From Markovian to Non-Markovian: Advancing ion channel rate process theory [0.03%]
从马尔可夫过程到非马尔可夫过程：推进离子通道速率理论研究
Yuval Ben-Abu
Yuval Ben-Abu
Ion channels are essential membrane proteins that control ionic flow and cellular electrical activity. While traditional Markovian models have provided insights into channel gating, they fail to capture the memory-dependent dynamics of real...
Next-generation antibacterial cryogels: Berberine-infused smart membranes with molecular docking-guided targeting of MRSA and MDR E. coli [0.03%]
下一代抗菌冷冻凝胶：小檗碱灌注的智能膜，具有分子对接引导的MRSA和MDR大肠杆菌靶向性
Metin Yildirim,Mehmet Cimentepe,Kemal Dogan et al.
Metin Yildirim et al.
Multidrug-resistant (MDR) bacteria have become a significant global concern in recent years, necessitating the development of innovative strategies to combat these pathogens. Berberine, a bioactive alkaloid found in Berberis vulgaris, Berbe...
Redox-dependent structural and thermal stability of HMGB1: A thermodynamic analysis [0.03%]
HMGB1的氧化依赖性结构与热稳定性及其热力学分析
Weronika Malicka,Marten Kagelmacher,Michel W Jaworek et al.
Weronika Malicka et al.
HMGB1 is a highly conserved nuclear protein with functions that depend on its biological environment, which are linked to structural differences in the protein. Inside the cell, HMGB1 adopts a reduced form, regulating DNA transcription. In ...
Raman spectroscopic signatures of amyloid fibrils: Insights into structural and biochemical changes in human tissues [0.03%]
用于研究淀粉样原纤维结构及生物化学变化的拉曼光谱特征：人体组织中的新见解
N S Mohd Nor Ihsan,S F Abdul Sani,L M Looi et al.
N S Mohd Nor Ihsan et al.
Amyloid fibrils, characterized by β-sheet-rich protein aggregates, are closely associated with various diseases. Understanding the structural and biochemical changes in amyloid formation requires detailed characterization of their Raman sp...
Concentration-dependent structural transition of huntingtin protein in Huntington's disease [0.03%]
亨廷顿病中亨廷顿蛋白浓度依赖性结构转变
Ji-Na Yoo,Ha-Neul Kim,Su-Yeon Choi et al.
Ji-Na Yoo et al.
Huntington's disease (HD) is a genetic neurodegenerative disorder caused by the abnormal expansion of the polyglutamine (polyQ) tract (> 35Q) in the first exon of the huntingtin (Htt), HttEx1. This N-terminal fragment tends to form fibrilla...
Effect of pyrimethanil on aβ42 aggregation mechanisms revealed at single entity level and molecular dynamic simulations [0.03%]
基于单分子水平及分子动力学模拟研究piremethanil对Aβ42聚集机制的影响
Nathan Meyer,Nicolas Arroyo,Lois Roustan et al.
Nathan Meyer et al.
This study investigated the impact of pyrimethanil, a fungicide, on the aggregation of amyloid-β 42 (aβ42) peptides in vitro. The findings demonstrated that pyrimethanil accelerated aβ42 aggregation kinetics, as evidenced by thioflavin T...
Integrative approaches to network pharmacology studies in wound healing and bone fracture recovery: A comprehensive review [0.03%]
伤口愈合和骨折恢复的网络药理学研究的综合方法：全面综述
Rizwan Ahamed Najimudeen,Catherin Amaldoss,Aarthi Raghu et al.
Rizwan Ahamed Najimudeen et al.
This review provides a comprehensive exploration of the intricate processes involved in wound healing and bone fracture recovery, delving into the phases and cellular activities that underlie these critical physiological events. The integra...
Lysozyme thermal stability in the presence of cyclodextrins at different pH values [0.03%]
不同pH值下环糊精存在时溶菌酶的热稳定性
A Jessica Díaz-Salazar,Daniel Ondo
A Jessica Díaz-Salazar
In the present study, the primary action of native cyclodextrins (CDs) on lysozyme protein as binding ligand and secondary as aggregation inhibitor were probed. Thermally induced denaturation using differential scanning calorimetry (DSC) wa...
Influence of local ordering in the permeation of Temozolomide through the brain plasmatic membrane [0.03%]
局部排序对替莫唑胺通过血脑屏障渗透的影响
Yanhong Ge,Huixia Lu,Jordi Martí
Yanhong Ge
Temozolomide, a small-molecule drug, is primarily used to treat glioblastoma, a tumor that attacks both the spinal cord and brain. Understanding how Temozolomide interacts with different lipids within the brain cell membrane at the atomic l...
Identification of potential Abl kinase inhibitors using virtual screening and free energy calculations for the treatment of chronic myeloid leukemia [0.03%]
基于虚拟筛选和自由能计算的慢性髓性白血病ABL激酶抑制剂识别研究
Beom Soo Kim,Wookyung Yu
Beom Soo Kim
Abl kinase, particularly the Bcr-Abl fusion protein, is a critical driver of chronic myeloid leukemia (CML) and remain significant therapeutic target in hematologic malignancies. Although first-generation tyrosine kinase inhibitors (TKIs) s...