Defining a clinically relevant thyroglobulin antibody interference threshold for high-sensitivity thyroglobulin immunoassays: a single institution case study [0.03%]
高灵敏甲状腺球蛋白免疫测定临床相关甲状腺球蛋白抗体干扰界值的确定：单中心病例研究
Simmi Patel,Octavia M Peck Palmer,Chanda B Lay et al.
Simmi Patel et al.
Background: The interpretation of serum thyroglobulin (Tg) levels in differentiated thyroid cancer is complicated by interference from thyroglobulin antibodies (TgAb) and there is no standardized threshold to determine in...
Analytical performance and clinical evaluation of CL AIA-PACK® hs-E2, a high-sensitivity estradiol sandwich immunoassay using an anti-immunocomplex antibody [0.03%]
一种高灵敏度雌二醇夹心免疫测定法CL AIA-PACK® hs-E2的性能分析及临床评价
Satoshi Fujimura,Yoko Usami,Akari Yamamoto et al.
Satoshi Fujimura et al.
Introduction: The CL AIA-PACK® hs-E2 (hs-E2) is a high-sensitivity estradiol (E2) sandwich immunoassay employing an anti-immunocomplex antibody. This study aimed to evaluate its analytical performance and clinical utilit...
Gaps in guideline adherence: evaluating HLA-B*57:01 screening for abacavir sensitivity and the implementation of evidence-based HIV care [0.03%]
指南依从性缺口：评估HLA-B*57：01筛查以确定阿巴卡韦敏感性和实施循证HIV护理的情况
Lisa V Kalman,Yang Xia,Ya-Lin A Huang et al.
Lisa V Kalman et al.
Objective: Approximately 5-8 % of the population carries the HLA-B*57:01 allele, which increases the risk of severe hypersensitivity reactions to abacavir. Current guidelines and an FDA black box warning recommend HLA-B*5...
Ionized magnesium-the forgotten strong ion in pediatric critical care [0.03%]
离子化的镁元素——儿科重症监护中被遗忘的强大离子成分
Guido Filler
Guido Filler
Capillary electrophoresis mis-anchoring in a case of Hb hope with HbE [0.03%]
异常血红蛋白Hope合并HbE的毛细管电泳误定位
Victoria Higgins,Natalia Volodko,Michelle L Parker et al.
Victoria Higgins et al.
Background: Capillary electrophoresis is a widely used method for hemoglobin (Hb) fraction separation and relative quantitation, where pre-defined Hb peaks (typically HbA and HbA2) act as reference points to "anchor" the ...
Critical role of laboratory and multidisciplinary strategies in the early diagnosis of acquired haemophilia a for life-saving management [0.03%]
实验室和多学科策略在获得性血友病A早期诊断中的关键作用以及对救命治疗的影响
R Belardi,M Emili,F G Viola et al.
R Belardi et al.
Background: Acquired haemophilia A (AHA) is a rare but potentially life-threatening autoimmune disorder characterized by the development of autoantibodies against coagulation factor VIII (FVIII). It manifests with spontan...
Diagnostic value of serum TSI levels in Graves' disease and direct comparison of diagnostic performance with TRAb: A systematic review and meta-analysis [0.03%]
促甲状腺素受体抗体和甲状腺刺激免疫球蛋白在Graves病诊断中的价值及其直接对比：系统评价和meta分析
Ziyue Jiang,Shouxia Li,Li Yang et al.
Ziyue Jiang et al.
This study aimed to systematically assess the diagnostic value of thyroid-stimulating immunoglobulin on the Siemens Immulite platform (the TSI assay) and to conduct a direct comparison with thyrotropin receptor antibodies on the Roche cobas...
Kevin J Tu,Christina Greever-Wilson
Kevin J Tu
Research funders can play a transformative role in reducing the environmental footprint of science without compromising its quality or productivity. Scientific research is among the most energy- and resource-intensive sectors globally, with...
Best practice guidelines on reference interval harmonization in Canada: Evidence-based recommendations from the CSCC working group on reference interval harmonization (CSCC WG-hRI) [0.03%]
加拿大参考区间统一的最佳实践指南：来自加拿大标准委员会参考区间统一工作组（CSCC WG-hRI）的循证建议
Mary Kathryn Bohn,Dana Nyholt,Cynthia Balion et al.
Mary Kathryn Bohn et al.
Unnecessary variation in reference intervals across clinical laboratories increases the risk of inconsistent or misinformed clinical decision-making. Development of harmonized or common reference intervals for assays that demonstrate minima...
Practice Guideline
Clinical biochemistry. 2025 Aug 3:110986. DOI:10.1016/j.clinbiochem.2025.110986 2025
The biological diagnosis of Alzheimer's disease using blood-based biomarkers: A Canadian prospective [0.03%]
基于血液生物标志物的阿尔茨海默病生物学诊断：加拿大前瞻性研究
Pankaj Kumar,Ali Mousavi,Hans Frykman
Pankaj Kumar
Dementia is the most common type of neurodegenerative diseases, with Alzheimer's Disease (AD) constituting about two-thirds of these cases. In Canada, an estimated 674,000 individuals may have AD by 2031, nearly doubling from 2011. The tota...