Chiral analysis by 19F NMR in PBLG-based weakly orienting media, from high-field to benchtop FT-spectrometers [0.03%]
基于PBLG的手性分析（从高场到台式FT的19F NMR弱取向介质）
Vincent Chiapolino,François-Marie Moussallieh,Philippe Lesot et al.
Vincent Chiapolino et al.
We present the first and efficient spectral resolution of enantiomeric mixtures using cryogenic free benchtop Fourier Transform (FT)-NMR instruments operating at 1.0 and 1.9 T. Measured in chiral-oriented solvents, enantiomeric discriminati...
Chiral separation of phenoxypropionic acid herbicides via capillary electrochromatography based on dummy template-chiral molecularly imprinted polymers [0.03%]
基于 Dummy 模板手性分子印迹聚合物的新型毛细管电色谱手性分离材料及其识别机制研究
Pandeng Miao,Mengmeng Yang,Junxin Zhao et al.
Pandeng Miao et al.
Background: Chiral molecularly imprinted polymers (CMIPs) represent highly promising stationary phases for capillary electrochromatography (CEC), particularly in the field of chiral separation. However, current CMIPs-CEC ...
Rethinking local spectral modelling: From per-query refitting to model libraries [0.03%]
从逐查询拟合到模型库的局部光谱建模新思考
Leonardo Ramirez-Lopez,Maxime Metz,Matthieu Lesnoff et al.
Leonardo Ramirez-Lopez et al.
Background: This work introduces liblex, a simple yet powerful algorithmic framework to streamline the use of complex spectral libraries. It converts diffuse reflectance spectroscopy (DRS) libraries into libraries of pre-...
An instrument-free height readout biosensing device based on gold nanobipyramid-loaded hydrogel for point-of-care detection of acid phosphatase and the BRCA1 gene [0.03%]
一种基于金纳米双锥体载水凝胶的无需标尺的高度读取生物传感装置，用于酸性磷酸酶和BRCA1基因的床边检测
Fangqin She,Bin Li,Na Lu
Fangqin She
Point-of-care testing (POCT) is crucial for disease diagnosis, especially in resource-limited settings with inadequate laboratory infrastructure. Although visual distance-based readout sensors present a promising approach for instrument-fre...
Integrated circuit-microfluidic biosensors for blood-based disease diagnostics-A review [0.03%]
基于血液的疾病诊断用集成电路-微流体生物传感器的研究进展综述
Sasi Kiran Boilla,Gwo-Bin Lee
Sasi Kiran Boilla
Background: Integrated circuit (IC)-integrated microfluidic biosensors have revolutionized blood-based diagnostics by merging precise electronic sensing with on-chip sample manipulation. Over the past decade, continuous p...
Bioluminescent label-free molecular switch for SARS-CoV-2 detection [0.03%]
用于检测SARS-CoV-2的生物发光无标记分子开关
Zeynab Rezaei,Hossein Keyvani,Anne K Schütz et al.
Zeynab Rezaei et al.
Background: Simple, single-step platforms for virus detection are still important for improving diagnostic testing beyond laboratory settings. Molecular switch platforms, which generate measurable signals upon specific ta...
Ultrasensitive biosensor for near femtogram-level detection of interleukin-1 beta in saliva [0.03%]
超灵敏生物传感器用于检测唾液中接近飞克级的白细胞介素-1β
Jiayi Liu,Miao Xie,Yufei Tang et al.
Jiayi Liu et al.
Periodontitis, whose early symptoms are subtle and frequently ignored, can ultimately lead to permanent harm to the teeth and their supporting tissues. Therefore, a prompt and precise diagnosis, coupled with progression monitoring, is cruci...
Reverse-engineered ratiometric sensor assisted by dual redox-active DNA intercalators for ultrasensitive and reliable detection of mercury(II) [0.03%]
基于双电子活性DNA嵌入剂的反向工程比率型传感器对汞离子的超灵敏和可靠检测
Min Chen,Xianxin Liu,Sifan Wang et al.
Min Chen et al.
Background: Traditional electrochemical DNA sensors for Hg2+ rely on target-induced conformational changes of Hg2+-binding DNA probes, which often suffer from limited signal output and complex probe design. To address the...
Modified biochar-based oxidase-like catalyst for dual-signal detection of soil alkaline phosphatase [0.03%]
改良的生物炭基类氧化酶催化剂用于土壤碱性磷酸酶的同时检测方法研究
Rongcan Cai,Zhe Zhang,Qiong Li et al.
Rongcan Cai et al.
Enzyme-like biochar has attracted considerable attention due to its simplicity and low cost. In this study, an innovative modified composite biochar, MnBBC, was synthesized by co-pyrolysis of hawthorn seeds (SZZ), bentonite, and manganese. ...
Overcoming the ''turn-off'' limitation via steric hindrance: A ''turn-on'' dual-readout nanozyme array based on spindle-shaped Prussian blue for highly selective discrimination of glutathione and food additives [0.03%]
通过空间位阻克服“关闭”限制：基于纺锤形亚铁氰化钾的“开启”双读出纳米酶阵列用于半胱氨酸和食品添加剂的高度选择性鉴别
Mei Li,Tianhui Huang,SuXuan Liao et al.
Mei Li et al.
Accurate detection and discrimination of glutathione (GSH) are critical for food safety and quality control. However, developing highly selective assays for the precise detection of GSH and its discrimination from other reducing substances ...