Low-background and label-free loop-mediated isothermal amplification for rapid detection of foodborne pathogens using amplicon-templated copper nanoclusters [0.03%]
适配体铜纳米团簇比色读出的低本底环介扩增快速检测食源性病原菌
Wenyu Du,Shuanglong Wang,Yining Luo et al.
Wenyu Du et al.
Background: Loop-mediated isothermal amplification (LAMP) is a simple, low-cost, and instrument-free assay, which is highly adaptable for the detection of foodborne pathogens. However, current methods have a high backgrou...
A homogeneous mass-encoded strategy for mass spectrometric biosensing of multiplex proteins [0.03%]
基于同质质量编码的多重蛋白质谱检测新策略研究
Junjie Hu,Fei Liu,Yunlong Chen et al.
Junjie Hu et al.
Background: Protein kinases play important roles in fundamental biological processes. Aberrant activities may result in many diseases, thus the detection of multiplex kinase activities is important in clinical diagnosis. ...
A versatile two-dimensional liquid chromatography coupled to high-resolution mass spectrometry platform for unraveling chromatographic profiles of large synthetic oligonucleotides [0.03%]
一种通用的二维液相色谱与高分辨率质谱联用平台用于解析大分子合成寡核苷酸的色谱图谱
Bifan Chen,Bingchuan Wei,Lulu Dai et al.
Bifan Chen et al.
Background: Many gene expression-modulating therapeutics, as well as clustered regularly interspaced short palindromic repeats (CRISPR)-Cas9 gene editing technology have greatly transformed the field of biomedical researc...
Method development and validation for analysis of 74 per- and polyfluoroalkyl substances (PFAS) in food of animal origin using QuEChERSER method and LC-MS/MS [0.03%]
基于QuEChERS方法和LC-MS/MS的动物源性食品中74种全氟及多氟化合物（PFAS）检测方法建立及验证
Kevin M Stroski,Yelena Sapozhnikova
Kevin M Stroski
Background: The detection of per- and polyfluoroalkyl substances (PFAS) in food is extremely important for ensuring safe food consumption however most analytical methods focus on only a small group of known analytes. The ...
Development of a quantitative structure-response relationships to estimate concentrations of plasticizer metabolites in urine without reference standards using non-targeted analysis with liquid chromatography high-resolution mass spectrometry [0.03%]
开发定量结构-反应关系以估计塑料增塑剂代谢物在尿液中的浓度（无需参考标准），使用非目标分析与液相色谱高分辨率质谱法
Yong-Lai Feng,Jerrie Feng,Anca Baesu et al.
Yong-Lai Feng et al.
Background: Plasticizers are characterized as endocrine disruptors, and human exposure to these chemicals can adversely affect the reproductive system. Non-targeted analysis (NTA) using liquid chromatography - high resolu...
Luxuriant Foliage: High-Sensitivity detection of saxitoxin using an enzyme-assisted double-cycling amplification SERS aptamer sensor [0.03%]
繁茂的树叶——使用酶辅助双循环放大SERS适配子传感器高灵敏度检测石房蛤毒素
Xiaofan Liu,Xinna Bai,Ziyang Song et al.
Xiaofan Liu et al.
Background: Saxitoxin (STX), one of the most toxic marine toxins known, poses severe risks to marine ecosystems and human health through contaminated seafood. Effective monitoring of STX is critical for early red tide war...
Controllable synthesis of chiral hierarchical porous Co(OH)2 and its application in rapid chiral recognition and separation [0.03%]
手性分层级氢氧化钴的合成及其在快速手性识别和拆分中的应用研究
Jinhua Xu,Jinyu Zhang,Wenmin Zhang et al.
Jinhua Xu et al.
Background: Chiral pollutants present significant environmental and health concerns, with neurotoxic amino acid analogs like β-N-methylamino-L-alanine (BMAA) demonstrating enantiomer-specific bioaccumulation in aquatic e...
Adsorption of fluoroquinolones on hollow Co3S4 polyhedron sulfidated from ZIF-67 and its application of dispersed solid phase extraction prior to HPLC-UV [0.03%]
基于ZIF-67空心Co3S4十二面体的磺酸氟喹诺酮吸附及固相萃取分散应用及其HPLC-UV检测方法
Youfang Qi,Xueping Dang,Huaixia Chen
Youfang Qi
Background: Developing pretreatment technique with new adsorbent is essential to improve the detection sensitivity of trace fluoroquinolones (FQs) in complex sample. Zeolite imidazole skeleton-67 (ZIF-67) has adsorbabilit...
Gold nanoparticle-assisted, label-free SELEX coupled with high-throughput NGS for generating highly sensitive and specific DNA aptamers targeting Aflatoxin B1 [0.03%]
基于金纳米颗粒的无标记SELEX结合高通量NGS技术获得高效灵敏的黄曲霉毒素B1特异性DNA适配体分子
Shazia Shareef,P Hariprasad
Shazia Shareef
Background: Aflatoxin B1 (AFB1) is a highly toxic fungal secondary metabolite that poses serious health risks to humans and animals, prompting the development of sensitive and specific detection technologies. Aptamer-base...
Biological sample desalting and buffer replacement based on electromigration in a discontinuous electrolyte system using a 3D printed device [0.03%]
基于不连续电解质体系中电迁移效应的生物样品脱盐及缓冲液置换研究
Vanda Kocianová,Ivona Voráčová,Yann Astier et al.
Vanda Kocianová et al.
Background: The quality and yield of DNA specimens are essential for downstream analyses. Complex biological or environmental samples contain interfering compounds requiring advanced protocols for removing salts, small or...