A photoelectrochemical signal amplification mechanism with Exonuclease III driven stable generation of "Swing Arm" tetrahedral DNA walkers for mediating photogenerated carrier transfer [0.03%]
一种基于Exo III驱动的“摆臂”四面体DNA行走器稳定产生的光电化学信号放大机制以介导光生电荷载流子传输
Jinjie Liu,Dongquan Leng,Yu Du et al.
Jinjie Liu et al.
Background: Conventional antigen-antibody detection methods suffer from uneven antibody distribution and low target capture rates. Nevertheless, DNA offers an inherent advantage of structural tunability. By leveraging the...
Precision discrimination of single nucleotide polymorphisms via chemically engineered PNA-mediated padlock probe assembly and rolling circle amplification [0.03%]
通过化学工程PNA介导的padlock探针组装和滚环扩增精确区分单核苷酸多态性
Yang Zhao,Shuyao Wu,Xiaojun Yuan et al.
Yang Zhao et al.
Highly sensitive and specific detection of single nucleotide polymorphisms (SNPs) in genomic DNA is of great significance in disease diagnosis and personalized medicine. Here, we developed a fluorescent method for highly specific detection ...
A novel colorimetric method for nitrite detection in food based on histidine-manganese nanozyme with laccase-mimicking activity [0.03%]
一种基于类漆酶组氨酸锰纳米酶的新型硝酸盐检测方法
Xiaojuan Niu,Chunlei Wang,Tingyue Yang et al.
Xiaojuan Niu et al.
Background: Excessive nitrite in food poses a serious threat to public health. This compound not only induces methemoglobinemia by interfering with oxygen transport in the blood but also serves as a precursor to carcinoge...
Real-time in-situ H2O2 quantification in high-biomass marine environments with a robust NiCo-MOF nanosheet electrode [0.03%]
用于高生物量海洋环境的稳健NiCo-金属有机框架纳米片电极的实时原位H2O2定量研究
Dan Zhao,Yuankai Lu,Huixiu Mao et al.
Dan Zhao et al.
Background: Electrochemical sensors are widely investigated for H2O2 detection, but real-time in-situ quantification in complex biological media remains challenging. Most sensors require sample dilution or operation under...
Dual MOFs synergistically modulate electrode interface electron transfer to enhance electrochemiluminescence for ultrasensitive FB1 sensing [0.03%]
双MOF协同调节电极界面电子转移以增强电化学发光实现超灵敏FB1检测
Shuaichao Qiao,Na Song,Xue Dong et al.
Shuaichao Qiao et al.
Accurate detection of Fumonisin B1 (FB1) is of great significance for food safety and disease prevention and control. In this work, the construction of dual metal-organic frameworks (MOFs) synergistically modulated electron transfer at the ...
Design and fabrication of a dual-mode colorimetric nanobiosensor for detection of breast cancer-related microRNA biomarkers upon the simultaneous application of gold nanoparticles and DNAzyme [0.03%]
基于金纳米粒子和DNAzyme同时作用的乳腺癌相关microRNA标志物双模式比色纳生物传感器的设计与制备
Maryam Keramati,Mahdi Rahaie
Maryam Keramati
Background: Breast cancer is among the most prevalent malignancies worldwide, and early diagnosis is essential to improve treatment efficacy. In this study, we developed a dual signal colorimetric nanobiosensor for the si...
Photothermal PCR within 6 min based on pullulan-coated nanoplasmas for ultrafast nucleic acid analysis [0.03%]
一种基于葡聚糖包被的纳米等离子体6分钟内完成光热PCR的超快核酸分析方法
Yuanyuan Zhu,Sihan Ma,Jungang Du et al.
Yuanyuan Zhu et al.
Background: Photothermal PCR based on specific nanomaterials has attracted attention due to their efficient photothermal conversion. However, these nanomaterials absorb polymerases, thereby inhibiting the PCR. Owing to th...
When spectral libraries are too complex to search: Evolutionary subset selection for domain-adaptive calibration [0.03%]
当光谱库过于复杂而无法进行搜索时：用于领域自适应校正的进化子集选择方法
Leonardo Ramirez-Lopez,Raphael Viscarra Rossel,Claudio Orellano et al.
Leonardo Ramirez-Lopez et al.
Background: The increasing availability of large spectral libraries offers new opportunities to reduce the costs and efforts required to develop spectroscopy-based sensing techniques for rapidly and non-destructively esti...
Stable isotope labeling LC-MS for profiling the amine submetabolome in a D-lactate treated cell model [0.03%]
D-乳酸处理的细胞模型中的胺亚代谢组的稳定同位素标记LC-MS分析方法
Yue-Qiang Chen,Xiao-Xia Dong,Li Liu et al.
Yue-Qiang Chen et al.
Background: Alterations in the amine submetabolome are closely associated with cellular metabolic status and are important for understanding metabolic regulation under intervention conditions. In this study, a stable isot...
Multi-residue analytical method of 215 pesticides in peanut by GC-Q-Orbitrap MS/MS [0.03%]
基于GC-Q-Orbitrap MS/MS的食品中多残留农药检测方法研究
Xiaofan Qi,Sufang Fan,Lijun Han et al.
Xiaofan Qi et al.
For the analysis of pesticides in the complex, high-fat matrix of peanuts, this study developed a high-throughput screening and quantitative method for 215 pesticide residues using gas chromatography-quadrupole Orbitrap high-resolution mass...