Parallel sample processing for mass spectrometry-based single cell proteomics [0.03%]
基于质谱的单细胞蛋白质组学的并行样品处理方法研究
Jing Wang,Bo Xue,Olanrewaju Awoyemi et al.
Jing Wang et al.
Background: Single cell mass spectrometry (scMS) has shown great promise for label free proteomics analysis recently. To present single cell samples for proteomics analysis by MS is not a trivial task. Existing methods re...
Melt-blown polypropylene nonwoven as an efficient and eco-economic sorbent for pipette tip micro-solid phase extraction for the determination of tyrosine kinase inhibitors [0.03%]
用于酪氨酸激酶抑制剂测定的移液管吸头微固相萃取的高效经济型熔喷聚丙烯非织造布吸附材料
Jing Ye,Yuanyuan Zheng,Xiangyu Li et al.
Jing Ye et al.
Background: The detection of tyrosine kinase inhibitors (TKIs) in biological fluids is essential due to their critical role in cancer therapy and the variability in individual drug metabolism, which necessitates precise d...
A 96-position platform for magnetic sorbent-based dispersive microextraction: Application to the determination of tetrahydrocannabinol and cannabidiol in saliva of cannabis smokers [0.03%]
一种用于磁性吸附分散式微萃取的96位平台：应用于吸食大麻者唾液中四氢大麻酚和大麻二酚测定的方法
Cristian Azorín,Juan L Benedé,Alberto Chisvert
Cristian Azorín
Background: In order to obtain sustainable analytical methods, it is essential to develop kinetically efficient sample preparation strategies in which equilibria are reached faster, as dispersive extraction techniques. In...
Ultrasensitive mass spectrometric quantitation of apurinic/apyrimidinic sites in genomic DNA of mammalian cell lines exposed to genotoxic reagents [0.03%]
体外暴露于致突变试剂的哺乳动物细胞系基因组DNA中碱基切除修复起始点的超灵敏定量分析
Chen-Yu Xue,Ya-Hong Liu,Yue Yu et al.
Chen-Yu Xue et al.
The apurinic/apyrimidinic (AP) site is an important intermediate in the DNA base excision repair (BER) pathway, having the potential of being a biomarker for DNA damage. AP sites could lead to the stalling of polymerases, the misincorporati...
Microplasma-induced in situ rapid synthesis of CoSe nanosphere@N-doped polymeric carbon dots derived from ZIF-67 for highly sensitive dopamine detection [0.03%]
微等离子体诱导的ZIF-67衍生的CoSe纳米球@N掺杂聚合物碳点的原位快速合成用于高灵敏检测多巴胺
Lin Zhang,Junchun Guo,Ming Yuan et al.
Lin Zhang et al.
Background: Designing a fast and sensitive electrochemical sensing platform to achieve selective quantitative detection of dopamine (DA) is a great challenge. Combining transition metal selenides (TMSs) with a variety of ...
Fluorogenic target competitors for developing label-free and sensitive folding-unswitching aptamer sensors [0.03%]
荧光竞争探针用于开发无标记折叠转换型适配体传感器
Xingli Zeng,Xiufang Tong,Jiahui Chen et al.
Xingli Zeng et al.
Background: Aptamers have aroused tremendous applications in sensors, drug deliveries, diagnosis, and therapies. In particular, target-induced global structure switching of aptamers has been widely used to develop selecti...
LC-MS simultaneous profiling of acyl-CoA and acyl-carnitine in dynamic metabolic status [0.03%]
基于LC-MS的酰基辅酶A和酰基肉毒碱的同时分析及其在动态代谢状态下的应用研究
Jiangang Zhang,Juan Lei,Xudong Liu et al.
Jiangang Zhang et al.
The integration platform for exosome capture and colorimetric detection: Site occupying effect-modulated MOF-aptamer interaction and aptamer-Au NPs-dopamine interaction [0.03%]
一种基于MOF-适配体和适配体-AuNPs-多巴胺相互作用的外泌体捕获及比色检测集成平台：位点占领效应调控机制
Jingjing Kuang,Linghao Zhao,Shengli Ruan et al.
Jingjing Kuang et al.
Exosomes are extracellular vesicles of 30-200 nm in diameter that inherit molecular markers from their parent cells, including proteins, lipids, nucleic acids, and glycoconjugates. The detection and protein profiling of exosome could provid...
Integrating lateral flow device with controllable gold in situ growth for sensitive detection of staphylococcal enterotoxin A in milk [0.03%]
可控金纳米粒子原位生长的侧流试纸条用于牛奶中金黄色葡萄球菌肠毒素A的检测
Hong Duan,Lirong Zhao,Jiali Wang et al.
Hong Duan et al.
Gold nanoparticle-based lateral flow immunoassays (AuNP-LFIA) are widely used for pathogen monitoring to prevent foodborne illness outbreaks. However, conventional AuNP-LFIA exhibits poor sensitivity and limited quantitative capacity due to...
Photoelectron-transfer-effect grafting: Validation of a generalized strategy for fluorescence and photoelectrochemical dual-mode detection of hydrogen sulfide [0.03%]
基于光电子转移效应的接枝反应：用于检测硫化氢荧光和光电化学双模式传感器通用策略的验证
Xiao-Jie Yu,Xiao-Yan Wan,Yu-Ting Shen et al.
Xiao-Jie Yu et al.
Background: The progress of modern research is constantly fueled by the convergence of multiple technologies. Despite the enormous potential of both fluorescence (FL) and photoelectrochemical (PEC) technologies, the devel...