Autocatalytic DNA nanosphere assembly activated by endogenous APE1 for intracellular miR-21 imaging [0.03%]
一种基于细胞内源APE1激活的DNA纳米球组装体系用于miR-21成像
Liuting Mo,Chunfen Zhang,Rongzheng Yuan et al.
Liuting Mo et al.
MicroRNAs (miRNAs) are promising cancer biomarkers, yet their intracellular detection remains constrained by limited amplification efficiency, nonspecific activation, and nuclease-mediated probe degradation. Here, we developed an APE1-activ...
Simultaneous profiling of phospho- and palmitoyl-proteome landscape in serum exosomes through paramagnetic separation [0.03%]
基于顺磁分离的血清外泌体磷酸化和棕榈酰化蛋白质组的同时分析
Zirui Wang,Haijiao Zheng,Cui Liu et al.
Zirui Wang et al.
Background: Protein post-translational modification (PTM) events in exosomes play a critical role in key biological processes and hold significance in the occurrence and development of diverse diseases. Thus, monitoring t...
Pyridyl ethyl diazoacetate derivatization enables LC-MS annotation of cholesterol and its metabolites [0.03%]
吡啶基乙基叠氮醋酸衍生化使胆固醇及其代谢物的LC-MS注释成为可能
Wenhao Ke,Yikang Wang,Yang Chen et al.
Wenhao Ke et al.
Cholesterol and its metabolites are fundamental to membrane organization and cellular signaling, but their poor ionization efficiency and structural similarity complicate mass-spectrometric (MS) analysis. In this work, we developed pyridyl ...
Mitochondria-targeted phosphorescent probes for Cu2+/H2S bioimaging and H2S dynamics monitoring in hepatic inflammation [0.03%]
用于肝部炎症中H2S动态监测的线粒体靶向磷光Cu2+/H2S生物成像探针
Jinbiao Wang,Xin Zhang,Xiaotong Pan et al.
Jinbiao Wang et al.
Background: Cu2+ and H2S participate in vital physiological activities, especially mitochondrial function. Endogenous H2S has served as a critical biomarker of liver injury. Accordingly, detecting Cu2+ and H2S in mitochon...
Cyanostilbene-Naphthalimide: First fluorescent probe for pesticide pyraclostrobin with high "turn-on" fluorescence response [0.03%]
氰茋-萘酰亚胺：吡唑酯类杀菌剂嘧菌酯的首个“开亮型”荧光探针
Ting Yang,Yijing Shang,Sining Zheng et al.
Ting Yang et al.
Pyraclostrobin is an important fungicide, but its excessive residue pose a significant hazard to the environment and human health. The current detecting methods for pyraclostrobin are characterized by a lack of simplicity and the inability ...
Ce, N, S co-doped carbon dots with synergistically enhanced peroxidase-like activity for glucose biosensing and ROS-mediated cytotoxic effect [0.03%]
具有协同增强的类过氧化物酶活性的Ce，N，S共掺杂碳点用于葡萄糖生物传感和ROS介导的细胞毒作用
Xinxin Xu,Junjie Li,Yutong Wu et al.
Xinxin Xu et al.
Engineering novel nanozymes with excellent catalytic activity and good biocompatibility, and exploring their multifunctional applications are crucial for the advancement of nanozyme science. Herein, we developed Ce, N, S co-doped carbon dot...
Cationic covalent organic framework with electrostatic-magnetic synergy for efficient enrichment and immunochromatography assay of Salmonella typhimurium [0.03%]
基于静电-磁协同效应的阳离子共价有机框架高效富集及三甲胺免疫层析检出沙门氏菌
Lihong Su,Lei Zhao,Shuhui Wei et al.
Lihong Su et al.
Background: Conventional lateral flow immunoassays (LFIA) for pathogen detection often suffer from insufficient sensitivity, limited anti-interference capability, and reliance on matched antibody pairs. To address these c...
Regions of interest three-way multivariate curve resolution analysis of lipid LC-IMS-MS/MS data [0.03%]
感兴趣区域的三元多重曲线解析分析方法研究脂质体LC-IMS-MS/MS数据
Chenxi Peng,Anna de Juan,Romà Tauler
Chenxi Peng
Background: Liquid chromatography-ion mobility-tandem mass spectrometry (LC-IMS-MS/MS) enables multidimensional characterization of complex lipid mixtures. However, the resulting high-dimensional datasets pose significant...
An integrated experimental and computational study on a COX-2-targeted AIE probe for precise cancer cell imaging via restriction of intramolecular rotation [0.03%]
一种COX-2靶向AIE探针的集成实验和计算研究通过限制分子内旋转实现精准癌细胞成像
Jianxi Liu,Shengfa Song,Yonglin Zhang et al.
Jianxi Liu et al.
Background: The overexpression of cyclooxygenase-2 (COX-2) and alterations in microenvironmental viscosity are recognized as pivotal hallmarks for the early diagnosis and progression of malignant tumors. Although fluoresc...
A TAPT-BTTA@MnO2-based fluorescence-colorimetric-photothermal multimodal sensing platform for reliable determination of organophosphorus pesticides [0.03%]
一种用于可靠检测有机磷农药的TAPT-BTTA@MnO2基荧光-比色-光热多模态传感平台
Suyu Li,Yuzhen Wang,Huilin Liu et al.
Suyu Li et al.
Background: Reliable determination of organophosphorus pesticides (OPs) is essential for food safety monitoring. However, most reported sensing methods rely on a single analytical signal, highlighting the need for multimo...