Enhanced ELISA detection by target protein enrichment with MIP: A new strategy for ultra-sensitive protein detection [0.03%]
基于MIP目标蛋白富集的ELISA检测新策略用于超灵敏蛋白质检测
Yafei Wang,Haitao Wang,Yan Zhang et al.
Yafei Wang et al.
Background: Ultra-sensitive detection of biomarkers is critical for disease diagnosis and other applications. Immunoassays, particularly enzyme-linked immunosorbent assay (ELISA), are commonly used for protein biomarker d...
Overcoming limitations in exhaled breath aerosol analysis - Untargeted breathomics for the identification of endogenous breath biomarkers using LC-HRMS/MS [0.03%]
克服呼出气溶胶分析的局限性——使用LC-HRMS/MS进行非靶向呼吸组学以识别内源性呼吸生物标志物
Juel Maalouli Schaar,Selina Hemmer,Sascha K Manier et al.
Juel Maalouli Schaar et al.
Background: Human exhaled breath (EB) aerosol is a suitable matrix for the non-invasive bioanalysis of both volatile but also non-volatile compounds. One of the key challenges in drug monitoring studies is the lack of sta...
Portable microfluidic-LAMP assay for rapid on-site detection of eight highly pathogenic viruses [0.03%]
便携式微流控-LAMP检测八种高致病性病毒现场快速诊断系统
Huan Li,You Nie,Yi Wu et al.
Huan Li et al.
Background: The recent global spread of highly pathogenic viruses, such as Mpox and Ebola viruses, highlights the urgent need for multiplex detection technologies. Current methods lack the capability for simultaneous iden...
Analytical quality control in targeted lipidomics: Evaluating the performance of commercial plasma as a surrogate for pooled study samples [0.03%]
靶向脂质组学中的分析质量控制：评估商业血浆作为汇总研究样本替代品的性能
Alanah Grant-St James,Aude-Claire Lee,Alex J Lee et al.
Alanah Grant-St James et al.
Background: Pooled quality control (PQC) samples are the gold standard for data quality monitoring in metabolic phenotyping studies. Typically composed of equal parts from all study samples, PQCs can be challenging to gen...
Precise detection of the low-quality cooking oil by monodisperse droplet generation in a flow-focusing microdroplet generator [0.03%]
基于流动聚焦的单分散微液滴发生器精准检测地沟油
Wen Zeng,Bohang Wang,Honglong Chang et al.
Wen Zeng et al.
Background: To precisely and efficiently detect the low-quality cooking oil is of great importance to guarantee the food safety in our daily life. Due to the complexity of its origin, the convenient and effective detectio...
SERS hydrogel designed using a microfluidic droplet platform for label-free therapeutic drug monitoring of doxorubicin in human serum [0.03%]
基于微流控液滴平台设计的SERS水凝胶用于人类血清中多柔比星的无标记药物监测
Ying Wang,Jinru Cao,Ziwei Xu et al.
Ying Wang et al.
Background: Doxorubicin (DOX) is an anthracycline anticancer drug that is commonly employed in the treatment of acute leukemia, malignant lymphoma, breast cancer and prostate cancer. Given the narrow safe dosage range and...
A novel Zn2+ probe for fluorescent monitoring of drug and E6/E7 protein interaction in living cells [0.03%]
一种新型的Zn2+探针用于检测药物与E6/E7蛋白在活细胞中的相互作用
Zhenzhen Xie,Lan Yu,Zuoping Li et al.
Zhenzhen Xie et al.
Background: The zinc-binding sites within the human papillomavirus (HPV) E6/E7 oncoproteins play a critical role in maintaining structural stability and represent promising therapeutic targets due to their cysteine-mediat...
Polymeric photonic crystal platform for organic amines detection based on enzyme inhibition [0.03%]
基于酶抑制的聚合物光子晶体有机胺检测平台
Lu Li,Saibo Liang,Juan Wei et al.
Lu Li et al.
Background: The extensive use of organic amines in industries has led to significant environmental concerns. Traditional detection methods, such as chromatography, are highly accurate but costly, time-consuming, and requi...
Sensitive detection of boron-containing drug delanzomib by a luminescence probe in health-related samples [0.03%]
一种用于健康相关样本中含硼药物Delanzomib灵敏检测的发光探针
Shaozhen Jing,Xiaolei Wu,Xueliang Wang et al.
Shaozhen Jing et al.
Background: Boron-containing drugs are widely used in anti-inflammatory, anti-bacterial, anti-tumor and other applications, thus it is important to develop methods for their detection. However, the sensitive detection of ...
AuNPs@UiO-66-(COOH)2-NH2/Eu for ratiometric fluorescent and colorimetric sensing of trace inorganic mercury in water samples [0.03%]
用于水样中痕量无机汞比率型荧光和比色检测的AuNPs@UiO-66-(COOH)2-NH2-Eu
Zifei Wu,Hao Ding,Kailai Xu et al.
Zifei Wu et al.
Background: due to the toxicity and widespread distribution of inorganic mercury ions (Hg2+), it is a crucial task for researchers to develop simple methods for field analysis of water samples for trace Hg2+. ...