Bottom-up structural analysis of amides by identifying collision-induced dissociation fragment ions: An application in bile acid-amino acid conjugates-targeted sub-metabolome profiling [0.03%]
基于碰撞诱导解离碎片离子识别的酰胺类化合物自下而上的结构解析及其在胆酸-氨基酸共轭物靶向亚代谢组学中的应用研究
Yuxuan Zhou,Wei Li,Xiaoya Niu et al.
Yuxuan Zhou et al.
Background: Amide serves as the key functional group for several chemical families, such as proteins, peptides, amides, and amino acid-conjugated bile acids (AA-BAs), and the featured fragment ions (e.g., a+/-, b+/-, c+/-...
Comprehensive evaluation of dual-mode LC-MS conditions for enhanced metabolomic profiling: Application to microplastic exposure studies [0.03%]
全面评估双模式LC-MS条件以增强代谢组学谱分析：微塑料暴露研究中的应用
Kuan-Lu Wu,Pei-Chen Lin,Wei-Chen Lin et al.
Kuan-Lu Wu et al.
Polystyrene microplastics (PS-MPs) are emerging contaminants of concern due to their potential health impacts and widespread presence in the environment. Metabolomics offers a powerful approach to investigate biological responses to such ex...
Eco friendly core-shell particles coated with molecularly imprinted polymers for S-metolachlor recognition and separation [0.03%]
基于分子印迹聚合物的核壳粒子的制备及其识别和富集S-甲草胺研究
Dominika Rapacz,Katarzyna Smolińska-Kempisty,Joanna Wolska
Dominika Rapacz
Background: The presence of a variety of micropollutants in aquatic environments is currently resulting in a significant degree of deterioration in water quality. Furthermore, these micropollutants can be found in concent...
A SERS aptasensor based on Au@Ag bimetallic nanostars-magnetic covalent organic composites for rHuEPO-α detection [0.03%]
一种基于Au@Ag纳米星状磁性共价有机复合材料的SERS适配子传感器检测rhuepo-α
Na Zhou,Yu Zeng,Qiuwen Huang et al.
Na Zhou et al.
Background: The misuse of recombinant human erythropoietin-alpha (rHuEPO-α) for performance enhancement in sports has been a persistent issue. The World Anti-Doping Agency has emphasized the need for reliable detection m...
Hazards of using multivariate curve resolution for processing first-order spectral data. A rotational ambiguity analysis [0.03%]
多元曲线解析法处理一阶光谱数据的旋转歧义性及其危险性分析研究
Alejandro C Olivieri
Alejandro C Olivieri
Background: A growing number of reports are discussing the use of multivariate curve resolution - alternating least-squares (MCR-ALS) to process matrices built with first-order data, e.g., spectra. Although the results ar...
Optimizing data analysis for broadband mid-infrared absorption spectroscopy: A hybrid dataset approach [0.03%]
宽带中红外吸收光谱数据优化分析：一种混合数据集方法
Roderik Krebbers,Laurens A Æ Sluijterman,Joris Meurs et al.
Roderik Krebbers et al.
Background: Broadband mid-infrared spectroscopy for gas sensing is a rapidly progressing field with a main frontier in novel mid-infrared ultra-broadband laser sources. These sources provide increasingly complex and high-...
Method for screening near-infrared quantitative models with high robustness [0.03%]
一种鲁棒性高的近红外定量模型筛选方法
Zhuopin Xu,Xiaohong Li,Zhiyi Zhang et al.
Zhuopin Xu et al.
Background: It is a common issue that the prediction results of near-infrared (NIR) calibration models are sensitive to changes in measurement conditions. Many existing chemometric algorithms focus on optimizing the accur...
Live-cell imaging of β-galactosidase based on a quinoline-malononitrile-derived AIE probe [0.03%]
基于喹啉-丙二腈衍生物的AIE探针的β-半乳糖苷酶活细胞成像
Shadi Ali Hassen Ahmed,Xue Gao,Yi Zheng et al.
Shadi Ali Hassen Ahmed et al.
Background: Human β-galactosidase (β-gal) is a lysosomal enzyme responsible for the hydrolysis of glycoconjugates, which is overexpressed in primary ovarian cancers and regarded as a biomarker. Therefore, it is of great...
Monitoring the degree of in-source phospholipid fragmentation during MALDI mass spectrometry imaging [0.03%]
在基质辅助激光解吸电离质谱成像过程中监测基质内源性卵磷脂碎片的程度
Samantha L Cousineau,Mohammed H Sarikahya,Kristina Jurcic et al.
Samantha L Cousineau et al.
Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a powerful tool for tissue lipid analysis. Yet, the validity of fatty acid (FA) signals is often questioned due to the potential of in-source lipid fragmen...
Metal-organic frameworks in sample preparation for clinical applications - A review [0.03%]
用于临床应用的金属有机骨架样品制备综述研究
Idaira Pacheco-Fernández,Hélder A Santos
Idaira Pacheco-Fernández
Background: The sample preparation step is one of the main challenges in clinical analysis considering the complexity of the biological samples. Exploring new materials as extraction phases is one of the main strategies t...