Towards the non-invasive determination of estradiol levels: Development and validation of an LC-MS/MS assay for quantification of salivary estradiol at sub-pg/mL level [0.03%]
向非侵入性雌二醇水平测定迈进：开发和验证一种在皮克/毫升以下水平定量唾液雌二醇的LC-MS/MS测定方法
David Fabregat-Safont,Élida Alechaga,Noemí Haro et al.
David Fabregat-Safont et al.
Background: Estradiol (E2) is a female sex hormone involved in several biological processes. Although E2 levels are commonly measured in blood samples, the use of non-invasive techniques (e.g. determination of salivary E2...
Mass-tagged self-assembled nanoprobe reveals the transport of PD-L1 from cancer cells to tumor-educated platelets [0.03%]
基于群体标签的纳米探针自组装成像技术示癌症细胞PD-L1向肿瘤教育血小板转运现象
Jianhua Zhu,Wenjun Zhang,Zhongcheng Wang et al.
Jianhua Zhu et al.
Background: The expression level of immune checkpoint proteins detected by tissue biopsy is currently used as a predictive biomarker for immune checkpoint blockade (ICB) therapy. However, tissue biopsy is susceptible to i...
Comparative evaluation of accuracy in near-infrared and Raman spectroscopic determinations of component concentration in packed solid mixtures under various packing densities [0.03%]
不同堆积密度下的近红外和拉曼光谱法测定固相混合物中组分浓度的准确性比较评价研究
Haeseong Jeong,Seung Jee Yang,Jomjai Peerapattana et al.
Haeseong Jeong et al.
Background: Physical characteristics of packed samples, such as packing density, influence subsequent near-infrared (NIR) and Raman spectral features. This potential decrease in accuracy is a concerning issue in practical...
A highly specific two-photon fluorescent probe for real-time monitoring of acetylcholinesterase in neurogenic disorders in vivo [0.03%]
一种高特异性双光子荧光探针用于活体神经性疾病乙酰胆碱酯酶实时监测
Weizhen An,Zhongxi Huang,Wei Jiang et al.
Weizhen An et al.
Acetylcholinesterase (AChE) hydrolyses choline into thiocholine, which is essential for cholinergic neurons to revert to their resting state following activation. Abnormal changes in AChE activity can directly affect nervous system function...
"Explosive" CaCO3 microcapsules driven by EDTA combined with a "signal booster" semiconductor Zn0.995Ce0.005O SERS substrate for ultra-sensitive SERS detection of chloramphenicol [0.03%]
“信号放大”半导体Zn0.995Ce0.005O与乙二胺四乙酸驱动的“爆炸式”CaCO3微胶囊增强氯霉素表面增强拉曼散射超灵敏检测
Runzi Zhang,Shunbi Xie,Qianyan Zhang et al.
Runzi Zhang et al.
Background: Chloramphenicol (CAP) is a broad-spectrum antibiotic, and its continuous use in human medicine, livestock has resulted disturbances in ecosystem stability. The complex background and low concentration of CAP i...
Optimization of complexing membranes for platinum analysis in water at part per trillion levels by X-ray fluorescence [0.03%]
X射线荧光法测定水体中痕量铂的复合膜优化研究
Georgia P Vlamaki,Nikolaos G Kallithrakas-Kontos
Georgia P Vlamaki
Background: Platinum is a critical metal, especially in medicine and catalysis. Its concentration in aquatic ecosystems may gradually affect aquatic animals due to its ability to bioaccumulate. Additionally, the recycling...
Intensity- and time-based strategies for micro/nano-sizing via single-particle ICP-mass spectrometry: A comparative assessment using Au and SiO2 as model particles [0.03%]
基于强度和时间的策略用于微/纳米粒化并通过单粒子ICP-MS进行比较评估：以Au和SiO2作为模型颗粒
Antonio Bazo,Eduardo Bolea-Fernandez,Ana Rua-Ibarz et al.
Antonio Bazo et al.
Background: Single-particle ICP-mass spectrometry (SP-ICP-MS) is a powerful method for micro/nano-particle (MNP) sizing. Despite the outstanding evolution of the technique in the last decade, most studies still rely on tr...
Development of an accurate synchronous transport signal hand-held sensing platform for fluorescence-based berberine on-site detection [0.03%]
一种基于荧光的巴马汀现场检测准同步传输信号便携式传感平台的研究开发
Liucheng Guo,Liyue Du,Yan Zhang et al.
Liucheng Guo et al.
Background: Berberine is widely used in clinical treatment because of its wide antibacterial spectrum and low toxic side effects. However, its abuse could lead to bacterial resistance and several other adverse effects. In...
Optical fiber fluorescence Cu2+ sensing technology based on CdSe/ZnS quantum dots: Large detection range, low detection limit [0.03%]
基于CdSe/ZnS量子点的光纤荧光Cu²⁺检测技术：检测范围广、检出限低
Ya-Nan Zhang,Wenchao Liang,Like Li et al.
Ya-Nan Zhang et al.
Background: Copper ion (Cu2+), a crucial heavy metal ion, is closely associated with human health and the ecological environment. Imbalances in Cu2+ can result in health issues for humans and damage to the ecosystem. Ther...
Characterization of monoclonal antibody charge variants under near-native separation conditions using nanoflow sheath liquid capillary electrophoresis-mass spectrometry [0.03%]
基于纳米流路鞘液毛细管电泳质谱的单克隆抗体电荷异构体表征研究
Annika A M van der Zon,Alisa Höchsmann,Tijmen S Bos et al.
Annika A M van der Zon et al.
Background: Monoclonal antibodies (mAbs) undergo multiple post-translational modifications (PTMs) during production and storage, resulting for instance in charge and oxidized variants. PTMs need to be assessed as critical...