Scheduled data-dependent acquisition MS provides enhanced identification and sensitivity in clinical lipidomics [0.03%]
基于预定的数据依赖采集质谱可增强临床脂质组学鉴定及灵敏度
Sander Johannes Thorbjørnsen Guttorm,Steven Ray Haakon Wilson,Erik Koldberg Amundsen et al.
Sander Johannes Thorbjørnsen Guttorm et al.
Background: Lipidomics can provide critical insight into metabolic changes in health and disease, but faces challenges in sensitivity, lipid coverage, and annotation accuracy. To address these limitations, we optimized a ...
Multimodal mass spectrometry - Raman imaging reveals solvent dependent structural and chemical tissue alterations [0.03%]
多模质谱-拉曼成像揭示溶剂依赖性结构和化学组织改变
Gabor Toth,Adrianna Kryska,Anna Sroka-Bartnicka et al.
Gabor Toth et al.
Background: Mass spectrometry imaging (MSI) and Raman spectroscopy imaging are two chemical imaging techniques that can reveal and visualize the chemical distributions in thin tissue sections. The two techniques are compl...
Rapid screening and annotation of the carbonyl submetabolome via bromine isotope-based derivatization sensitization assisted by structure-guided molecular network strategy [0.03%]
基于溴同位素衍生化增敏的结构导向分子网络策略快速筛选和鉴定羰基半亚胺代谢组
Dongdong Huang,Diqiang Wang,Hang Gao et al.
Dongdong Huang et al.
Background: Carbonyl compounds (CCs) are extensively present in biological and food samples with broad concentration range and high reactivity. Despite advances in chemical isotope labelling assistant liquid chromatograph...
The natural stable isotope index for de novo structural elucidation of phytomolecules with geographical and biological tracing [0.03%]
用于植物分子地理和生物追踪的从头结构阐明的天然稳定同位素指标
Xiaojing Yan,Xin Zhou,Mingyang Gong et al.
Xiaojing Yan et al.
Not like the sequencing of genome and proteome that deals with the linear combination of base-pairs or amino acids, identification of unknown natural products has been always challenging due to diverse structures and various isomers. Search...
Aminated cinnamic acid analogs as dual polarity matrices for high spatial resolution MALDI imaging mass spectrometry [0.03%]
茋胺化肉桂酸类似物作为MALDI成像质谱的双极性基质用于高空间分辨率分析
Martin Dufresne,Lukasz G Migas,Katerina V Djambazova et al.
Martin Dufresne et al.
Background: We have developed a new class of dual polarity molecules for matrix-assisted laser desorption/ionization (MALDI) imaging mass spectrometry (IMS) capable of acquiring 5 μm pixel sizes with high sensitivity tow...
VUV photoelectron ionization source for molecular beam mass spectrometer and its application for SF6 discharge product detection [0.03%]
用于分子束质谱的软电离紫外光电子离子源及其在SF6放电产物检测中的应用研究
Peng Liu,Chenxin Wu,Shan Deng et al.
Peng Liu et al.
This study developed a photoelectron ionization source (PEI) utilizing a compact vacuum ultraviolet (VUV) lamp for molecular beam mass spectrometer. Unlike conventional hot filament EI sources, the PEI source operates effectively at a press...
Construction of highly hydrophilic carbamide-linked covalent organic framework for efficient extraction of polar aromatic amines: experiments and theoretical calculations [0.03%]
高效提取极性芳香胺的高亲水性脲连接共价有机框架的构建：实验与理论计算
Qidong Yu,Xueting Cui,Wenmin Zhang et al.
Qidong Yu et al.
Background: Covalent organic frameworks (COFs) have attracted much attention in the field of sample pretreatment due to their high specific surface area, designable pore structures, and excellent stability. However, their...
Introducing a new sorbent based on hydrogen-bonded organic framework for the extraction of some pesticides from different grape juice samples [0.03%]
一种新型氢键有机框架吸附剂用于不同葡萄汁样品中一些农药提取的方法研究
Mir Ali Farajzadeh,Sanaz Barazandeh,Mohammad Reza Afshar Mogaddam
Mir Ali Farajzadeh
In this work, for the first time, a new porous material was prepared from 1,3,5-benzene tricarboxylic acid with self-assembled method and then the synthesized material was utilized as a sorbent to extract some pesticides from grape juice sa...
Near-infrared induced photothermal lateral-flow immunoassay utilizing plasmonics-active gold nanostars [0.03%]
基于等离激元活性金纳米星的近红外光热侧流免疫层析检测技术
Supriya Atta,Yuanhao Zhao,Sebastian Sanchez et al.
Supriya Atta et al.
The lateral flow immunoassay (LFIA) has become a widely accepted point-of-care diagnostic tool (POCT) due to its simplicity, portability, cost-effectiveness, and rapid biomarker detection capabilities. However, its sensitivity in detecting ...
A proof of concept study on the use of online two-dimensional SEC-UV-RPLC-MS method for the multi-attribute characterization of gene therapy products [0.03%]
一种在线二维SEC-UV-RPLC-MS方法用于基因治疗产品多属性表征的验证研究
Megane K Aebischer,Serge Rudaz,Davy Guillarme
Megane K Aebischer
Background: Recombinant adeno-associated virus (rAAV) vectors have emerged as a leading platform for gene therapy, supported by several FDA-approved products and numerous clinical trials. Due to their biological complexit...