Mussel-inspired molecular strategy for ultrasensitive detection of multiple chiral molecules [0.03%]
受贻贝启发的分子策略用于超灵敏检测多种手性分子
Yanhong Liu,Yang Li,Chengcheng Suo et al.
Yanhong Liu et al.
Chiral recognition in racemic mixtures remains a critical challenge in life and environmental sciences, while the practical development of chiral electrochemical sensors is often restricted by complicated fabrication processes and insuffici...
Visualization of hepatic fibrosis and assessment of therapeutic effect by an asymmetric BODIPY fluorescent probe capable of dually detecting lipid droplets and nitric oxide [0.03%]
一种能够同时检测脂滴和一氧化氮的不对称BODIPY荧光探针可视化肝纤维化并评估治疗效果
Yue Wu,Lanqing Li,Lei Chen et al.
Yue Wu et al.
Hepatic fibrosis represents a critical stage in the progression of chronic liver disease. Nitric oxide (NO) and lipid droplets (LDs), as important biomarkers, are closely associated with the pathogenesis of hepatic fibrosis. Effective track...
A SERS-active swab for integrated sampling, response and detection of saliva of normal and sleep-deprived mice [0.03%]
一种用于小鼠唾液采样、响应和检测的SERS活性拭子
Xingyu Wu,Yuchuan Wang,Jinfeng Lin et al.
Xingyu Wu et al.
Background: The redox status is closely related to physiology and pathology of organisms. Saliva has received increasing attention in health monitoring and medical diagnosis and more importantly, saliva is an ideal sample...
Cross-study validation and guidance for resampling approaches for partial least squares discriminant analysis in spectral machine learning [0.03%]
谱系机器学习中用于偏最小二乘判别分析的重抽样方法的跨研究验证与指导方针
Aidan P Holman,Dmitry Kurouski
Aidan P Holman
Resampling strategies are central to model selection and performance estimation in spectroscopic machine learning (SML), yet their impact is often treated as secondary to model choice. In this tutorial study, we systematically evaluated how...
Neutral molecular networks: Polarity-independent tool for mass spectrometry data [0.03%]
中性分子网络：一种极性无关的质谱数据工具
Nicola Dalla Valle,Pietro Franceschi,Mar Garcia-Aloy et al.
Nicola Dalla Valle et al.
Untargeted mass spectrometry-based metabolomics generates large-scale fragmentation data, typically analyzed separately in positive and negative ionization modes. The fragmentation patterns of the same molecule usually capture distinct but ...
A pH-regulated single-material fluorescence sensor array with tunable response patterns for discrimination and quantification of Hg(II), Cr(VI), and Mn(VII) [0.03%]
一种可调节响应模式的单材料pH控制型荧光传感器阵列用于Hg(II)、Cr(VI)和Mn(VII)的识别及定量研究
Zhenhua Yang,Jiamin Zhou,Pan Du et al.
Zhenhua Yang et al.
A pH-regulated analytical strategy was developed for the discrimination and concentration-dependent analysis of metal ions using a single-material fluorescence sensor array based on nitrogen and sulfur co-doped carbon dots (NS-CDs). The NS-...
An amplification-free CRISPR/Cas12a-nanopipette electrochemical sensor for in situ discrimination of Salmo salar and Oncorhynchus mykiss [0.03%]
一种扩增free的CRISPR/Cas12a-纳米pipette电化学传感器用于三文鱼和虹鳟的就地鉴别分析
Yangyang Geng,Fang Zhao,Jia Yang et al.
Yangyang Geng et al.
Background: Salmo salar (S. salar) and Oncorhynchus mykiss (O. mykiss) exhibit highly similar morphological characteristics, which frequently leads to market adulteration. This phenotypic resemblance poses significant cha...
Rational design of a o-phosphoethanolamine-functionalized sheet-like nanozyme enables target-induced crosslinking for sensing Cr3 [0.03%]
合理设计出一种焦磷酸乙醇胺功能化的片状纳米酶可实现目标诱导交联用于Cr³⁺检测
Xingen Tang,Linjie Wang,Zhijian Bu et al.
Xingen Tang et al.
Background: Trivalent chromium (Cr3+), a relatively environmentally benign and biologically beneficial species of chromium, is widely applied in manufacturing processes as well as in the food and healthcare industries. Ex...
Programmable Fc-encoded DNA tile-cube capture enables a thrombin-activated ratiometric ECL/SERS biosensor via a PAM-engineered toehold switch and CRISPR/Cas12a cleavage [0.03%]
可通过PAM工程toehold开关和CRISPR / Cas12a切割激活的凝血酶比率ECL / SERS生物传感器的可编程Fc编码DNA四面体捕获
Jing Qian,Jingfen Lu,Xu Chen et al.
Jing Qian et al.
Background: Accurate thrombin detection is important for coagulation-related assessment, but reliable quantification at ultralow levels remains challenging because matrix interference, electrode-to-electrode variation, an...
Smartphone-based fluorescence imaging combined with a convolutional neural network-assisted intelligent multichannel immunosensor for simultaneous identification of four Salmonella serotypes based on multicolor luminescent iridium complexes [0.03%]
基于多色铱配合物的智能手机荧光成像结合卷积神经网络智能多通道免疫传感器同时识别四种沙门氏菌血清型
Libing Ke,Xue Liu,Mingkai Gu et al.
Libing Ke et al.
Background: Salmonella Typhi, Salmonella Paratyphi A, Salmonella Paratyphi B, and Salmonella Paratyphi C are known to cause enteric fever and often present similar clinical symptoms, which may lead to misdiagnosis and pos...