Potentiometric, UV and 1H NMR study on the interaction of penicillin derivatives with Zn(II) in aqueous solution [0.03%]
电位法，紫外光谱及 proton NMR 研究水溶液中青霉素衍生物与锌(Ⅱ)的相互作用
Paola Cardiano,Rosalia Maria Cigala,Francesco Crea et al.
Paola Cardiano et al.
The interaction of Zn(II) with ampicillin [(2S,5R,6R)-6-([(2R)-2-amino-2-phenylacetyl]amino)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2- carboxylic acid] and amoxicillin [(2S,5R,6R)-6-{[(2R)-2-amino-2-(4-hydroxyphenyl)-acetyl]am...
The role of loops and cation on the volume of unfolding of G-quadruplexes related to HTel [0.03%]
与HTel相关的G-四联体展开过程中环和阳离子对体积的作用
Yang Yun Li,David N Dubins,Dianna My Nhi Thi Le et al.
Yang Yun Li et al.
In aqueous solutions containing sodium or potassium cations, oligodeoxyribonucleotides (ODNs) rich in guanine form four-stranded DNA structures called G-quadruplexes (G4s). These structures are destabilized by elevated hydrostatic pressure....
Effect of resveratrol on platelet aggregation by fibrinogen protection [0.03%]
白藜芦醇通过保护纤维蛋白原对血小板聚集的影响
Claudia Bonechi,Stefania Lamponi,Alessandro Donati et al.
Claudia Bonechi et al.
The effect of resveratrol (RSV) in inhibiting platelet adhesion and aggregation, as well as fibrinogen (FBG) conformational changes promoted by epinephrine (EP), were studied, by using complementary experimental techniques. NMR and IR spect...
Signal and binding. II. Converting physico-chemical responses to macromolecule-ligand interactions into thermodynamic binding isotherms [0.03%]
信号与配对。第2部分：将生物大分子与配体相互作用的物理化学响应转换为热力学平衡吸附模型
Wlodzimierz Bujalowski,Maria J Jezewska,Paul J Bujalowski
Wlodzimierz Bujalowski
Physico-chemical titration techniques are the most commonly used methods in characterizing molecular interactions. These methods are mainly based on spectroscopic, calorimetric, hydrodynamic, etc., measurements. However, truly quantitative ...
Signal and binding. I. Physico-chemical response to macromolecule-ligand interactions [0.03%]
信号与配对。第一部分。巨分子配基相互作用的物理化学反应
Wlodzimierz Bujalowski,Maria J Jezewska,Paul J Bujalowski
Wlodzimierz Bujalowski
Obtaining a detailed knowledge about energetics of ligand-macromolecule interactions is a prerequisite for elucidation of the nature, behavior, and activities of the formed complexes. The most commonly used methods in characterizing molecul...
Hydrostatic pressure effect on PNIPAM cononsolvency in water-methanol solutions [0.03%]
PNIPAM共溶性在水-甲醇溶液中的静水压效应
Andrea Pica,Giuseppe Graziano
Andrea Pica
When methanol is added to water at room temperature and 1atm, poly (N-isopropylacrylamide), PNIPAM, undergoes a coil-to-globule collapse transition. This intriguing phenomenon is called cononsolvency. Spectroscopic measurements have shown t...
Simona Graziano,Susana Gonzalo
Simona Graziano
Activating mutations in oncogenes promote uncontrolled proliferation and malignant transformation. Approximately 30% of human cancers carry mutations in the RAS oncogene. Paradoxically, expression of mutant constitutively active Ras protein...
Effects of serum albumin on the degradation and cytotoxicity of single-walled carbon nanotubes [0.03%]
白蛋白对单壁碳纳米管降解及毒性的影响研究
Yun Ding,Rong Tian,Zhen Yang et al.
Yun Ding et al.
Neutrophil myeloperoxidase (MPO) and peroxynitrite (ONOO-) can oxidatively biodegrade carboxylated single-walled carbon nanotubes (SWCNTs). The protein-SWCNTs interactions will play an important role in the degradation and cytotoxicity of n...
Structural analyses of the nucleosome complexes with human testis-specific histone variants, hTh2a and hTh2b [0.03%]
人睾丸特异性组蛋白变体hTh2a和hTh2b的核小体复合物结构分析
Sivaraman Padavattan,Viswanathan Thiruselvam,Toshie Shinagawa et al.
Sivaraman Padavattan et al.
Th2a and Th2b are the testis-specific histone variants highly expressed during spermatogenesis. Approximately 4% of the genome is retained in nucleosomes in mature human sperm, which is enriched at loci of developmental importance. Our rece...
DNA replication and inter-strand crosslink repair: Symmetric activation of dimeric nanomachines? [0.03%]
DNA复制和链间交联修复：二聚纳米机器的对称激活？
Paolo Swuec,Alessandro Costa
Paolo Swuec
Eukaryotic DNA replication initiation and the Fanconi anemia pathway of interstrand crosslink repair both revolve around the recruitment of a set of DNA-processing factors onto a dimeric protein complex, which functions as a loading platfor...