Determining microscopic dissociation constants of polyprotic polyphenols using NMR spectroscopy [0.03%]
利用核磁共振光谱技术确定多元酸型多元酚的离解常数
Franjo Frešer,Matja Zalar,Urban Bren et al.
Franjo Frešer et al.
Background: Protolytic equilibrium represents one of the crucial chemical features of compounds, which strongly affects their properties. The influence ranges from compound reactivity and stability to its bioavailability ...
Early insulin fibril detection: Insulin fibril research and TR structural transition detection with FRET-Probe [0.03%]
早期胰岛素纤维检测：使用FRET探针进行胰岛素纤维研究及TR结构转换检测
Morteza Malakoutikhah,Laura Kauppi,Kalle Mäntylä et al.
Morteza Malakoutikhah et al.
Background: The detection of amyloid fibrils is critical in production, storage and therapeutic use of insulin due to impact on efficacy and potential cytotoxicity after injection. Monitoring insulin aggregation, particul...
AIE-ESIPT synergistic fluorescence probe for superoxide and hypochlorite using acetoxy-substituted tetraphenyl imidazole [0.03%]
用于超氧和次氯酸根离子检测的乙酰氧基取代四苯基咪唑类AIE-ESIPT协同荧光探针
Na Yoon Kim,Maxine Mambo Fortibui,Min Hee Lee
Na Yoon Kim
Background: Reactive oxygen species (ROS) are highly reactive molecules that play pivotal roles in various cellular functions such as signaling, immune responses, and metabolic regulation. While they are essential in norm...
Central composite design-empowered colorimetric detection of levodopa by nanozyme based on tartaric acid-iridium nanoparticles: Towards visual assay by a pink color palette [0.03%]
基于酒石酸铱纳米粒子的左旋多巴中心复合设计：利用nanozyme进行颜色检测：迈向粉色调视觉测定法
Kowsar Davoodi-Rad,Ardeshir Shokrollahi,Faezeh Shahdost-Fard
Kowsar Davoodi-Rad
Background: Levodopa (L-DOPA) is a well-tolerated dopamine replacement agent and the gold standard drug in the treatment of Parkinson's disease (PD). Due to the importance of controlling concentration levels of L-DOPA for...
Dual-catalytic hairpin amplification strategy as a highly efficient signal amplifier cooperative with COF@Au for ultrasensitive SERS detection of miRNA-21 [0.03%]
双催化剂发夹结构等温放大策略与COF@Au协同用于miRNA-21超灵敏SERS检测
Runzi Zhang,Shunbi Xie,Youlin Tang et al.
Runzi Zhang et al.
Background: MicroRNAs (miRNAs) are crucial biomarkers for early disease diagnosis, but their low abundance in biological samples poses a significant challenge for detection. Surface-enhanced Raman scattering (SERS) biosen...
A colorimetric glucose sensor based on natural enzyme coupled with highly efficient nanozyme prepared by in situ reduction [0.03%]
基于天然酶与高效纳米酶原位还原构建的比色葡萄糖传感器
Tajiguli Yimamumaimaiti,Muyassar Halmurat,Munire Aimaitiniyazi et al.
Tajiguli Yimamumaimaiti et al.
Background: Colorimetric sensors based on natural enzyme-nanozyme cascade reactions are commonly employed in glucose detection owing to their high selectivity and stability. However, nanozyme synthesis often conducted und...
CBT-Cys click ligation coupled with pregnancy test strips for nucleic acid assay [0.03%]
基于“早早孕试纸”的点击化学核酸检测试条
Meiling Zhang,Jiahang Song,Huawen Zhang et al.
Meiling Zhang et al.
Background: Rolling circle amplification (RCA) is a powerful nucleic acid detection method widely used in molecular diagnosis. The circular template, which is an essential component of RCA, is typically generated via enzy...
Highly sensitive detection of miRNA-21 based on hybridization chain reaction and atom transfer radical polymerization [0.03%]
基于杂交链式反应和原子转移自由基聚合的高灵敏miRNA-21检测技术
Liang Zhou,Shuaibing Yu,Zhidan Tian et al.
Liang Zhou et al.
Background: Early cancer diagnosis is crucial for improving therapeutic outcomes and survival rates. Research in molecular oncology has shown that tumor-associated biomarkers, particularly miRNAs, are promising key indica...
Ultrasensitive SERS detection of cytokines through specific binding and multiple reporter molecules [0.03%]
通过特异性结合和多种报告分子实现细胞因子的超灵敏SERS检测技术
Hairong Chen,Hengchang Zhang,Lingfeng Duan et al.
Hairong Chen et al.
Interleukins (IL) play a vital part in molecular recognition as well as immune response, and their excessive or inappropriate production can lead to inflammatory and cardiovascular diseases, etc., which are harmful to human physical and men...
Double special bodyguard: Selenium-enhanced loop-mediated isothermal amplification combined with CRISPR/Cas12a biosensing strategy [0.03%]
双特异性保卫体系：结合CRISPR/Cas12a的富硒环介导等温扩增检测技术
Keyi Long,Tiao Han,Wenxi Hu et al.
Keyi Long et al.
Cervical cancer is closely associated with human papillomavirus (HPV) infection, underscoring the necessity for effective HPV detection. Various biosensors utilizing isothermal amplification techniques have been developed for HPV DNA detect...