Associations of accelerated phenotypic aging, genetic risk and lifestyle with incident asthma, subsequent cardiovascular disease and death: A prospective study using multi-state model [0.03%]
表型衰老、遗传风险和生活方式与哮喘发病、后续心血管疾病和死亡的关系：使用多状态模型的前瞻性研究
Fan Liu,Lulu Pan,Hongxian Wu et al.
Fan Liu et al.
Objectives: To investigate the associations of phenotypic age acceleration (PhenoAgeAccel) with the risk of dynamic progression of asthma, and whether genetic risk and lifestyle influence these associations. ...
Heterogeneity and clinician typologies in menopause management: Insights from a European survey and latent class analysis [0.03%]
绝经管理中的异质性和临床医生分类：来自欧洲调查和潜在类别分析的见解
Cennikon Pakpahan,Camil Castelo-Branco;Menopause free-hormone management group of the European Society of Gynecology (ESG)
Cennikon Pakpahan
Objectives: To investigate clinical practice characteristics, perceived barriers, and prescribing typologies in the management of menopause among clinicians, with a particular focus on menopausal hormone therapy (MHT). ...
The midlife health penalty: A systematic review and meta-analysis of loneliness and health-related quality of life in adults aged 40-65 [0.03%]
中年健康代价：孤独和健康相关生活质量的系统评价和meta分析（40至65岁年龄组）
Lawrence E Ugwu,Janine Anthea White,Tintswalo Mercy Hlungwani
Lawrence E Ugwu
Loneliness is a recognised determinant of morbidity and mortality in older populations, but its association with health-related quality of life during middle adulthood remains less clearly defined. This systematic review and meta-analysis q...
Common dermatologic conundrums in breast health: Distinguishing benign from serious conditions [0.03%]
乳腺健康中的常见皮肤难题：区分良性与严重状况
Nethra Srinivasan,Allison T Vidimos
Nethra Srinivasan
Dermatological conditions of the breast encompass a wide range of inflammatory, infectious, and neoplastic disorders. Cutaneous findings in the breast present unique diagnostic challenges for clinicians, particularly in distinguishing betwe...
Frailty and risk of incident psoriasis: Prospective UK Biobank evidence with inflammatory, genetic, and proteomic analyses [0.03%]
脆弱性与银屑病发病风险的关系：来自英国生物样本库的前瞻性证据及炎症、遗传和蛋白质组学分析结果
Peizhi Deng,Zilong Cao,Siyu Yan et al.
Peizhi Deng et al.
Objectives: Frailty is associated with numerous chronic conditions, but its relationship with psoriasis remains poorly understood. This study investigated whether baseline frailty predisposes individuals to incident psori...
Fractional CO₂ laser monotherapy versus combination therapy with vaginal oestrogen for genitourinary syndrome of menopause: A prospective observational cohort study conducted over two years [0.03%]
一项前瞻性观察队列研究：绝经过渡期女性CO₂激光单药治疗与雌激素联合治疗的比较研究报告
Ana Sofia Da Silva,A Alexander Taylor
Ana Sofia Da Silva
Objective: To prospectively evaluate symptom outcomes following micro-ablative fractional carbon dioxide laser therapy for genitourinary syndrome of menopause, and to explore whether concomitant use of topical vaginal oes...
Healthy living concepts and definitions: A systematic review with concept analysis proposing a four-dimensional model [0.03%]
健康生活概念与定义：一种系统综述、概念分析及四维模型构建的提案
Silvia Juliana Trujillo-Cáceres,Zayne M Roa-Díaz,Catalina Paz Figueroa et al.
Silvia Juliana Trujillo-Cáceres et al.
Introduction: Despite numerous definitions and theoretical models, healthy living remains conceptually fragmented, lacking a unified framework capturing its dynamic, multilevel, and life-course nature. We systematically i...
The impact of poor sleep on women's midlife transition: A qualitative study using interpretative phenomenological analysis [0.03%]
关于睡眠不佳对女性人生中期过渡影响的定性研究：采用解释现象学分析法
Monica Mamian Perafan,Ellen Elizabeth Anne Simpson
Monica Mamian Perafan
Background: Sleep disturbance is a common and distressing symptom of the menopausal transition, and the lived experiences of women with regard to its cognitive, emotional, personal, and professional impacts need further e...
The effect of childhood body weight status on cardiovascular disease risk in adulthood: A narrative review [0.03%]
儿童时期体重状态对成人期心血管疾病风险影响的叙述性综述
Pavlos Siolos,Aikaterini Mastoropoulou,Panagiotis Anagnostis
Pavlos Siolos
The prevalence of obesity among children and adolescents is rising alarmingly worldwide; however, its long-term effect on adult cardiovascular health is still underestimated. A considerable body of evidence suggests a detrimental effect of ...
A mechanistic digital twin of ovarian aging integrating follicular dynamics, mitochondrial decline, and lifestyle perturbations [0.03%]
一种整合卵泡动力学、线粒体衰减和生活方式干扰的卵巢衰老机制数字孪生模型
Alexandre Vallée,Anis Feki,Marine Poulain et al.
Alexandre Vallée et al.
Background: Ovarian aging determines reproductive lifespan, yet the mechanisms driving inter-individual variability remain incompletely understood. We developed a mechanistic digital twin to investigate how follicular dyn...