Faster, simpler, and more precise calibration curves: Expanding the scope of continuous calibration [0.03%]
更快、更简便和更精确的校准曲线：连续校准的应用范围扩大
Peter J H Williams,Nadini Thushara,Amin Yousefi et al.
Peter J H Williams et al.
Background: Accurate calibration curves are essential for quantitative analysis but are often neglected due to their time, cost, and labour demands. Traditional calibration involves measuring solutions of known concentrat...
Activity-tunable bimetallic iron-cobalt nanoflowers integrated with smartphones for rapid detection of human uric acid [0.03%]
一种与智能手机集成的具有活性可调性的铁-钴双金属纳米花用于快速检测人尿酸
Rou Cheng,Ziyi Guo,Zhengyue Xiao et al.
Rou Cheng et al.
Background: Uric acid (UA), a key biomarker linked to diseases like gout and Alzheimer's, can be detected using nanozyme technology. Developing sensitive nanozyme-based biosensors for UA is therefore crucial for early dis...
Preparation of styrene-maleic anhydride copolymer nanobrush chromatographic stationary phase and its application in phospholipid analysis of exosomes [0.03%]
用于外泌体磷脂分析的 styrene-maleic anhydride 无修饰共聚物纳米刷色谱固定相的制备及应用研究
Ping Wang,Meijuan Xue,Xinhui Guan et al.
Ping Wang et al.
Background: Phospholipids in serum exosomes are promising biomarkers for breast cancer diagnosis. However, the separation of phospholipids by liquid chromatography presents several challenges due to their inherent structu...
Mechanistic insight into Pb2+ sensing by gallic acid-capped gold nanoparticles via SP-ICP-MS and complementary techniques [0.03%]
基于SP-ICP-MS和多种表征手段的棓酸修饰金纳米粒子检测Pb2+的机理研究
Atitaya Suratsawadee,Jitapa Sumranjit,Atitaya Siripinyanond
Atitaya Suratsawadee
Background: Lead (Pb2+) contamination in water is a major environmental and public health concern, creating a demand for sensitive, simple, and field-deployable detection methods. Gold nanoparticles capped with gallic aci...
Development of a double-spike procedure for correcting isotopic fractionation induced during sample preparation and measurement of inorganic mercury isotope ratios by gas chromatography coupled to multicollector ICP-MS [0.03%]
一种校正样品制备和气相色谱-多接收器ICP-MS测定无机汞同位素比率过程中引起的同位素分馏效应的双峰值法的发展研究
Laura Suárez-Criado,Pablo Rodríguez-González,José Ignacio García Alonso
Laura Suárez-Criado
Background: Mercury stable isotope analysis is a powerful tool for tracing Hg sources and transformation processes in the environment. However, Hg species-specific isotope ratio measurements remain challenging due to low ...
Assessing variable importance stability using resampling strategies to enhance model interpretability and reliability in metabolomics [0.03%]
基于重塑策略评估变量稳定性以增强代谢组学模型的可解释性和可靠性
Julien Boccard,Serge Rudaz
Julien Boccard
Background: As a cornerstone of knowledge discovery in metabolomics, multivariate analysis enables the evaluation of relationships between variables, such as measured signals, and observed objects or samples, thereby faci...
Chemical reaction kinetics regulated dual-signal sensing system for discriminating EV-A71 and CV-A16 [0.03%]
一种基于化学动力学反应的双信号传感系统区分肠道病毒EV-A71和CV-A16
Tongtong Ye,Wenjing Xu,Ruohan Tang et al.
Tongtong Ye et al.
A dual-signal system was developed to detect Enterovirus A71 (EV-A71, TEV) and Coxsackievirus A16 (CV-A16, TCV), leveraging the regulatory mechanisms of chemical reactions. MOFFe acts as a catalyst, MOFCr as a Fe2+ reservoir. Specific DNA s...
DrPISA: Deep eutectic solvent-assisted reverse proteome-integrated solubility alteration for high-sensitivity drug target identification [0.03%]
基于深度配位溶剂的反向蛋白质组学集成溶解度改变的高灵敏度药物靶点鉴定法
Liu Yang,Tian-Bo Ma,Chen-Wan Guo et al.
Liu Yang et al.
Background: Thermal stability-based proteomic strategies, including thermal proteome profiling (TPP) and proteome integral solubility alteration (PISA), enable proteome-wide target identification but predominantly analyze...
A dual-locked and self-feedback CHA-DNAzyme nanomachine for tumor-specific molecular imaging in living cells [0.03%]
用于活细胞内肿瘤特异性分子成像的双重锁定和自我反馈的CHA-DNAzyme纳米机器
Baizong Fang,Wei Guo,Zhenyu Liu et al.
Baizong Fang et al.
Background: The detection and imaging of intracellular biomarkers can provide important information for the early diagnosis of cancer. Leveraging the inherent advantages of DNA such as biocompatibility, ease of synthesis,...
A tandem approach for simultaneous detection of toxic hydrazine and phosgene in the environment [0.03%]
一种同时检测环境中有毒肼和光气的串联方法
Natarajan Vijay,Gopal Balamurugan,Thirumalaivasan Natesan et al.
Natarajan Vijay et al.
Background: Improper industrial disposal of toxic chemicals threatens ecosystems, particularly hydrazine used in plastics, pesticides, and polymers with a 1 ppm exposure limit, and phosgene a fast-acting toxic gas causing...