Phenotyping and genotyping for the dihydropyrimidine dehydrogenase test in Italy: a precise diagnostic strategy to detect rare variants and improve drug administration [0.03%]
意大利二氢嘧啶脱氢酶检测表型和基因分型：一种精确的诊断策略，用于识别罕见变异并改进药物使用
Maria Lucia Tommolini,Mirco Zucchelli,Alberto Frisco et al.
Maria Lucia Tommolini et al.
Introduction: Dihydropyrimidine dehydrogenase (DPD) is the enzyme implicated in the catabolism of the fluoropyrimidines (FP), a class of chemotherapeutics used to treat many cancers. The DPYD gene is known to have a huge ...
Elevated level of platelet factor 4 in follicular fluid is associated with polycystic ovary syndrome [0.03%]
卵泡液中血小板因子4水平升高与多囊卵巢综合征有关
Wenqi Wang,Guangxi Wang,Xiaoming Niu et al.
Wenqi Wang et al.
Objective: This present study aimed to measure platelet factor 4 (PF4) protein level in follicular fluid of patients with polycystic ovary syndrome (PCOS) and analyzed the correlation between follicular PF4 level with cli...
Clinical implementation and outcome evaluation of dihydropyrimidine dehydrogenase (DPYD) pharmacogenomic testing for fluoropyrimidine dosing in a Canadian Provincial Healthcare center [0.03%]
二氢嘧啶脱氢酶（DPYD）药物基因组学检测在氟尿嘧啶类药物剂量调整中的临床应用及疗效评估：加拿大省级医疗中心报告
Fang Wu,Song Lu,Dan Zhang et al.
Fang Wu et al.
Background: 5-Fluorouracil (5-FU) and its pro-drug, capecitabine, are widely used to treat solid tumors. Patients with dihydropyrimidine dehydrogenase (DPYD) deficiency are at increased risk for severe treatment-related t...
Leyla Karimova,Gulnara Azizova,Ilaha Shahverdiyeva
Leyla Karimova
Objective: Breast cancer (BC) remains a leading cause of morbidity and mortality among women globally. This study aims to investigate HER2 mutations in HER2-negative BC and evaluate the diagnostic potential of matrix meta...
Method choice for investigation of macrotroponin interference with the Siemens Atellica high sensitivity troponin I assay [0.03%]
西门子Atellica超高敏肌钙蛋白I测定方法的干扰因素调查及对策分析
Amir Karin,Catherine Cheng
Amir Karin
Objectives: Macrotroponin refers to circulating immunoglobulin-bound cardiac troponin species that may elevate troponin results in patients with or without myocardial injury, causing diagnostic confusion. Clinical laborat...
Circulating free PSA in breast cancer patients: is it a reliable biomarker? [0.03%]
乳腺癌患者中的游离PSA：可靠的生物标志物吗？
Vanessa Susini,Maria Franzini,Silvia Ursino et al.
Vanessa Susini et al.
Introduction: Prostate-specific antigen (PSA), a serine protease primarily expressed in the prostate, has also been detected in hormonally regulated female tissues, including the breast. Some studies suggest a correlation...
How effective is serum FGL1 measurement in assessing disease activity: A cross-sectional study in rheumatoid arthritis [0.03%]
评估疾病活动度时血清FGL1检测的有效性：类风湿关节炎患者的横断面研究
Mesut Ates,Merve Ates,Mujgan Gurlerc et al.
Mesut Ates et al.
Introduction: In rheumatoid arthritis, which is an autoimmune inflammatory disease with multisystemic involvement, especially the joints, tracking disease activity is quite valuable in order to improve the quality of life...
Minimizing high sensitivity troponin T delta variation at low concentration using BD Barricor blood collection tube [0.03%]
采用BD Barricor采血管最小化低浓度下高敏肌钙蛋白T的变异系数
Albert K Y Tsui,Jialin Qiu,Isolde Seiden-Long et al.
Albert K Y Tsui et al.
Objective: Reproducible low troponin concentrations from high-sensitivity troponin (hs-cTn) assays are paramount to accurate risk determination in the accelerated diagnostic pathway. Total variation consists of pre-analyt...
Comparison of capillary dried blood spot and capillary microtubes with venous immunoglobulin g levels for routine diagnostics [0.03%]
指尖血干血斑和微量采血管检测免疫球蛋白G结果与静脉血检测结果的对比研究
S L Boland,M J H Doeleman,L G E Hofstee et al.
S L Boland et al.
Background and aims: Patients with primary antibody deficiencies receiving immunoglobulin replacement therapy require frequent monitoring of immunoglobulin G (IgG) levels. Capillary IgG measurements from dried blood spots...
An improved and economical LLE-LC/MS method for quantifying phosphatidylethanol: Identification and separation of isotopic cross-talk in clinical alcohol testing [0.03%]
一种改进的经济型LLE-LC/MS法用于定量分析磷脂乙醇：临床酒精检测中的同位素交叉干扰鉴定及分离
Naga Veera Yerra,Christopher Pini,Carlos Cordon-Cardo et al.
Naga Veera Yerra et al.
Objective: Phosphatidylethanol (PEth) is a group of phospholipids formed in the presence of ethanol on the red blood cell membrane. Due to their stability in blood for 3-4 weeks, they have become reliable direct biomarker...