(Deep) eutectic solvents in chromatographic and electromigration techniques [0.03%]
色谱和电迁移技术中的(e深)eutectic溶剂
Qi Zhang,Haoxiang Meng,Song Xue et al.
Qi Zhang et al.
(Deep) eutectic solvents ((D)ESs) have been recognized as a promising class of designer solvents for separation science, offering unique physicochemical properties and structural versatility beyond those of conventional solvents. Their inte...
Rapid separation and enrichment of emodin and rhein in Sanhuang Xiexin Decoction by molecularly imprinted nanoparticles and evaluation of DPP-4 inhibitory activity [0.03%]
分子印迹纳米粒子快速分离与富集桑皮泻心汤中大黄素和大黄酸并评价DPP-4抑制活性
Chuangchuang Cao,Yue Li,Jingjing Qi et al.
Chuangchuang Cao et al.
To achieve efficient separation of emodin and rhein, a double-template Fe₃O₄-imprinted polymer (DT-MIP@Fe₃O₄) was successfully synthesized. The characterization (FT-IR, XRD, TGA, SEM, TEM, VSM) demonstrated that the synthesized DT-MIP@F...
A novel solid-phase extraction approach based on π-conjugated polymer-functionalized mesoporous silica nanoparticles for isoquinoline alkaloid purification from Cinnamomum camphora seed kernels [0.03%]
基于共轭聚合物功能化的介孔二氧化硅纳米粒子的固相萃取技术在月桂子仁中异喹啉生物碱分离纯化中的应用研究
Yujing Yang,Ping Yu,Zheling Zeng et al.
Yujing Yang et al.
A new class of π-conjugated polymer-functionalized porous silica adsorbents, including a non-carbonized material (SiO2@π-CP) and its carbonized derivative (SiO2@C-π-CP), was developed through a simple, low-cost synthetic strategy. For th...
Superhydrophobic fluorinated microporous microsphere stationary phase for liquid chromatography separation of highly polar pyrimidine compounds under water mobile phase [0.03%]
用于水中流动相分离高度极性嘧啶类化合物的超疏水型含氟微孔微球液相色谱固定相
Xiaomeng Wang,Siyu Wang,Xinrui Xu et al.
Xiaomeng Wang et al.
Fluorous chromatography traditionally relies on large volumes of toxic organic solvents as mobile phase, conflicting with sustainable development principles. Here, we introduce a superhydrophobic fluorinated microporous microsphere stationa...
Comprehensive profiling of alkaloids in Buxus sinica by integrating global natural products social molecular networking with derivatization-assisted characteristic ion filtering [0.03%]
基于导出化-特征离子过滤及全球天然产物社交分子网络的Buxus sinica生物碱类成分综合轮廓分析研究
Sen Li,Song Wang,Zhongzhe Cheng
Sen Li
Comprehensive characterization of alkaloids in Buxus sinica (B. sinica) is hindered by extensive structural diversity, high isomeric complexity, and generally poor ionization efficiency in mass spectrometry. In this study, an integrated LC-...
A green sample preparation strategy for Cl and S determination in crude oil by ion chromatography [0.03%]
一种原油中氯硫含量分析的离子色谱绿色前处理策略
Rochele S Picoloto,Roger U Pinto,Mariele S Nascimento et al.
Rochele S Picoloto et al.
A fast, eco-friendly, and straightforward method was developed for digesting crude oil using microwave-induced combustion (MIC), followed by Cl and S determination by ion chromatography (IC). The procedure involves directly weighing the cru...
Ultrasensitive and multi-analyte detection of catecholamines in serum and cerebrospinal fluid using carboxyl-modified magnetic microspheres coupled with LC/MS [0.03%]
羧基修饰的磁性微球结合LC/MS技术检测脑脊液和血清中儿茶酚胺类物质的新方法研究
Lin Zhao,Ruike Zhang,Liang He et al.
Lin Zhao et al.
Catecholamines (CAs) are crucial markers of several disease. However, the existing method cannot afford enough target analytes and sufficient sensitivity. This study developed a new kind of carboxyl-functionalized hydrophilic lipophilic bal...
Simultaneous quantification of 18 serum steroids and catecholamines via LC-MS/MS: A derivatization-free method using mixed-mode SPE and PFP chromatography [0.03%]
一种无需衍生化的混合模式固相萃取和全氟丙烯酸色谱法，通过LC-MS/MS同时定量十八种血清甾体和儿茶酚胺类化合物的方法
Yingfeng Gao,Yi Zhang,Xin Meng et al.
Yingfeng Gao et al.
The quantification of serum steroids and catecholamines is essential for the clinical diagnosis of adrenal diseases and tumors. Due to their distinct physicochemical properties and low serum concentrations, existing assays typically quantif...
Ultrasonic assisted micellar extraction and in situ cloud point enrichment of terpenoids in complex matrices using poloxamer as a novel surfactant [0.03%]
聚氧乙烯-p-聚氧丙烯嵌段共聚物辅助超声微乳萃取及原位富集复杂基质中的倍半萜类化合物研究
Shi-Qi Niu,Qi-Zhong Jin,Kai-Yang Fan et al.
Shi-Qi Niu et al.
A novel, green, and efficient micellar extraction and in situ cloud point enrichment technique based on poloxamer was developed to simultaneously extract and concentrate terpenoids from Curcumae Rhizoma. The parameters that affect the extra...
Comprehensive evaluation of the analytical toolbox for commercial cysteine-linked antibody-drug conjugates [0.03%]
全面评估商业半胱氨酸连接的抗体药物偶联物的分析工具箱
Elsa Wagner,Jonathan Maurer,Laurence Zanna et al.
Elsa Wagner et al.
The aim of this study was to evaluate the applicability of a broad range of analytical strategies for the detailed characterization and assessment of critical quality attributes (CQAs) of five cysteine-linked antibody-drug conjugates (ADCs)...