Intranasal immunization with a P1 adhesin C-terminal-flagellin fusion protein elicits robust systemic and mucosal immunity and protects against Mycoplasma pneumoniae infection in a mouse model [0.03%]
鼻内免疫P1粘附素C-末端-鞭毛蛋白融合蛋白疫苗诱导系统性和黏膜免疫应答并保护小鼠免受肺炎支原体感染
Jingni Yang,Tao Lin,Xiangfang Lin et al.
Jingni Yang et al.
Mycoplasma pneumoniae (M. pneumoniae) is a major cause of community-acquired pneumonia. Rising macrolide resistance and limited preventive strategies highlight the urgent need for effective vaccines. A vaccine eliciting robust mucosal immun...
Systemic barriers to achieving yellow fever vaccination coverage targets among children aged 9-23 months in the Democratic Republic of the Congo [0.03%]
影响刚果民主共和国9-23月龄儿童黄热病疫苗接种率的因素分析
Aliocha Natuhoyila Nkodila,Reagan Okingo Luvande,André-Ronz Basilua Nsana et al.
Aliocha Natuhoyila Nkodila et al.
Despite efforts to improve vaccination coverage, many children remain insufficiently protected in sub-Saharan Africa where health systems remain fragile. This study aimed to identify systemic barriers to achieving yellow fever vaccine cover...
Oral immunotherapy with anti-ES24 antibodies reduces burden and fecundity of Haemonchus contortus and inflammation in lambs artificially infected [0.03%]
口服抗ES24抗体免疫疗法可减轻人工感染的羔羊胃肠道中盘尾丝虫的寄生量和促炎反应
Cintia Hiromi Okino,Mateus Oliveira Mena,Emanuelle Martins de Campos et al.
Cintia Hiromi Okino et al.
Increasing multiple anthelmintic resistance in Haemonchus contortus has been reported worldwide, highlighting the need for alternative strategies to mitigate the damage caused by this nematode. In this study, we developed and evaluated an i...
Invasive pneumococcal disease in Latin America: serotype distribution and vaccine coverage among adults in Mexico, Brazil, and Argentina [0.03%]
拉丁美洲侵袭性肺炎球菌病的血清型分布及墨西哥、巴西和阿根廷成人疫苗接种情况概述
Amanda Martino,Juan Urrego-Reyes,Jan Cervenka et al.
Amanda Martino et al.
Background: Invasive pneumococcal disease (IPD) causes substantial morbidity and mortality among adults in Latin America. Despite high pediatric pneumococcal conjugate vaccine (PCV), uptake, adult coverage remains low, an...
Role of civil society organisations in immunisation: A scoping review [0.03%]
民间社会组织在免疫接种中的作用：一项范围回顾研究
Shiva Shrestha,Kerrie Wiley,Adeline Tinessia et al.
Shiva Shrestha et al.
Background/objectives: Civil society organisations (CSOs) are central to reaching zero-dose children and advancing Immunisation Agenda 2030 (IA2030). Yet the evidence on CSO roles is fragmented across settings and CSO typ...
Prioritizing the introduction of new vaccine in Tanzania (2026-2030): a multi-criteria decision analysis by the Tanzania immunization technical advisory group [0.03%]
坦桑尼亚免疫技术咨询小组多准则决策分析优先引入新的疫苗（2026-2030）
Furaha Kyesi,Fausta Michael,Semvua Kilonzo et al.
Furaha Kyesi et al.
Background: The growing need for availability of new vaccines, alongside constrained financial and health system resources, necessitates transparent and evidence-based prioritization. ...
Factors affecting parental practices and attitudes toward influenza vaccination for children in China [0.03%]
影响中国家长的儿童流感疫苗接种行为和态度的因素分析
Zhaohan Wei,Xiaolei Feng,Qin Sun et al.
Zhaohan Wei et al.
Background: Influenza presents a severe health threat to children, and influenza vaccination represents the most cost-effective preventive measure. This study was conducted to investigate parents' knowledge, attitudes, an...
Over-induction of innate immune responses suppresses T cell response to mRNA SARS-CoV-2 vaccination [0.03%]
过度诱导的先天免疫反应会抑制mRNA SARS-CoV-2疫苗接种后的T细胞应答
Carina J X Tay,Clara W T Koh,Justin S G Ooi et al.
Carina J X Tay et al.
SARS-CoV-2 mRNA vaccines elicit robust T cell responses in children, resulting in substantial protection against hospitalisation and severe disease. However, the underlying molecular mechanisms that drive this robust cellular immunogenicity...
Polymorphisms in the Bordetella pertussis virulence factor SphB1 and altered antigen expression of clinical isolates before and after acellular pertussis vaccination in Finland [0.03%]
百日咳疫苗接种前后芬兰临床分离菌株SphB1毒力因子多态性及抗原表达改变
Vili Niinikoski,Anette Myllylä,Alex-Mikael Barkoff et al.
Vili Niinikoski et al.
Background: Bordetella pertussis has adapted significantly following the transition from whole-cell vaccines (WCV) to acellular vaccines (ACV). While changes in vaccine antigens are well-documented, the evolution of proce...
Immunogenicity, reactogenicity, and safety of an mRNA-based seasonal influenza and SARS-CoV-2 multicomponent vaccine, mRNA-1083, in adults aged ≥50 years in Japan [0.03%]
日本老年人群中基于mRNA的季节性流感和SARS-CoV-2多组分疫苗（mRNA-1083）的免疫原性、反应原性和安全性：一项随机对照试验
Lusine Kostanyan,Hiroyuki Fukase,Alexander Rumyantsev et al.
Lusine Kostanyan et al.
A multicomponent vaccine targeting seasonal influenza and coronavirus disease 2019 (COVID-19) may reduce disease burden by providing simultaneous protection in a single injection. We report findings from Part 1 (Japan) of a phase 3, Asia-Pa...