Enhancing ECL efficiency of tris (bipyridine) ruthenium via amino-group-tuned Pd-MOFs for competitive detection of glypican-3 [0.03%]
通过胺调节的Pd-MOFs增强三（联吡啶）钌的ECL效率以竞争性检测甘皮蛋白-3
Ling-Yi Su,Wen Liu,Jing-Yi Bao et al.
Ling-Yi Su et al.
Nowadays, efficient electrochemiluminescence (ECL) emitters are urgently demanded to enhance the biosensor's sensitivity. In this work, we selected Pd-based metal organic frameworks (Pd-MOFs) as nanocarrier to assemble with tris (bipyridine...
Multiple amplifications of NIR-I ECL signals of Au6PtAg nanoclusters and applications in fast detections of noradrenaline [0.03%]
NIR-I区ECL信号的Au6PtAg纳米团簇多级放大及其在快速检测去甲肾上腺素中的应用
Fanfan Guo,Yuanyuan Hu,Huiwen Zhou et al.
Fanfan Guo et al.
NIR-I electrochemiluminescence (ECL) is emerging as highly sensitive detection strategy due to its low background at the ambient conditions. Nonetheless, the applications of current NIR-I ECL nanoprobes are limited to the harsh synthetic/te...
Semiquantitative model for chemometric detection of Brazilian cachaça adulterated with ethanol fuel: A portable near infrared-based approach [0.03%]
基于便携式近红外的巴西卡莎萨酒掺假检测的半定量模型研究
Ana Carolina da Costa Fulgêncio,Emanuel Felipe Souza Silva,Bruno Gonçalves Botelho et al.
Ana Carolina da Costa Fulgêncio et al.
This study presents the development and validation of a rapid and direct chemometric method for detecting the adulteration of cachaça, a typical Brazilian spirit made from fermented and distilled sugarcane juice, with ethanol fuel using a ...
Andreu L López-Juan,Anne Oldeide Hay,Frederik André Hansen et al.
Andreu L López-Juan et al.
Background: Three-phase liquid membrane extraction (LME) of acids involves mass transfer from an acidified sample, through an organic liquid membrane into an alkaline aqueous acceptor. However, this approach presents chal...
Controlling aggregation-induced emission of iridium(Ⅲ) complexes via molecular hydrophilic-lipophilic interactions and in-situ electrostatic self-assembly [0.03%]
通过分子亲水亲脂相互作用和原位静电自组装控制铱(III)配合物的聚集诱导发光
Zhongming Song,A Shengran,Jialong Wu et al.
Zhongming Song et al.
Exploring the internal relationship between the structure and properties of AIE-active iridium complexes and their applications have been great significance. It is imperative to acknowledge that the precise control of nanoparticle morpholog...
Identification of oligonucleotide drug impurities using heart-cutting two-dimensional liquid chromatography-tandem mass spectrometry (2D-LC-MS/MS) [0.03%]
基于二维液相色谱-串联质谱的寡核苷酸药物杂质识别技术
Shiwen Zhou,He Tang,Lu Gao et al.
Shiwen Zhou et al.
Background: Oligonucleotide-based drugs have gained significant attention as a promising class of therapeutics due to their precise ability to regulate gene expression. However, the presence of impurities in these drugs c...
Microwave-modified pencil lead molecularly imprinted polymer coating as SPME fiber for ketoprofen bioanalysis and pharmacokinetic study; A rapid and mass-produced microwave-assisted polymerization [0.03%]
微波改良铅笔芯分子印迹聚合物涂层萃取纤维的制备及其在ketoprofen生物分析和药代动力学研究中的应用；一种快速且可大量制备的微波辅助聚合方法
Nastaran Fallahpour,Atefeh Charabeh,Bahram Ebrahimi
Nastaran Fallahpour
Background: In recent decades, introducing new fibers has improved the SPME method. Commercial fibers are expensive, have low stability and selectivity, and usually sorption occurs by non-selective mechanisms. Various tec...
Enhanced detection of crowded NMR peaks using longitudinal multi-spin order for chemical analysis [0.03%]
利用纵向多自旋序增强拥挤的核磁共振峰的检测以进行化学分析
Yulan Lin,Wei Liang,Longxiang Chen et al.
Yulan Lin et al.
Background: High-resolution one-dimensional (1D) nuclear magnetic resonance (NMR) spectroscopy plays a critical role in enabling the detail analysis of complex samples, precise determination of molecular structures, and i...
Untargeted lipidomic deep-profiling of human plasma via high-performance aza-Prilezhaev aziridination-LC-MS: Unraveling CC isomeric signatures of Charcot-Marie-Tooth disease [0.03%]
高性能氮杂普里列扎耶夫重氮环化-液相色谱质谱法对人血浆进行未靶向脂组深度分析：揭示遗传性感觉运动神经病的CC异构体标志物
Yuling Li,Weiran Zhao,Xiang Xiang et al.
Yuling Li et al.
Background: Perturbed lipid metabolism in cellular environment plays an essential role in the progression of peripheral neuropathy, such as Charcot-Marie-Tooth disease type 1A (CMT1A). Current deep-profiling of lipidome s...
A novel approach for quantifying therapeutic monoclonal antibodies in blood through liquid chromatography-tandem mass spectrometry [0.03%]
一种通过液相色谱-串联质谱法定量血液中治疗性单克隆抗体的新方法
Tsun-Hao Chi,Chiao Lo,Shin-Yi Lin et al.
Tsun-Hao Chi et al.
Background: Therapeutic monoclonal antibodies (mAbs) are increasingly used in clinical practice, but treatment efficacy varies, and high costs remain a concern. Therapeutic drug monitoring (TDM) with personalized dose adj...