Nicole R Karcher
Nicole R Karcher
The Changing Weight of Expectation: How Shifting Priors Underpin Variability in Hallucination Frequency [0.03%]
预期的重量变化：先验的转变如何导致幻觉频率的变化
Paul Charles Fletcher,Christoph R Teufel
Paul Charles Fletcher
Circuit-Based Approaches to Understanding Corticostriatothalamic Dysfunction Across the Psychosis Continuum [0.03%]
基于 circuits 的方法来理解贯穿精神病谱系的皮质-纹状体-丘脑功能障碍
Kristina Sabaroedin,Jeggan Tiego,Alex Fornito
Kristina Sabaroedin
Dopamine is known to play a role in the pathogenesis of psychotic symptoms, but the mechanisms driving dopaminergic dysfunction in psychosis remain unclear. Considerable attention has focused on the role of corticostriatothalamic (CST) circ...
CREB Binding at the Zfp189 Promoter Within Medium Spiny Neuron Subtypes Differentially Regulates Behavioral and Physiological Adaptations Over the Course of Cocaine Use [0.03%]
CREB在ZFP189启动子中的结合通过中棘神经元亚型在可卡因使用过程中差异调节行为和生理适应性反应
Collin D Teague,Joseph A Picone,William J Wright et al.
Collin D Teague et al.
Background: Over the course of chronic drug use, brain transcriptional neuroadaptation is thought to contribute to a change in drug use behavior over time. The function of the transcription factor CREB (cAMP response elem...
Genomic Stratification of Clozapine Prescription Patterns Using Schizophrenia Polygenic Scores [0.03%]
利用精神分裂症基因分数对氯氮平处方模式进行基因组分类
Djenifer B Kappel,Sophie E Legge,Leon Hubbard et al.
Djenifer B Kappel et al.
Background: Treatment-resistant schizophrenia affects approximately 30% of individuals with the disorder. Clozapine is the medication of choice in treatment-resistant schizophrenia, but optimizing administration and dose ...
Social Synchronization of Conditioned Fear in Mice Requires Ventral Hippocampus Input to the Amygdala [0.03%]
小鼠的社会恐惧条件反射需要腹侧海马向杏仁体的输入
Wataru Ito,Alexander J Palmer,Alexei Morozov
Wataru Ito
Background: Social organisms synchronize behaviors as an evolutionary-conserved means of thriving. Synchronization under threat, in particular, benefits survival and occurs across species, including humans, but the underl...
Michael Browning,Martin Paulus,Quentin J M Huys
Michael Browning
Frank R Wendt,Gita A Pathak,Kritika Singh et al.
Frank R Wendt et al.
Background: The presentation, etiology, and relative risk of psychiatric disorders are strongly influenced by biological sex. Neuroticism is a transdiagnostic feature of psychiatric disorders displaying prominent sex diff...
Matthew V Elliott,Serajh A S Esmail,Kevin S Weiner et al.
Matthew V Elliott et al.
Background: Emotion-related impulsivity (ERI) refers to chronically poor self-control during periods of strong emotion. ERI robustly predicts psychiatric disorders and related problems, yet its neuroanatomical correlates ...
Associations of DNA Methylation With Behavioral Problems, Gray Matter Volumes, and Negative Life Events Across Adolescence: Evidence From the Longitudinal IMAGEN Study [0.03%]
纵向IMAGEN研究中的行为问题、灰质体积和负面生活事件与DNA甲基化的关联性研究
Yan Sun,Tianye Jia,Edward D Barker et al.
Yan Sun et al.
Background: Negative life events (NLEs) increase the risk for externalizing behaviors (EBs) and internalizing behaviors (IBs) in adolescence and adult psychopathology. DNA methylation associated with behavioral problems m...