Explainable deep learning combined with SERS for simultaneous detection of nicotine and etomidate isomers in E-cigarettes [0.03%]
结合SERS的可解释深度学习同时检测电子烟中的尼古丁和依托咪酯异构体
Yazhou Qin,Xuqing Wang,Mengze Fu et al.
Yazhou Qin et al.
The incorporation of illegal drugs into e-cigarettes poses significant threats to both human health and societal safety. Therefore, the development of accurate and rapid detection methods for illicit drug additives in e-cigarettes is of sig...
An aptamer-mediated EXPAR fluorescence biosensor for early and sensitive detection of Aβ42 and Aβ40 [0.03%]
一种适配体介导的用于早期灵敏检测Aβ42和Aβ40的EXPAR荧光生物传感器
Haoyu Wu,Chengsen Chai,Md Saimul Islam et al.
Haoyu Wu et al.
Background: Alzheimer's disease (AD) is a common neurodegenerative disorder with increasing cases worldwide. Early screening is important for AD prevention and treatment, but current methods still face many challenges. ...
Breaking the sensitivity barrier in ELISA: A molecularly engineered peptide nanointerface achieves ultrasensitive detection of zearalenone [0.03%]
突破酶联免疫吸附试验的灵敏度壁垒：一种分子工程肽纳米界面实现玉米赤霉烯酮的超灵敏检测
Zijun Yang,Zhiwei Liu,Zhongqi Lin et al.
Zijun Yang et al.
Background: Biosensing performance is often compromised by antibody activity loss caused by random immobilization, which remains a critical challenge in immunoassay development. Conventional trial-and-error strategies for...
Mitochondria-targeted redox-logic carbon dots for in vivo realtime visualization of peroxynitrite during wound-healing [0.03%]
线粒体靶向红氧逻辑碳点在伤口愈合过程中的过氧亚硝酸根成像研究
Jing-Yu Hu,Xin Gen,Yuan-Qiang Sun et al.
Jing-Yu Hu et al.
Mitochondrial oxidative imbalance is closely associated with inflammation, tissue injury and disease progression, where endogenous thiols and peroxynitrite (ONOO-) play a competitive dominant role in determining cellular redox status. Howev...
Harnessing vinylferrocene microgel-based photonic interferometers for clinical X-ray sensing [0.03%]
基于乙烯基铁苯并稠合微凝胶光子干涉仪的临床X射线传感检测
Jinnan Liu,Yajie Wang,Rui Hu et al.
Jinnan Liu et al.
Background: X-rays play an essential role in modern tumor radiotherapy. Precise X-ray dosimetry is crucial for tumor radiotherapy to maximize therapeutic efficacy while minimizing normal tissue damage. Compared to traditi...
Sensitivity-improved nanozyme LFIA with optimized fluid control on centrifugal microfluidic platform [0.03%]
基于离心微流控平台的灵敏度增强型纳米酶LFIA及其优化流动控制方法研究
Lei Wang,Jiaxi Zhou,Hao Chen et al.
Lei Wang et al.
Due to the inflexible manual operation, the sensitivity of the nanozyme-based lateral flow immunoassay (LFIA) can be potentially limited by incontrollable chromatography, insufficient utilization of sample or reagent, and suboptimal binding...
Cascade catalysis-based signal amplification for colorimetric detection of β-galactosidase activity and its application [0.03%]
基于级联催化信号放大的比色检测β-半乳糖苷酶活性及应用研究
Lu Cheng,Yong Zhao,Zaiwei Wen et al.
Lu Cheng et al.
Background: β-Galactosidase (β-Gal) serves as an important biomarker for primary ovarian cancer and cellular senescence, as well as a key indicator for Escherichia coli (E. coli). Besides, β-Gal serves as a common repo...
Simulated construction of tilmicosin nucleic acid aptamers based on molecular docking and molecular dynamics techniques [0.03%]
基于分子对接和分子动力学技术的泰拉霉素核酸适配体的模拟筛选与构建
Hongyu Zhang,Huaqing Sun,Xiying Mao et al.
Hongyu Zhang et al.
Background: Traditional aptamer screening methods often prove ineffective for small molecule targets, primarily due to the inherent structural limitations of such compounds. Their simple architecture, limited functional g...
Elimination of carryover contamination for DNA methylation analysis based on isothermal amplification and lateral flow assay [0.03%]
基于等温扩增和侧向流动分析的DNA甲基化检测的交叉污染消除方法
Xiaonan Liu,Jiaxing Zhang,Wenjing Hu et al.
Xiaonan Liu et al.
Background: Aberrant DNA methylation is a significant prognostic of tumorigenesis, making it a promising biomarker for early diagnosis of cancer. Although bisulfite conversion combined with nucleic acid amplification can ...
High-strength microneedle sensor for sensitive lactic acid and pH detection [0.03%]
高强度微针传感器用于灵敏检测乳酸和PH值
Zhaoxin Li,Dingyi Zhang,Shengtian Sang et al.
Zhaoxin Li et al.
Background: In the new intelligent medical system, miniaturized wearable biological detection sensors are crucial for real-time monitoring of human health, especially when combined with flexible microneedle arrays that ca...