Sensitive high-performance thin-layer chromatography-acetylcholinesterase inhibition assay combined with S9 metabolization and high-resolution mass spectrometry for effect-directed analysis of food contact materials [0.03%]
一种结合S9代谢和高分辨率质谱的敏感且高性能的薄层色谱-乙酰胆碱酯酶抑制联用技术，用于食品接触材料的效果导向分析
Ebrahim Azadniya,Kathrin Billerbeck,Gertrud E Morlock
Ebrahim Azadniya
Effect-directed assay detection can prioritize potentially neurotoxic compounds within the vast chemical space of complex mixtures. For previously unknown (unknown unknowns) and chemically unidentified substances, a sensitive effect-directe...
QSRR-based insights into the chromatographic behaviour of phenolic derivatives on biomimetic stationary phases [0.03%]
基于QSRR的生物模拟固定相手性色谱行为表征及机制研究
Yash Raj Singh,Roberto Laganà Vinci,Katarzyna Ewa Greber et al.
Yash Raj Singh et al.
A quantitative structure-retention relationship (QSRR) approach was employed to investigate the chromatographic behaviour of phenolic derivatives on biomimetic stationary phases. The study aimed to elucidate the molecular determinants gover...
Uncovering the origin of impurities in supercritical fluid chromatography coupled to high-resolution mass spectrometry [0.03%]
超临界流体色谱与高分辨质谱联用中的杂质来源探究
Azemina Bajramova,Evangelos Synefakis,Jesper Larsen et al.
Azemina Bajramova et al.
Maintaining low background levels is essential for analytical instruments, such as in supercritical fluid chromatography (SFC) coupled to high-resolution mass spectrometry (HRMS). An approximate tenfold increase of the background was observ...
Imidazolium-based ionic conjugated microporous polymer as a versatile SPE adsorbent for trace triazine herbicides in water and juice samples [0.03%]
基于咪唑𬭩的离子共轭微孔聚合物作为水和果汁样品中痕量三嗪除草剂固相萃取吸附剂的研究
Na Li,Ying-Jie Hao,Wanlu Mu et al.
Na Li et al.
Efficient monitoring of triazine herbicide residues is essential for safeguarding environmental and food safety. In this work, an innovative imidazolium-functionalized ionic conjugated microporous polymer (Im-CMP) was developed through Sono...
Practical considerations for optimizing untargeted metabolomics with Synapt XS HRMS: A tutorial [0.03%]
基于Synapt XS高分辨率质谱的未靶向代谢组优化分析实践及教程
Lars Kaiser,Oliver Riester,Hans-Peter Deigner
Lars Kaiser
Metabolomics, the systematic study of small molecules in biological samples, has rapidly emerged as a key discipline for understanding metabolism across organisms. LCHRMS displays the dominant technique for global metabolomics due to its hi...
Quantification of 3,5-di-tert-butyl-4-hydroxystyrene migrating from organic materials in contact with drinking water: True occurrence or analytical artefact? [0.03%]
3,5-二特丁基-4-羟苯乙烯从与饮用水接触的有机材料中迁移出来的定量：真实发生还是分析异常？
Cynthia Kalweit,Sabrina Berger,Thomas Rapp
Cynthia Kalweit
The occurrence of 3,5-di‑tert‑butyl‑4-hydroxystyrene (S.I) diffusing from cross-linked polyethylene (PE-X) pipes has been a topic of debate among industries, regulatory authorities, and scientists due to inconsistent findings. This study...
Synthesis of quaternized PAMAM-grafted magnetic carbon nanotubes as anion exchange adsorbent for highly efficient and rapid extraction of non-steroidal anti-inflammatory drugs from environmental waters [0.03%]
合成季𬭸化PAMAM-g磁性碳纳米管作为阴离子交换吸附剂高效快速提取环境水中的非甾体抗炎药
Irshad Hussain,Nadeem Muhammad,Liu Shijiang et al.
Irshad Hussain et al.
Extensive prescription and consumption of non-steroidal anti-inflammatory drugs (NSAIDs) in humans and livestock medicines lead to their constant discharge into the natural waters posing deleterious ecological and health concerns. Consideri...
A copper substitution approach for the selective analysis of chlorophyll-derived porphyrins in modern geological and environmental samples [0.03%]
一种铜替代方法，用于现代地质和环境样品中叶绿素衍生成脎的分析
Ruochen Yang,Xiaowei Xia,Junyang Chen et al.
Ruochen Yang et al.
The input of chlorophyll provides key information for reconstructing paleoproductivity and tracing diagenesis in geological matrices. However, accurate analysis is hampered as chlorophyll readily suffers from demetallation and carbon-chain ...
Optimization of Zanthoxylum bungeanum essential oil extraction based on response surface methodology and machine learning with activity evaluation [0.03%]
基于响应面法和机器学习的山椒精油优化提取及其活性评价研究
Jingjin He,Ziqi Zhu,Xinmin Pan et al.
Jingjin He et al.
This study extracted Zanthoxylum bungeanum essential oil via steam distillation, with the extraction process optimized using Response Surface Methodology (RSM) and machine learning techniques. The results indicated that the optimal conditio...
A chromatographic approach to avoid the matrix effect caused by sodium acetate clusters in the liquid chromatography coupled with electrospray ionization mass spectrometry analysis of free fatty acids in human plasma [0.03%]
一种色谱法避免醋酸钠结块导致的基质效应用于人血浆中游离脂肪酸LC-ESI-MS分析
Yuki Fukushima,Kazuhiro Yamamoto,Koichi Machida et al.
Yuki Fukushima et al.
Liquid chromatography coupled with electrospray ionization mass spectrometry (LC-ESI-MS) is widely used for the analysis of biological samples in pharmacokinetic studies, clinical diagnostics, and therapeutic drug monitoring. However, matri...