A deprotection-oxidation cascade-regulated dual-responsive near-infrared fluorescent probe for individual and sequential detection of H2S/HClO with applications in food safety monitoring [0.03%]
一种用于食品安检测的个体及连续检测H₂S/HClO的脱保护-氧化级联调控型双刺激响应性近红外荧光探针
Jie Yang,Chao Fu,Yicong Zhou et al.
Jie Yang et al.
Background: Hydrogen sulfide (H2S) and hypochlorous acid (HClO), as critical reactive sulfur (RSS) and oxygen (ROS) species, respectively play dual roles in physiological regulation and food safety. While numerous fluores...
SERS fingerprinting of β2-agonists for anti-doping based on Au-COF substrate [0.03%]
基于Au-COF基底的β2受体激动剂赛博禁用化合物表面增强拉曼光谱指纹识别技术
Siqing Liu,Liping Chen,Xingju Li et al.
Siqing Liu et al.
Background: β2-agonists, also known as β2-adrenoceptor agonists, are secreted by the adrenal medulla of the animal body and have a characteristic catecholamine structure. When inhaled, the drug rapidly relaxes the smoot...
Understanding sub-cellular mechanochemical correlations of the neonatal extrahepatic bile duct extracellular matrix by atomic force microscope-Infrared spectroscopy [0.03%]
原子力显微镜-红外光谱法研究胆管细胞外基质的亚细胞机械化学关联性
Huiyong Li,Kapish Gupta,Zhenqin Wang et al.
Huiyong Li et al.
Background: The neonatal extrahepatic bile duct (EHBD) is highly susceptible to injury and fibrotic remodeling, yet the sub-cellular mechanochemical basis of this vulnerability remains poorly understood. Atomic force micr...
Label-free electrochemical levodopa detection via dummy imprinted polymers for advanced disease monitoring [0.03%]
基于 Dummy 模板分子印迹聚合物的左旋多巴无标记电化学检测用于高级疾病监测
O Jamieson,A Dann,X Liu et al.
O Jamieson et al.
Current estimates see 25.2 million people living with from Parkinson's disease (PD) worldwide by 2050, with no cure close to being available. With therapeutic LDp (LDp) use being the mainstay treatment for a vast proportion of individuals w...
Unlocking the complexity of macromolecular protein heterogeneity of glycoprotein IgE via an optimized online digestion middle-down proteomics approach [0.03%]
通过优化的在线消化中间向下蛋白质组学方法解锁糖蛋白IgE宏分子蛋白异质性的复杂性
Ruijie Liu,Zixin Liang,Shujun Xia et al.
Ruijie Liu et al.
Background: Proteoform-level analysis of large, highly modified proteins (≥50 kDa) such as immunoglobulin E (IgE) remains challenging due to their size and molecular heterogeneity. While traditional bottom-up proteomics ...
Novel diffusion gradient in thin-films based on antibiofouling Ag/polydopamine membranes for measurement of antibiotics in natural waters [0.03%]
基于抗菌防污的聚多巴胺/银纳米膜的新型扩散层在薄膜中的应用及其测定天然水中抗生素的新方法研究
Jiaxing Xie,Fan Ge,Xinyi Yan et al.
Jiaxing Xie et al.
Background: The diffusion gradient in thin-films (DGT) device is widely used for in situ measurement of pollutants in aquatic environments, offering high enrichment efficiency and robustness to environmental variations su...
RNA sample preparation strategies for mass spectrometry sequencing of the epitranscriptome and therapeutic RNAs: A review [0.03%]
用于表转录组和治疗性RNA的质谱测序的RNA样品制备策略：综述
Nina J Fitzgerald,Weichen Huang,Kevin D Clark
Nina J Fitzgerald
Background: More than 170 post-transcriptional modifications of RNA have been discovered to date that are increasingly recognized as key contributors to all aspects of RNA function, including RNA metabolism, trafficking, ...
DPPH Rf-shift assay to overcome spectral interference: A rapid, portable TLC-based approach for semi-quantitative antioxidant evaluation [0.03%]
一种克服光谱干扰的DPPH Rf偏移法：一种快速、便携式的薄层色谱半定量抗氧化评价方法
Garima Singh,Perinkulam Ravi Deepa,Prabhat Nath Jha
Garima Singh
Accurate assessment of antioxidant activity is essential for evaluating compounds in food, pharmaceutical, and biomedical research. Conventional methods, such as the DPPH spectrophotometric assay, are widely used due to their simplicity but...
Renato L Gil,Samuel Silva,Marília Barreiros Dos Santos et al.
Renato L Gil et al.
Nitrite is a key water quality indicator whose monitoring is essential for environmental and human safety protection, yet conventional methods such as chromatography and spectrophotometry require expensive instrumentation and centralised la...
A protease-resistant and anti-fouling electrochemical biosensing interface constructed with dl-serine modified Y-shaped peptides for reliable analysis of aminopeptidase N in human serum [0.03%]
一种基于dl-丝氨酸修饰Y形多肽构建的抗蛋白酶降解和防污染电化学生物传感界面用于人血清中氨基肽酶N检测
Yudong Wang,Yanxin Li,Yinan Zhan et al.
Yudong Wang et al.
Electrochemical sensing techniques are still facing the challenges of biofouling and insufficient probe stability in complex biological matrices. To address this issue, we have designed a dl-serine Y-shaped peptide (YPEP) integrating the an...