Mathematical model-assisted HPLC-MS/MS analysis on global, pseudo-targeted ceramide profiling and quantitation in serum [0.03%]
基于数学模型的高效液相色谱-质谱联用技术对血清中鞘氨醇类脂全局伪靶向分析及定量检测
Fei Ge,Jingai Jian,Na Li et al.
Fei Ge et al.
Ceramides (Cers) play a crucial role in sphingolipid metabolism with multiple biological activities and functions. Due to the high regularity and variability of their structures, there exist thousands of possible Cers. The structural divers...
SagMSI: A graph convolutional network framework for precise spatial segmentation in mass spectrometry imaging [0.03%]
基于图卷积网络的质谱成像精准空间分割方法研究
Mudassir Shah,Linlin Wang,Lei Guo et al.
Mudassir Shah et al.
Background: Mass Spectrometry Imaging (MSI) is a label-free imaging technique used in spatial metabolomics to explore the distribution of various metabolites within biological tissues. Spatial segmentation plays a crucial...
Ion mobility spectrometer with heated sample inlet - Solution to the issue of temperature effect on resolving power [0.03%]
一种带有加热样品入口的离子淌度谱仪——温度对分辨率影响的问题解决方案
Martin Lippmann,Moritz Hitzemann,Timo Sawatzki et al.
Martin Lippmann et al.
Background: One major challenge in detecting less volatile compounds with an ion mobility spectrometer (IMS) is preventing condensation of target molecules in the sampling line and ionization region to allow for fast resp...
Spatial distribution analysis of secondary metabolites in bolted and unbolted Saposhnikovia divaricata by atmospheric pressure laser ablation carbon fiber ionization mass spectrometry imaging [0.03%]
飞燕草离子淌渡大气压激光消解质谱成像技术分析柴胡苔与无苔挥发油物质空间分布差异研究
Na Li,Xialian Cui,Yingjie Lu et al.
Na Li et al.
Background: Bolting severely affects the medicinal value and yield of Saposhnikovia divaricata. Currently, spatial distribution of secondary metabolites in bolted and unbolted Saposhnikovia divaricata remains unknown. The...
Exponential rolling circle amplification-hybridization chain reaction (EXRCA-HCR) for AgNPs@gel-enhanced fluorescence ultrasensitive detection of miRNA-21 [0.03%]
基于银纳米颗粒@凝胶增强荧光的指数滚环扩增-杂交链式反应 ultra miRNA-21检测技术(EXRCA-HCR)
Wenjiao Zhang,Yuchen Song,Dongmei Deng et al.
Wenjiao Zhang et al.
MicroRNA (miRNA) is a common tumor marker, whose abnormal expression is often closely related to the occurrence of various diseases. However, the conventional method for detecting miRNA is qRT-PCR, requiring additional reverse transcription...
Rapid filamentous fungi gene knockout identification through high-throughput droplet microfluidics [0.03%]
基于高通量微滴流体学的丝状真菌基因敲除快速鉴别法
Yuwen Li,Jing Dai,Huan Zhang et al.
Yuwen Li et al.
Fungi are a diverse group of eukaryotic organisms, with over 1.5 million species inhabiting ecosystems worldwide. Many fungi grow as filaments (hyphae) and play critical ecological roles, both beneficial and harmful. Understanding their fun...
γ-cyclodextrin metal-organic framework-activated gold nanoclusters with water solubility as multi-enzyme mimics for simultaneous detection of pesticide and cholinesterase activity [0.03%]
γ-环糊精金属有机骨架活化金纳米团簇（溶于水），同时检测农药和胆碱酯酶活性的多酶模拟物
Bing Tan,Qian Wang,Qiaoli Liu et al.
Bing Tan et al.
Cyclodextrin metal-organic framework (CD-MOF) with environmentally friendly components has attracted enormous attention in the past few decades. However, the fragile aqueous stability has limited its application in aqueous catalysis. In thi...
A novel chemiresistive biosensor utilizing green-synthesized AgNPs and MWCNT-ZnO nanofibers for rapid detection of tuberculosis Lipoarabinomannan (LAM) antigen [0.03%]
一种利用绿色合成的AgNPs和MWCNT-ZnO纳米纤维的新型化学电阻式生物传感器，用于快速检测结核病脂阿拉伯甘聚糖（LAM）抗原
Dinesh R Rotake,Jitendra B Zalke,Shubham C Anjankar et al.
Dinesh R Rotake et al.
Background: Tuberculosis (TB) poses a major global health threat, especially in low- and middle-income countries with limited diagnostic infrastructure. Early and accurate detection is essential to control its spread and ...
A minimally instrumented method for the detection of rifampicin resistance-causing mutations in Mycobacterium tuberculosis utilizing lateral flow readout [0.03%]
一种检测结核分枝杆菌利福平耐药突变的极简型方法（采用侧向流动读取）
Ayushi Chauhan,S SivaKumar,Bhushan J Toley
Ayushi Chauhan
Background: Genotypic methods for detecting antimicrobial resistance in Mycobacterium tuberculosis (M.tb) typically require expensive instrumentation, limiting their accessibility in peripheral and resource-limited settin...
Ultrasensitive TALEs-mediated electrochemical sensor for DNA methylation detection based on RCA reaction and Exo III cyclic amplification-assisted "silver-link" crossing electrode [0.03%]
基于滚环扩增和Exo III循环放大辅助“银链接”交叉电极的超灵敏TALE介导的用于DNA甲基化检测的电化学生物传感器
Jialin Zhang,Mengyu Kang,Jinhui Li et al.
Jialin Zhang et al.
Pancreatic cancer has become one of the most challenging malignant tumors. This type of cancer shows a high mortality paralleling morbidity and a rather low 5-year survival rate. Early diagnosis of the disease is the key to prevent and trea...