Lung-resident T-cell immunity dominates protection induced by an intranasal adenoviral nucleoprotein influenza vaccine [0.03%]
鼻内腺病毒核酸蛋白流感疫苗诱导的肺部T细胞免疫主导保护作用
Wen-Chien Wang,Marwa Alhashimi,Vivek Gairola et al.
Wen-Chien Wang et al.
Frequent antigenic drift in influenza viruses necessitates broadly protective vaccines. This study evaluated an intranasal adenoviral-vector vaccine expressing influenza A nucleoprotein (NP) fused to the autophagy-inducing peptide C5. A het...
Longitudinal and spatial declines in equine Hendra virus vaccination despite continued risk [0.03%]
马亨德拉病毒的纵向和空间下降以及持续的风险
Belinda Linnegar,Hamish McCallum,Alison J Peel
Belinda Linnegar
Hendra virus is an emerging zoonosis endemic to Australia with high fatality of infection in horses and humans. The role of infected domestic horses as amplifying bridge hosts for onward transmission to humans led to the creation of an equi...
Persistent vaccine-type invasive pneumococcal disease in children despite high PCV13 coverage: the role of serotype 3 [0.03%]
尽管PCV13接种率高，肺炎链球菌侵袭性疾病在儿童中持续流行，血清型3起到什么作用？
Pilar Ciruela,Sonia Broner,Fernando Moraga-Llop et al.
Pilar Ciruela et al.
Background: Despite widespread implementation of pneumococcal conjugate vaccines (PCVs), invasive pneumococcal disease (IPD) caused by vaccine serotypes continues to occur. Evidence on vaccine failure and breakthrough inf...
Real-world effectiveness and safety of protein-based and mRNA COVID-19 vaccines (BEEHIVE trial) [0.03%]
基于蛋白质和基于mRNA的新冠疫苗真实世界有效性和安全性研究（BEEHIVE试验）
Sarang K Yoon,Andrew L Phillips,Steph Battan-Wraith et al.
Sarang K Yoon et al.
Background: Real-world vaccine effectiveness (VE) and relative VE (rVE) data of protein-based and mRNA COVID-19 vaccines against symptomatic SARS-CoV-2 infections inform policy recommendations and reinforce public confide...
A systematic meta-analytic comparative evaluation of seasonal influenza vaccine effectiveness from test-negative design studies in the Northern Hemisphere pre/post COVID-19 pandemic [0.03%]
COVID-19大流行前后期Northern半球季节性流感疫苗效力的系统meta分析比较研究评估
George N Okoli,Sheena G Sullivan,Diane M Harper et al.
George N Okoli et al.
Background: Influenza circulation was substantially reduced during the COVID-19 pandemic. The consequent reduction in population immunity may have resulted in increased influenza vaccine effectiveness (VE) after the pande...
mRNA-LNP hepatitis C vaccine encoding p7 elicits improved humoral immunogenicity [0.03%]
基于p7的mRNA-LNP乙肝疫苗可诱导更强的体液免疫反应
Erin K Reagan,Desiree A Wright,Kaitlyn E Clark et al.
Erin K Reagan et al.
Nucleoside-modified messenger RNA lipid nanoparticle (mRNA-LNP) vaccines have had a tremendous impact on vaccine development against infectious pathogens, particularly since the onset of the COVID-19 pandemic. The platform is an effective s...
Dengue vaccines: The role of a correlate of protection in evaluating vaccine safety and risk [0.03%]
登革热疫苗：评估疫苗安全性和风险的保护相关因素的作用
Joshua M Wong,Parker K Acevedo,Steve Whitehead et al.
Joshua M Wong et al.
Dengue remains a significant global health challenge, with incidence rising and over half the world's population at risk. Vaccines could play an important role in controlling dengue, but without a validated correlate of protection (CoP), va...
Acute intraocular inflammation: Brighton Collaboration case definition and guidelines for data collection, analysis, and presentation of immunization safety data [0.03%]
急性眼内炎症：Brighton合作组织病例定义和免疫安全数据收集、分析及展示指南
Steven Yeh,Wanjiku Mathenge,Jean-Claude Mwanza et al.
Steven Yeh et al.
This is a new Brighton Collaboration (BC) case definition of acute intraocular inflammation (aIOI) which includes one or more of: anterior uveitis, intermediate uveitis, posterior uveitis, panuveitis, retinal vasculitis, and neuroretinitis....
Beyond neutralization: A comprehensive framework for evaluating humoral immunity induced by a live-attenuated tetravalent dengue vaccine [0.03%]
登革热减毒四价疫苗诱导的体液免疫综合评价框架超越了中和作用
Raphael Gottardo,Hansi Dean,Eduardo J M Nascimento et al.
Raphael Gottardo et al.
Objective: Dengue incidence is increasing worldwide. TAK-003, a live-attenuated tetravalent dengue vaccine, is licensed in several countries. Its safety, efficacy, and immunogenicity have been extensively studied and prov...
Is it time to investigate the safety of live-attenuated vaccines during pregnancy? [0.03%]
孕期使用减毒活疫苗的安全性值得关注吗？
Abdelrahman M Makram,Dang Huu Thien,Manuela Bombana et al.
Abdelrahman M Makram et al.