic effect of Gwagwal...
Icariin attenuates dopaminergic neural loss in haloperidol-induced Parkinsonism in rats via GSK-3β and tyrosine hydroxylase regulation mechanism [0.03%]
槐花二萜通过GSK-3β和酪氨酸羟化酶调节机制减轻由氟哌啶醇所致的帕金森大鼠多巴胺能神经损失
Hend A Sabry,Mai M Zahra
Hend A Sabry
Parkinson's Disease (PD) is an age-dependent, incessant, dynamic neurodegenerative illness. In animal models, the administration of the dopaminergic D2 antagonist Haloperidol (HP) affects the nigrostriatal pathway, inducing catalepsy, a sta...
Rehabilitation training enhanced the therapeutic effect of calycosin on neurological function recovery of rats following spinal cord injury [0.03%]
康复训练增强川芎嗪对脊髓损伤大鼠神经功能恢复的治疗效果
Mingdong Li,Yanqiang Huan,Tianqi Jiang et al.
Mingdong Li et al.
Background: Calycosin (CA), a flavonoids component, has demonstrated potential neuroprotection effects by inhibiting oxidative stress in spinal cord injury (SCI) models. This study aims to investigate the impact of combin...
Solifenacin promotes remyelination in cuprizone mouse model by inhibiting the Wnt/β-catenin signaling pathway [0.03%]
索利那新通过抑制Wnt/ β -catenin信号通路促进铜吡啶小鼠模型的少突胶质细胞重建髓鞘的过程
Xinqi Xu,Xueli Song,Fei Chen et al.
Xinqi Xu et al.
Demyelinating diseases are a type of neurological disorder characterized by the damage to the myelin sheath in the central nervous system. Promoting the proliferation and differentiation of oligodendrocyte precursor cells (OPCs) is crucial ...
Electroacupuncture protects against the striatum of ischemia stroke by inhibiting the HMGB1/RAGE/p-JNK signaling pathways [0.03%]
电针通过抑制HMGB1/RAGE/p-JNK信号通路保护缺血性卒中的纹状体
Zeyin Nie,Chenying Hu,Huachun Miao et al.
Zeyin Nie et al.
The striatum (Str) is injured 20 min after permanent ischemic stroke, leading to neurological deficits. Here, we aimed to explore the effect of electroacupuncture (EA) on ischemic stroke and elucidate the possible underlying mechanism. Rat ...
Coenzyme Q10 attenuates neurodegeneration in the cerebellum induced by chronic exposure to tramadol [0.03%]
辅酶Q10减轻慢性曲马多暴露引起的 cerebellum神经退行性变
Majid Keyhanifard,Roghayeh Javan,Reza Ataee Disfani et al.
Majid Keyhanifard et al.
Background: Chronic use of tramadol can cause neurotoxic effects and subsequently cause neurodegeneration in the cerebellum. The main damage mechanisms identified are oxidative stress and inflammation. Currently, we inves...
Supplementation with vitamins D3 and a mitigates Parkinsonism in a haloperidol mice model [0.03%]
维生素D3和α姜黄素补充剂可减轻氟哌啶醇诱导的小鼠帕金森症状
Mujittapha Umar Sirajo,John C Oyem,Mohammed Ibrahim Badamasi
Mujittapha Umar Sirajo
Background: Earlier reports suggest that vitamin D3 (Vit D3) supplementation attenuates Parkinsonism in drug-induced motor deficits. Moreover, the function of Vit D3 may be optimized by co-administration with vitamin A (V...
Aqueous leaf extract of Phyllanthus amarus protects against oxidative stress and misfiring of dopaminergic neurons in Paraquat-induced Parkinson's disease-like model of adult Wistar rats [0.03%]
运用大鼠帕金森病样模型研究amarus叶提取物水溶液对其氧化应激和多巴胺能神经元误放电的保护作用
Felix U Enemali,Kingsley Afoke Iteire,Raphael E Uweigho et al.
Felix U Enemali et al.
Background of the study: Phyllanthus amarus has high nutritional value and is beneficial in managing and treating diverse ailments. This study assessed the role of aqueous leaf extract of Phyllanthus amarus on Paraquat (P...
Gallic acid ameliorates behavioral dysfunction, oxidative damage, and neuronal loss in the prefrontal cortex and hippocampus in stressed rats [0.03%]
没食子酸通过改善氧化损伤和海马及前额叶皮质神经元丢失干预压力所致的行为异常
Gholam Hossein Meftahi,Nahid Aboutaleb
Gholam Hossein Meftahi
Gallic acid (GA) is known to be a natural phenolic compound with antioxidant and neuroprotective effects. This study aims to investigate the impact of GA against restraint stress-induced oxidative damage, anxiety-like behavior, neuronal los...