Smartphone-based colorimetric sensing with reference calibration and ensemble machine learning for enhanced detection of nitrite and ammonium ions [0.03%]
基于智能手机的参考校准和集成机器学习的比色法检测亚硝酸盐和铵离子的方法
Trung Nguyen Quoc,Minh-Vuong Phan,Khoi Pham Dang et al.
Trung Nguyen Quoc et al.
Background: Rapid, low-cost detection of nutrient pollutants such as nitrite (NO2-) and ammonium (NH4+) is crucial for environmental monitoring. Conventional colorimetric instruments offer high accuracy but are expensive,...
Preparation and application of the transistor based on D-A isoindigo copolymer/GR blend for the detection of circular tumor cell [0.03%]
基于DA异靛蓝共聚物/GR掺混薄膜晶体管的循环肿瘤细胞检测研究
Caiyuan Liao,Fayu Wang,Long Fang et al.
Caiyuan Liao et al.
A field-effect transistor based on donor-acceptor (D-A) copolymer/graphene (GR) blends was successfully developed, with systematic optimizations implemented for key parameters including the concentration of polymeric monomers, selection of ...
Ultrasensitive electrochemiluminescence aptasensor for heparin-binding protein based on hybridization chain reaction (HCR) amplification and magnetic enrichment [0.03%]
基于杂交链反应(HCR)放大和磁性富集的超灵敏电化学发光适配子传感器检测肝素结合蛋白
Mengxin Cheng,Wanxin Xu,Yingying Cao et al.
Mengxin Cheng et al.
Background: Heparin-binding protein (HBP) is a multifunctional cationic protein that is rapidly released upon activation of neutrophils during infectious or inflammatory responses. It plays a crucial role in immune regula...
Surface-confined primer exchange reaction enables label-free electrochemical detection of acetamiprid in agricultural products and soils [0.03%]
基于表面限域的primer交换反应电化学传感平台用于水果和土壤中虱螨脲的无标记检测
Huimin Li,Ya Zhou,Li Yang et al.
Huimin Li et al.
Background: The widespread use of pesticides like acetamiprid has raised serious concerns about food safety and environmental pollution. Conventional techniques such as chromatography are accurate but require sophisticate...
CADEM: Species-level detection of mycobacterial cfDNA via CRISPR for pulmonary disease diagnosis [0.03%]
基于CRISPR的肺病原体分枝杆菌cfDNA种水平检测方法(CADEM)
Seungil Park,Bonhan Koo,Myoung Gyu Kim et al.
Seungil Park et al.
Background: Pulmonary infections caused by Mycobacterium tuberculosis (MTB) and nontuberculous mycobacteria (NTM) present significant clinical challenges due to overlapping symptoms and different treatments. In particular...
Specific lysine guanidination and long alkyl chain tagging-assisted negative enrichment strategy enables comprehensive profiling of protein N-terminal acetylome [0.03%]
特异赖氨酸瓜基化及长烷基链标记富集策略用于蛋白质N末端乙酰化的整体分析测定
Yang Li,Yu He,Weijie Zhang et al.
Yang Li et al.
Background: Protein N-terminal acetylation (Nt-acetylation) is a widespread and essential modification in both eukaryotes and prokaryotes. To achieve in-depth profiling of Nt-acetylome, enrichment of Nt-acetylated peptide...
Thermosensitive hydrogel-enhanced RPA-CRISPR/Cas12a biosensor for ultrasensitive detection of methylated loci in breast cancer ctDNA [0.03%]
热响应水凝胶增强的RPA-CRISPR / Cas12a生物传感器可超灵敏地检测乳腺癌ctDNA中的甲基化位点
Jianxun Hou,Yingjie Wang,Weiguang Yuan et al.
Jianxun Hou et al.
Background: Methylation differences exist between breast cancer tissues and normal tissues. The release of methylated circulating tumor DNA (ctDNA) by tumor cells provides a foundation for breast cancer liquid biopsy usin...
Novel tyrosinol-based chiral stationary phase for the separation of tetracyclic quinolines active as PXR agonists: Investigating the enantiorecognition mechanism through molecular dynamics [0.03%]
一种新颖的酪氨酚手性固定相用于四环喹啉类PXR激动剂对映异构体分离：通过分子动力学研究其对映体识别机制
Magdaléna Labíková,Bruno Cerra,Alessandro Di Michele et al.
Magdaléna Labíková et al.
Background: In recent years, a wide range of chiral molecules has been investigated as potential selectors (SOs) for enantiomeric separation in liquid chromatography, which remains a key tool in the development of new ena...
A covalent conjugation enrichment strategy for analysis of dimethyllysine sites in the proteome [0.03%]
一种用于蛋白质组中二甲基赖氨酸位点分析的共价连接富集策略
Lufeng Yan,Manqian Zheng,Mingxuan Wu
Lufeng Yan
Lysine methylation is a common protein post-translational modification, and it has three forms as monomethyllysine (Kme1), dimethyllysine (Kme2) and trimethyllysine (Kme3). All of them have exhibited significant roles in many biological pro...
Advances and clinical perspectives of boronate affinity-driven glycoproteomics: A review [0.03%]
硼酸亲和驱动糖蛋白组学研究进展及临床应用前景综述
Huiying Zhang,Yufei Shi,Fenghua Xu et al.
Huiying Zhang et al.
Background: Glycoproteomics has emerged as a powerful tool for decoding cellular communication and disease mechanisms. However, the structural complexity and low abundance of glycoproteins demand high-efficiency enrichmen...