Noncovalent radiolabeling of microplastics using a desferrioxamine-conjugated Nile Red derivative for quantitative in vivo tracking [0.03%]
利用偶联去铁敏的尼罗红衍生物对微塑料进行非共价放射性标记用于定量活体示踪
Jung Eun Park,Jun Young Lee,Jeong Hoon Park et al.
Jung Eun Park et al.
Background: Microplastics are now recognized as environmental contaminants with growing concerns regarding their potential impact on ecosystems and human health. Understanding their in vivo fate is essential for accurate ...
Aptamer-based sensing array coupled with multiple pattern recognition algorithms for accurate β-lactoglobulin discrimination in complex matrices [0.03%]
基于适配体的传感器阵列结合多种模式识别算法用于复杂基质中β-乳球蛋白的准确鉴别
YiChun Zhang,Hongwei Qin,Xibao Gao et al.
YiChun Zhang et al.
Background: The β-Lactoglobulin (β-LG), a major milk allergen, contributes to rising health concerns, especially in infants and children. Although rapid detection methods have been reported, the complex matrix effects i...
Unlocking potent oxidase-like activity in bimetallic MnCo-MOFs: A nanozyme-based immunoassay for rapid detection of a Lumpy skin disease virus protein [0.03%]
基于纳米酶的免疫分析法利用双金属MnCo-MOFs检测牛结节性皮肤病病毒蛋白质
Mingzhu Wang,Yuanjie Deng,Zixiang Zhu et al.
Mingzhu Wang et al.
Background: The escalating economic threat of Lumpy skin disease (LSD) demands rapid, point-of-care diagnostic tools that overcome the limitations of conventional methods. Current nanozyme-based assays are often limited b...
A flexible antenna immunosensor with AuPt-graphene film for wireless detection of tetanus toxin [0.03%]
一种带有AuPt-石墨烯膜的柔性天线免疫传感器用于无线检测破伤风毒素
Mengya Tian,Xiuwei Xuan,Cheng Liu et al.
Mengya Tian et al.
Backgroud: The danger of tetanus originates from the tetanus toxin (TT) produced by Clostridium tetani. This toxin primarily attacks the central nervous system, leading to severe multi-system damage and even posing a thre...
Visualization of endogenous hypochlorous acid during ferroptosis based on Rhodamine B fluorescent probe [0.03%]
基于罗丹明B荧光探针的铁死亡过程中内源性次氯酸可视化研究
Shida Ma,Shujie Zhang,Feifei Jiang et al.
Shida Ma et al.
Hypochlorous acid (HClO) plays critical roles in ferroptosis process and the specific molecular mechanism related to it is still obscure. To reveal HClO fluctuation in the ferroptosis cells, a fluorescence turn-on probe RDM-577 that can det...
PVA modification mitigates PVDF hydrophobicity for concurrent protein and glycan analysis [0.03%]
PVA修饰可缓解PVDF的疏水性，以同时分析蛋白质和聚糖
Gang Liu,Yuqing Li,Yating Wang et al.
Gang Liu et al.
Glycosylation is a critical post-translational modification of proteins that plays essential roles in diverse biological and pathological processes. However, conventional glycan analysis methods (e.g., hydrazinolysis, PNGase F digestion) su...
DMSN@AuNPs-enhanced QCM immunosensor array for non-invasive and highly sensitive detection of Cyfra21-1 in saliva [0.03%]
基于DMSN@AuNPs增强型QCM免疫传感器阵列的非侵入式唾液中细胞角蛋白19（Cyfra21-1）高灵敏检测法
Xiaojing Zhang,Hongyang Guo,Li Sin Wong et al.
Xiaojing Zhang et al.
Early detection of oral cancer is essential for improving clinical outcomes, and salivary biomarkers offer a non-invasive approach for early screening. Cyfra21-1, a cytokeratin fragment detectable in saliva, is a clinically relevant biomark...
Automated sample-preparation and mass spectrometry-based assays for free and total Infliximab: Enabling therapeutic drug monitoring of monoclonal antibodies [0.03%]
用于检测英夫利昔单抗总抗体和药物自身水平的自动化样品处理和质谱测定法：使针对单克隆抗体的治疗药物监测成为可能
Melissa J Sam,David G Harman,Catherine M Toong et al.
Melissa J Sam et al.
Background: Therapeutic drug monitoring (TDM) of biologics is commonly used in the management of inflammatory disease. However, current clinical tests are confounded by the interaction of drug and anti-drug antibodies (AD...
Old advice on multivariate calibration: still in force, but not always followed. A tutorial [0.03%]
多变量校正的旧建议：仍然有效但并不总是被遵循。教学文章
Alejandro C Olivieri
Alejandro C Olivieri
Background: A growing number of multivariate calibration protocols use deep learning for estimating target properties from spectra, without considering simpler alternatives such as partial least-squares (PLS) regression. ...
Mass spectrometry imaging in the earth sciences-A tutorial to the micrometer-scale mapping of molecular fossils via MALDI FT-ICR MS [0.03%]
地球科学中的质谱成像——基于基质辅助激光解析电离傅里叶变换离子回旋共振质谱的分子化石微米级成图教学性文章
Yannick Zander,Weimin Liu,Jannis Viola et al.
Yannick Zander et al.
Mass spectrometry imaging (MSI) is widely used in biomedical sciences, as well as in plant sciences or microbiological studies. However, it is much less prominent in the earth sciences, despite holding enormous potential. For example, marin...