SPARC: A programmable molecular diagnostic platform based on a signal-triggered, self-supplied crRNA and tiered PER-transcription-CRISPR cascade for early detection of hepatocellular carcinoma [0.03%]
基于信号触发的自供体crRNA和分层PER-转录-CRISPR级联反应的可编程分子诊断平台SPARC用于早期检测肝细胞癌
Xinying Chang,Cong Han,Haishuo Ji et al.
Xinying Chang et al.
Background: Accurate quantification of microRNAs (miRNAs) is essential for early cancer detection, yet remains challenging due to their short length, low abundance, and high sequence similarity. Existing assays often stru...
Development and validation of a method for determinion of organophosphorus flame retardant di-ester and hydroxylated metabolites in human urine [0.03%]
人尿中有机磷阻燃剂双酯及其羟基代谢物的测定与验证方法的发展及验证
Xiaohong Yu,Tian Qiu,Jingyu Wang et al.
Xiaohong Yu et al.
Background: As biomarkers for assessing human exposure to organophosphate flame retardants (OPFRs), the accurate measurement of urinary metabolites of OPFRs (mOPFRs) is critical for evaluating their health impacts. ...
Colorimetric aptasensor based on GO-SELEX screened aptamers for detecting norfloxacin antibiotic residues in fish and shrimp [0.03%]
一种新型比色适配子传感器：用于检测鱼和虾中诺氟沙星抗生素残留物的GO-SELEX筛选获得的aptamer基传感器
Xue Wang,Zhaoyang Zhou,Shuang Jiang et al.
Xue Wang et al.
Norfloxacin (NOR) has been widely applied in animal husbandry and aquaculture because of its potent antibacterial activity, broad-spectrum efficacy and cost-efficient. Nevertheless, its inappropriate use may result in teratogenic and carcin...
Preparation of ZIF-8 grafted magnetic solid-phase extraction sorbent for sensitive determination of four cannabinoids in urine and oral fluid [0.03%]
制备ZIF-8接枝磁固相萃取吸附剂以用于尿液和唾液中四种大麻素的高灵敏测定
Hongyu Ning,Yilei Fan,Haodong Wang et al.
Hongyu Ning et al.
Background: The global increase in cannabis use has created a strong demand for reliable and efficient detection methods. Traditional urine-based assays are widely used and standardized, but suffer from complex hydrolysis...
Point-of-need and portable sensing strategies for quality and safety assessment of Traditional Chinese Medicine products: A critical analytical review [0.03%]
用于评估中药产品质量和安全的现场及便携式传感策略批判性分析评论
Zihua Wang,Beibei Liu,Altaf Hussain et al.
Zihua Wang et al.
Sensor technology has emerged as a transformative tool for point-of-need and portable quality control and safety assessment of Traditional Chinese Medicine (TCM) products. Although separation and detection technologies have improved, there ...
A multi-functional effervescent tablet for one-pot effervescent/derivatization/extraction: An integrated strategy for sulfonamide residue analysis [0.03%]
一种多功能的泡腾片用于一锅泡腾/衍生/萃取：一种磺胺类残留物分析的整体策略
Di Chen,Yixin Ma,Xirui Pei et al.
Di Chen et al.
Background: Sulfonamides are extensively used antimicrobials, but residues in food raise health risks such as allergies, antimicrobial resistance, and carcinogenicity. Strict residue limits require sensitive and efficient...
Exploring lactoferrin as an innovative covalently immobilized chiral selector for the selective separation of pharmaceutical enantiomers using HPLC [0.03%]
乳铁蛋白作为创新型共价固定手性选择剂用于HPLC拆分药物对映异构体的研究
Adel Ehab Ibrahim,Samy G Alamir,Ghanem Al-Thani et al.
Adel Ehab Ibrahim et al.
Background: Molecular chirality has a profound impact on pharmaceutical drugs' efficacy and safety. Thus, chiral recognition plays a vital role in drug development throughout all process stages. LF is a globular glycoprot...
Combining laser-induced breakdown spectroscopy (LIBS) and time-gated Raman spectroscopy for underwater ores identification [0.03%]
结合激光诱导击穿光谱（LIBS）和时间门控拉曼光谱进行水下矿石识别
Jiaojian Song,Ye Tian,Yuanyuan Xue et al.
Jiaojian Song et al.
Background: As the land-based mineral deposits are depleting fast, deep-sea metal mineral resources have been proven to have a great mining value. Traditional deep-sea mineral detection techniques require ore samples to b...
Classification of DNA secondary structures by combining multiple spectral techniques with machine learning [0.03%]
基于机器学习和多种光谱技术组合的DNA二级结构分类
Hong Luo,Guantong Xu,Yujing Zhang et al.
Hong Luo et al.
Background: The identification of structural features is an essential prerequisite for the determination of DNA secondary structures and investigating structural formation mechanisms. Circular dichroism (CD) spectroscopy,...
·ATP-enhanced PB@MIL-100(Fe) nanozyme enables dual-mode ratiometric colorimetric and smartphone-based hydrogel detection of nitrite in food samples [0.03%]
· ATP增强的PB@MIL-100（Fe）纳米酶可在食品样品中实现双模式比率比色法和基于智能手机的水凝胶测定亚硝酸盐
Biyao Dai,Quanyong Dong,Taiqi Hao et al.
Biyao Dai et al.
Background: Nitrite residues pose significant threats to food safety, as excessive consumption of this may cause serious health risks to human. Conventional techniques such as Griess reagent and chromatographic methods ca...