Immunogenicity and reactogenicity of fractional vs. full booster doses of COVID-19 vaccines: A non-inferiority, randomized, double-blind, phase IV clinical trial in Pakistan [0.03%]
十万例单价和全剂量新冠疫苗序贯加强免疫非劣效性随机双盲临床试验：巴基斯坦现场试验结果
Huma Syed Hussain,Mohammad Tahir Yousafzai,Junaid Iqbal et al.
Huma Syed Hussain et al.
Background: We evaluated the immunogenicity and safety of fractional doses of SARS-CoV-2 booster vaccines compared to full doses in adults aged 18-60 primed with full series of Sinovac, AZD1222, or Natural Infection in Si...
Post-COVID-19 pandemic inequities in routine childhood immunization in Canada: racial disparities in uptake of polio, meningococcal conjugate, and varicella vaccines [0.03%]
加拿大新冠疫情后的儿童常规免疫不平等：种族差异导致的脊髓灰质炎、脑膜炎球菌结合和水痘疫苗接种率不同
Rose Darly Dalexis,Idrissa Beogo,Yan Xu et al.
Rose Darly Dalexis et al.
Background: Decline in routine childhood vaccination coverage in Canada has accelerated following the COVID-19 pandemic, increasing risks of vaccine-preventable diseases. Yet, little is known about how this affects differ...
Adjuvant properties of baculovirus enhance the immunogenicity and protective efficacy of foot-and-mouth disease virus-like particles vaccines in mice [0.03%]
杆状病毒的佐剂性能增强口足病病毒样的颗粒疫苗在小鼠中的免疫原性和保护效力
Florencia Belén Lobo Gaitán,Román David González-Mora,Sofía Tutti et al.
Florencia Belén Lobo Gaitán et al.
Foot-and-mouth disease (FMD) is one of the most economically relevant livestock diseases worldwide due to the rapid spread of its etiological agent, Foot-and-mouth Disease Virus (FMDV), and the severe economic losses associated with outbrea...
ChAdOx1 nCoV-19 coronavirus vaccine: Long-term safety and immunological responses [0.03%]
ChAdOx1 nCoV-19冠状病毒疫苗的长期安全性和免疫反应
Narges Ebrahimi,Philip de Whalley,Nasir Kanji et al.
Narges Ebrahimi et al.
Rationale: Follow-up of pre-licensure trial participants potentially informs a vaccine's long-term safety profile. Design: This prospec...
Chun-Hsiang Hsu,Chiu-Fan Chen,Kuo-An Chu et al.
Chun-Hsiang Hsu et al.
Introduction: The efficacy and effectiveness of the human papillomavirus (HPV) vaccine in reducing the risk of invasive cervical cancer in females and head and neck cancer (HNC) in males have been demonstrated. However, t...
Timing of maternal Tdap vaccination: A dynamic balance between antibody induction and placental transfer efficiency [0.03%]
孕妇接种Tdap疫苗的时机：抗体诱导与胎盘转移效率之间的动态平衡
Louise De Weerdt,Anaïs Thiriard,Inès Vu Duc et al.
Louise De Weerdt et al.
Background: Tetanus, diphtheria, acellular pertussis (Tdap) vaccination in pregnancy protects newborns against pertussis, but the influence of gestational age (GA) at vaccination on maternal and neonatal immune profiles r...
Oral delivery of recombinant Bacillus subtilis expressing mSEB reduces intestinal Staphylococcus aureus colonization [0.03%]
口服表达mSEB重组枯草芽孢杆菌可减少肠道金黄色葡萄球菌定植
Kaiyue Yang,Yunxing He,Xiaojie Zhou et al.
Kaiyue Yang et al.
Background: S. aureus intestinal colonization elevates infection risk, underscoring decolonization as a key prevention target. SEB is a key target for the development of neutralizing antibodies against toxins to prevent a...
Euzebiusz Jamrozik,Lucie Abeler-Dörner,Amol Chaudhari et al.
Euzebiusz Jamrozik et al.
Nipah virus causes sporadic outbreaks characterized by high mortality, with transmission concentrated within households and healthcare settings. Clinical trials of vaccines for high-mortality pathogens during outbreaks face significant meth...
Efficacy and safety of a non-adjuvanted Bordetella bronchiseptica extract vaccine with recombinant pertactin administered subcutaneously to dogs [0.03%]
皮下给犬注射非佐剂巴氏杆菌支气管炎分离物疫苗与重组保护素 Pertactin 联合免疫的疗效和安全性研究
Sridhar Velineni,Sharon Wappel,Nikki Sobell et al.
Sridhar Velineni et al.
Background: This study aimed to assess the efficacy and safety of the Vanguard® Recombishield™ Injectable Bordetella, a non-adjuvanted Bb extract vaccine containing recombinant pertactin, in dogs using controlled challe...
Joshua Rosenheim,Bonnie Bender,Jill Gilmour et al.
Joshua Rosenheim et al.
Respiratory pathogens cause substantial global morbidity, mortality, and pandemic risk. While parenteral vaccines can effectively reduce severe disease for some respiratory infections, they are often less effective at preventing infection a...