Ultra-trace multi-matrix LC-MS/MS determination of organophosphate flame retardants and metabolites in marine waters, sediments, and algae [0.03%]
用于海洋水体、沉积物和藻类中有机磷阻燃剂及其代谢产物的超痕量多基质LC-MS/MS分析方法
Florentina Laura Chiriac,Iuliana Paun,Florinela Pirvu et al.
Florentina Laura Chiriac et al.
Background: Organophosphate flame retardants (OPFRs) are emerging contaminants increasingly detected in marine environments due to their extensive industrial use and replacement of brominated flame retardants. Their occur...
Monolithic triple auto-enhanced DNA nanoamplifier under orthogonal dual-response of direct-lock NIR photocage and endogenous APE1 gate for high-precision biosensing in live biosystems [0.03%]
基于正交双响应的直接锁近红外光 Cage 和内源性 APE1 门的单片三重自动增强 DNA 纳米放大器用于活生物系统的高精度生物传感
Lejing Yao,Xiaoming Sun,Cheng-Yu Li
Lejing Yao
Background: DNA nanoamplifiers constructed by isothermal protease-free nucleic acid amplifications are promising for fluorescence imaging of disease biomarkers in live biosystems. However, they are still hindered by cumbe...
"Three-in-one" integrated self-powered sensor for cadmium ion detection: On-site screening, sensitive quantification, and built-in verification functions [0.03%]
“三合一”一体化自供电传感器用于镉离子检测：现场筛查、灵敏定量和内置验证功能
Xingyu Ji,Xiaojiao Du,Jun Sun et al.
Xingyu Ji et al.
Self-powered electrochemical sensors (SPES) have emerged as an eco-friendly detection technology, but reported SPES face challenges in on-site detection, quantitative sensitivity, and result credibility. To address these issues, a three-in-...
A synergy strategy of deep eutectic solvents and boric acid modified β-CD polymer for enhancing enantioseparation in HPLC [0.03%]
一种手性分离增强策略：深度吴氏溶剂与硼酸修饰的β-环糊精聚合物在HPLC中的协同应用研究
Xiaoqian Yuan,Ziyi Cheng,Jiajia Fu et al.
Xiaoqian Yuan et al.
Background: Enantiomeric separation is essential in pharmaceutical analysis because enantiomers can differ markedly in pharmacological activity, metabolism, and safety. HPLC using chiral mobile-phase additives (CMPAs), pa...
An automated dual-mode platform for affinity-based screening of natural products using a pressure-driven strategy [0.03%]
一种基于亲和力的天然产物筛选自动化双模式平台的压力驱动策略
Jingyi Jian,Kris Wolfs,Francesco Ciacci et al.
Jingyi Jian et al.
Background: Affinity-based screening is a powerful strategy for drug screening from natural products. However, conventional workflows - whether based on ultrafiltration (UF) or magnetic beads - often involve labour-intens...
Sulfobutylether-(hydroxypropyl-β-cyclodextrin) bonded silica as stationary phase for enhancing chiral separation in liquid chromatography [0.03%]
磺丁基醚-（羟丙基-β-环糊精）键合硅胶手性色谱柱的制备及评价
Linna Xu,Ankang Li,Jialong Wang et al.
Linna Xu et al.
The present study addresses the limited recognition modes and poor universality of conventional cyclodextrin-based chiral stationary phases (CSPs) by proposing a rational design strategy based on "functional group synergy" concept. Followin...
Multi-attribution characterization of metallic nanoparticles in biological media by electrical asymmetrical flow field-flow fractionation coupled to a hybrid detection platform [0.03%]
基于电气不对称流动场分析耦合混合检测平台的生物介质中金属纳米粒子的多重属性表征
Andrea López-Gutiérrez,Armando Sánchez-Cachero,Nuria Rodríguez-Fariñas et al.
Andrea López-Gutiérrez et al.
For the first time, the potential of electrical asymmetrical flow field-flow fractionation (EAF4) coupled online to a multidetector platform (UV-vis, MALS, and ICP-MS) for the comprehensive characterization of metallic nanoparticles (NPs) i...
A one-pot detection method based on restriction endonuclease recognition for rapid detection of canine parvovirus and precise genotyping of the 2c variant [0.03%]
基于限制性内切酶识别的一锅式检测方法快速检测犬细小病毒及2c型精确诊断
Liangkai Liu,Chengyao Hou,Boyan Guo et al.
Liangkai Liu et al.
Canine parvovirus (CPV) is a highly contagious virus that primarily infects dogs, posing a significant threat to canine health and wildlife conservation. Among its variants, the 2c type is the predominant circulating strain with important c...
Triply activated localized DNA circuit based on dual enzyme-guaranteed and analyte-stimulated strategy for robust tumor-cell-specific microRNA imaging [0.03%]
基于双重酶保证和分析物刺激策略的三重活化局部DNA电路用于稳健的肿瘤细胞特异性微小RNA成像
Yuanyuan Peng,Xiaoyu Wang,Wanling Cui et al.
Yuanyuan Peng et al.
Background: Localized catalytic hairpin assembly (LCHA) circuit has emerged as a potential tool for intracellular bioimaging, yet its application is limited by uncontrolled signal leakage, insufficient cell specificity, a...
Adsorption-driven SERS enhancement by Ti3C2Tx quantum dot-AuNP assembled interfaces for sensitive detection of Sudan dyes in chili powder [0.03%]
Ti3C2Tx量子点-AuNP组装界面吸附增强型SERS用于辣椒粉中苏丹染料的灵敏检测
Ruoyu Zhang,Guanghua Li,Hongwei Zhang et al.
Ruoyu Zhang et al.
Background: Sudan dyes, as illegally added food colorants, pose significant risks to human health due to their potential toxicity and carcinogenicity. Conventional chromatographic and mass spectrometric methods for Sudan ...