A strip-and-read gelatin-coated paper-based analytical device for the extraction and colorimetric determination of curcumin in real food and pharmaceutical matrices [0.03%]
一种用于从真实食品和药物基质中提取和比色测定姜黄素的条形纸基分析设备
Eman A Elshenawy,Aalaa M Gnana,Amira H Kamal
Eman A Elshenawy
Background: Curcumin, a bioactive nutraceutical widely used in food, cosmetics, and pharmaceuticals, exhibits diverse pharmacological properties but excessive intake can pose health risks, necessitating reliable quantific...
A fiber-optic fluorescent biosensor based on DNAzyme-mediated multitag-regulated hybridization chain reaction for the detection of lead(II) [0.03%]
一种基于DNA酶介导的多标签调节杂化链反应的光纤荧光生物传感器用于检测铅离子
Huanxing Li,Hang Yang,Yilin Liu et al.
Huanxing Li et al.
Portable yet ultrasensitive and accurate detection of trace Pb2+ in real environmental samples remains challenging. A rapid-response evanescent wave fluorescent biosensor with a reusable sensing surface offers significant advantages for in-...
Visualizing glyphosate: A low-toxicity Zn2+-Based fluorescent probe for rapid detection from field to organism [0.03%]
可视化除草剂：一种基于低毒Zn2+的荧光探针，用于从田间到动物的快速检测
Yulong Liu,Peng Jiang,Ling Gao et al.
Yulong Liu et al.
Glyphosate, a widely used organophosphorus herbicide, poses potential threats to the environment and human health due to its residues and slow degradation. Conventional detection methods often require expensive instrumentation and complex s...
LAMP-assisted CRISPR-Cas12a platform for detection of Bacillus anthracis spores in environmental samples [0.03%]
基于CRISPR-Cas12a的LAMP平台在环境样本中检测炭疽芽孢杆菌
Borse Rushikesh Sanjay,Maria Anto Dani Nishanth,Jess Vergis et al.
Borse Rushikesh Sanjay et al.
Environmental persistence of Bacillus anthracis spores sustains anthrax transmission, necessitating rapid and field-deployable detection tools. This study aimed to develop and quantitatively evaluate a LAMP-assisted CRISPR-Cas12a assay for ...
Reduction-Alkylation Proteome Profiling (RAPP): A novel strategy for proteome-wide target identification [0.03%]
还原-烷基化蛋白质组谱分析(RAPP)：蛋白质组范围内的靶点鉴定新策略
Yiying Wu,Jingwen Yan,Yuting Chen et al.
Yiying Wu et al.
The discovery of target proteins for drugs is crucial, and mass spectrometry (MS)-based proteomics is one of the most important tools for identifying drug targets. Different target identification methodologies are suited to different applic...
Co-encapsulated urease and glucose oxidase in polyelectrolyte microcapsules for simultaneous glucose and urea determination [0.03%]
基于聚电解质微胶囊的尿素酶和葡萄糖氧化酶共固定化材料用于同时测定尿素和葡萄糖
Aleksandr L Kim,Egor V Musin,Sergey A Tikhonenko
Aleksandr L Kim
Background: Clinical monitoring of metabolic disorders requires stable tools for simultaneous analyte detection. However, conventional free-enzyme assays suffer from rapid degradation, poor operational stability, and sing...
Metal ion-modulated KRAS conformational dynamics unraveled by ultraviolet photodissociation [0.03%]
紫外光解离解析出金属离子调控的KRAS构象动力学
Zhixiong Jin,Shirui Yang,Zheyi Liu et al.
Zhixiong Jin et al.
Metal ions are indispensable cofactors governing protein conformations and biofunctions. However, given the highly dynamic and subtle nature of metal ion modulations, capturing the metal-induced conformational dynamics and resolving these s...
A robust HPLC-HILIC enrichment system for O-glycoproteomics profiling of plasma and cerebrospinal fluid across Alzheimer's disease progression [0.03%]
一种鲁棒的HPLC-HILIC富集系统，可对整个阿尔茨海默病进展过程中的血浆和脑脊液进行O-糖蛋白组学分析
Zhenpeng Deng,Yan Wang,Lei Liu et al.
Zhenpeng Deng et al.
Background: Alzheimer's disease (AD) pathogenesis involves widespread molecular alterations in both brain tissue and peripheral biofluids, yet the role of protein O-linked glycosylation in disease progression remains poor...
Acoustophoretic sample preparation integrated chemiluminescence immunoassay microsystem for automated detection of hormones in whole blood [0.03%]
声学光子集成化学发光免疫检测微系统用于全血中激素的自动化检测
Enjian Jin,Anna Go,Yonghwang Ha et al.
Enjian Jin et al.
Background: Highly sensitive and automated hormone analysis is essential for reproductive health diagnostics. Although chemiluminescence immunoassays (CLIAs) offer excellent analytical sensitivity, translating them into c...
Large Stokes shift red-emissive CDs-based ternary complexes for ratiometric/visual detection of triethylamine [0.03%]
具有大斯托克斯位移的红色发射碳点衍生物三元复合材料比率/视觉检测三乙胺
Guoliang Liu,Shaofei Wang,Zhendi Yu et al.
Guoliang Liu et al.
Background: As triethylamine (TEA) is a critical indicators for evaluating seafood freshness to ensure edible safety and human health, developing a strategy for rapid, sensitive and on-site monitoring TEA possesses an imp...