The role of frailty in the association between testosterone levels and mortality risk in older men [0.03%]
血清睾丸激素水平与老年男性死亡率相关性的脆弱性效应分析
Panpan Zhang,Wenzhen Hao,Wen Ji et al.
Panpan Zhang et al.
Background: Testosterone plays an important role in male aging, yet its impact on mortality remains unclear. Frailty, a syndrome of physiological decline, may mediate this relationship. This study investigates the mediati...
Home-based exercise reduces fall risk in older adults with mild cognitive impairment who have sustained a hip fracture: A 6-month randomized controlled trial [0.03%]
基于家庭的锻炼可降低既往髋部骨折的认知轻度受损老年人的跌倒风险：一项为期6个月的随机对照试验
Jordyn Rice,Ryan S Falck,Yeon Soo Seo et al.
Jordyn Rice et al.
Objectives: Falls cause more than 85% of hip fractures in older adults. Older adults with cognitive impairment have been largely excluded from research on people who have sustained a hip fracture. As a consequence, whethe...
Associations of DNA methylation algorithm measures of aging with type 2 diabetes and mortality risk among US older adults [0.03%]
表观遗传衰老时钟与美国老年人2型糖尿病和死亡率的关系
Xuetong Zhao,Chongyu Ding,Hui Zhang et al.
Xuetong Zhao et al.
Background: DNA methylation algorithm values show promise as biomarkers for aging and adverse health outcomes, However, their comparative predictive utility for type 2 diabetes mellitus and its related mortality remains i...
Impact of long-term medication on estrobolome-associated β-glucuronidase and sulfatase activities: Implications for estrogen homeostasis in postmenopausal women [0.03%]
长期用药对雌激素稳态相关酯酶和硫酸酯酶活性的影响：绝经后女性的雌激素平衡意义
María Elena Martínez-Nortes,Concepción Carrascosa-Romero,María Ángeles Ávila-Gálvez et al.
María Elena Martínez-Nortes et al.
Menopause leads to a decline in circulating estrogen levels, increasing cardiometabolic risk, contributing to bone loss, and decreasing quality of life. The estrobolome, a subset of microbes with β-glucuronidase (GUS) and sulfatase activit...
Menopause and multiple sclerosis: A scoping review of symptoms, disease course, and lived experience [0.03%]
围绝经期和多发性硬化症：症状、病程及生存体验的综述研究
Dawn Morgan,Victoria Aviado Flores,Stephanie Buxhoeveden et al.
Dawn Morgan et al.
Menopause influences disease activity in women with multiple sclerosis. This scoping review mapped current evidence on menopause in women with multiple sclerosis across symptom, disease, biological, and lived experience domains. This review...
Risk of thyroid disorders after diagnosis of endometriosis: A 20-year retrospective cohort study [0.03%]
基于20年的回顾性队列研究的子宫内膜异位症后甲状腺疾病的发病风险
Yu-Hsiang Shih,Chien-Hsing Lu,Chia-Chi Lung
Yu-Hsiang Shih
Background: Emerging evidence suggests a potential link between endometriosis and thyroid disorders; however, long-term risks remain understudied. Methods...
Frailty transitions and relevant factors in midlife: A longitudinal analysis of the ELSA cohort with multi-state Markov models [0.03%]
中年脆弱性转变及影响因素的纵向分析：基于多状态马尔科夫模型的ELSA队列研究
Jinzhu Yang,Mingyue Gao,Linjun Jiang et al.
Jinzhu Yang et al.
Background: Frailty is an ageing-related health condition, but it is not restricted to older adults. Understanding the characteristics of frailty transitions and relevant factors in midlife would benefit frailty preventio...
Bidirectional transitions of depressive symptoms among middle-aged and older Chinese adults: A multi-state Markov model analysis [0.03%]
中国中老年人抑郁症状的双向转变：多状态马尔可夫模型分析
Junmin Zhu,Chongtao Wei,Yafei Wu et al.
Junmin Zhu et al.
Objective: Evidence on bidirectional transitions of mid- to late-life depressive symptoms and their determinants remains limited. This study aimed to characterize the progression and remission of depressive symptoms in Ch...
Efficacy and safety of daridorexant for the treatment of insomnia disorder in women of menopausal transition age: Insights from a randomized controlled trial [0.03%]
daridorexant治疗围绝经期妇女失眠障碍的有效性和安全性：一项随机对照试验的启示
Zoe Schaedel,Talitha R Bakker,Claudio Bassetti et al.
Zoe Schaedel et al.
Objectives: To evaluate the efficacy and safety of daridorexant in women aged 47-55 years with insomnia disorder, an age group representative of the menopause transition. ...
Postmenopausal labial adhesion: A 5-stage classification system and clinical outcomes in a 14-patient series [0.03%]
绝经后大阴唇粘连的5级分类系统及连续14例患者的临床转归
Ruben F Ibanez,Moises Fernandez,Parvathy Palavoor Naduvakkat et al.
Ruben F Ibanez et al.
Objectives: To characterize postmenopausal labial adhesion, or vulvovaginal obliteration, as the end stage of genitourinary syndrome of menopause, propose a standardized 5-stage classification system, and evaluate outcome...