A simple and sensitive QuEChERS-based LC-MS/MS method for quantifying 30 per- and polyfluoroalkyl substances (PFAS) in human serum: application to firefighter biomonitoring [0.03%]
一种简单灵敏的QuEChERS基LC-MS/MS方法用于定量测定人体血清中30种含氟有机物(PFAS)：消防员生物监测的应用
Crystal L Sweeney,Royin Suwanratanabus,Neda Seyedsadjadi et al.
Crystal L Sweeney et al.
Occupational exposure to per- and polyfluoroalkyl substances (PFAS) is under scrutiny as a potential cancer risk for firefighters. Existing methods for PFAS biomonitoring involve solid-phase extraction (SPE), either conventional or online, ...
PET-modulated fluorescence enhancement of cabergoline: A DFT and time-resolved fluorescence guided analytical strategy [0.03%]
基于DFT和时间分辨荧光引导的Cabergoline与PET基团结合的荧光增强效应的理论研究
Abobakr A Mohamed,Mohamed Ibrahim Halawa,Ahmed Shahboub et al.
Abobakr A Mohamed et al.
A novel, green, and highly sensitive spectrofluorimetric approach for the determination of cabergoline (CG) is presented. The method relied on the strategic modulation of the photoinduced electron transfer (PET) process. The native fluoresc...
Feng Yuan,Sining Li,Min Zhang et al.
Feng Yuan et al.
Microlightning between oppositely charged microdroplets within neutral water droplets imparts unique chemical reactivity. Nevertheless, this phenomenon occurs with limited intensity under common spray conditions, necessitating amplification...
In-situ chargeable, postcharging antibacterial supercapacitor patch with integrated pH sensing for infected chronic wound management [0.03%]
具备集成pH传感功能的就地充电型载药抗菌超级电容器补丁用于感染性难愈合伤口治疗
Yang Zou,Jin Ji,Shengyan Yin et al.
Yang Zou et al.
A major challenge in caring for infected chronic wounds is that conventional antibacterial dressings cannot provide real-time monitoring or on-demand therapeutic intervention. Herein, we report a flexible multifunctional patch that integrat...
Photoactivated liquid-liquid phase separation-based cascade CRISPR/Cas12a electrochemical platform for sensitive small extracellular vesicles detection [0.03%]
基于光激活液-液相分离的级联CRISPR/Cas12a电化学平台用于灵敏检测小细胞外囊泡
Yiping Zhu,Shihua Luo,Min Luo et al.
Yiping Zhu et al.
Small extracellular vesicles (sEVs) have emerged as promising liquid biopsy biomarker for gastric cancer (GC) diagnosis. However, profiling sEVs surface proteins in complex clinical matrices remains challenging by limited sensitivity and hi...
Decoupling human hair isotope codes via mechanistic feature construction and calibrated evidence fusion for uncertainty-aware forensic attribution [0.03%]
基于机制特征构建和校准证据融合的不确定性人发同位素 forensics-attribution 解耦方法
Zhaowei Jie,Jun Zhu,Qing Tao et al.
Zhaowei Jie et al.
Stable isotope analysis of human hair (δ2H, δ18O, δ13C, and δ15N) offers a non-invasive trajectory for geographic sourcing, yet its forensic application remains constrained by overlapping isotopic catchments, individual lifestyle variat...
A light-activated one-pot ERA/CRISPR-Cas12a assay for cost-effective dual-mode detection of HBV DNA [0.03%]
一种低成本检测HBV DNA的光激活一步ERA/Crispr Cas12a检测试剂盒
Xuan Zhou,Lang Wang,XiaoZhen Peng et al.
Xuan Zhou et al.
Light-activatable CRISPR-Cas systems offer an effective strategy to overcome the kinetic incompatibility in one-pot nucleic acid assays; however, their practical application remains limited by high reagent cost, the lack of compatible react...
Sensitive anti-interference trace methane detection system based on novel hollow-core anti-resonant fiber combined with wavelength modulation spectroscopy [0.03%]
一种基于空芯抗共振光纤与波长调制光谱学结合的灵敏型甲烷痕量检测系统
Wenke Zhang,Yungang Zhang,Juncheng Li et al.
Wenke Zhang et al.
Optical spectroscopic detection of methane underpins high-precision greenhouse gas quantification, source tracing and climate mitigation research. Nevertheless, traditional optical gas detection systems rely on free-space optics and discret...
Ultrasensitive and separation-free SERS detection of mitoxantrone in plasma via a charge-selective composite hydrogel [0.03%]
基于电荷选择性复合水凝胶的血液中米托蒽醌免分离SERS超灵敏检测法
Peipei Xu,Junpeng Su,Junhua Zhan et al.
Peipei Xu et al.
Therapeutic drug monitoring (TDM) of mitoxantrone (MIT) is essential for balancing efficacy and toxicity, yet current methods are limited by complex pretreatment, long turnaround times, and matrix interference. Herein, we developed a SERS s...
Upcycling polyethylene terephthalate waste into novel Klebsiella pneumoniae fimbrial adhesin inhibitors: Design, synthesis, and integrated computational and experimental evaluation for drug discovery [0.03%]
聚对苯二甲酸乙二醇酯废物升级回收为新型克雷伯氏肺炎杆菌菌毛黏附素抑制剂：药物设计、合成及计算与实验综合评价
Md Badrul Islam,Sumaiya Jahan Supti,Md Motaher Hossain et al.
Md Badrul Islam et al.
Klebsiella pneumoniae is a major opportunistic pathogen associated with severe nosocomial infections, and its escalating antimicrobial resistance underscores the urgent need for new therapeutic strategies. Targeting fimbrial adhesin protein...