Cellular Genome-wide Association Study Identifies Common Genetic Variation Influencing Lithium-Induced Neural Progenitor Proliferation [0.03%]
基于细胞的全基因组关联研究发现影响锂诱导的神经干细胞增殖的常见遗传变异
Justin M Wolter,Brandon D Le,Nana Matoba et al.
Justin M Wolter et al.
Background: Bipolar disorder is a highly heritable neuropsychiatric condition affecting more than 1% of the human population. Lithium salts are commonly prescribed as a mood stabilizer for individuals with bipolar disorde...
Diurnal Alterations in Gene Expression Across Striatal Subregions in Psychosis [0.03%]
精神障碍患者纹状体内不同区域基因表达的日节律改变
Kyle D Ketchesin,Wei Zong,Mariah A Hildebrand et al.
Kyle D Ketchesin et al.
Background: Psychosis is a defining feature of schizophrenia and highly prevalent in bipolar disorder. Notably, individuals with these illnesses also have major disruptions in sleep and circadian rhythms, and disturbances...
Circulating Proteins Influencing Psychiatric Disease: A Mendelian Randomization Study [0.03%]
精神病疾病的循环蛋白质的影响：一项孟德尔随机化研究
Tianyuan Lu,Vincenzo Forgetta,Celia M T Greenwood et al.
Tianyuan Lu et al.
Background: There is a pressing need for novel drug targets for psychiatric disorders. Circulating proteins are potential candidates because they are relatively easy to measure and modulate and play important roles in sig...
A Neurobiological Profile Underlying Comorbidity Load and Prospective Increases in Dysphoria in a Focal Fear Sample [0.03%]
基于焦点恐惧样本的共病负荷及未来忧郁症增加的神经生物学特征
Elizabeth A Bauer,Kayla A Wilson,K Luan Phan et al.
Elizabeth A Bauer et al.
Background: Knowledge of the neural mechanisms underlying increased disease burden in anxiety disorders that is unaccounted for by individual categorical diagnoses could lead to improved clinical care. Here, we tested the...
Phenome-wide Association Analysis of Substance Use Disorders in a Deeply Phenotyped Sample [0.03%]
物质使用障碍的全表型组关联分析：基于深度表型样本的研究
Rachel L Kember,Emily E Hartwell,Heng Xu et al.
Rachel L Kember et al.
Background: Substance use disorders (SUDs) are associated with a variety of co-occurring psychiatric disorders and other SUDs, which partly reflects genetic pleiotropy. Polygenic risk scores (PRSs) and phenome-wide associ...
Effective Connectivity of Functionally Anticorrelated Networks Under Lysergic Acid Diethylamide [0.03%]
氯胺酮作用下功能反相关网络的有效连接性
Devon Stoliker,Leonardo Novelli,Franz X Vollenweider et al.
Devon Stoliker et al.
Background: Classic psychedelic-induced ego dissolution involves a shift in the sense of self and a blurring of the boundary between the self and the world. A similar phenomenon is identified in psychopathology and is ass...
Lysergic Acid Diethylamide-Assisted Therapy in Patients With Anxiety With and Without a Life-Threatening Illness: A Randomized, Double-Blind, Placebo-Controlled Phase II Study [0.03%]
静脉注射裸质酸二乙胺辅助治疗焦虑症：一项针对生命垂危和非生命垂危患者的随机双盲对照二期临床试验
Friederike Holze,Peter Gasser,Felix Müller et al.
Friederike Holze et al.
Background: This study aimed to investigate the efficacy and safety of lysergic acid diethylamide (LSD)-assisted therapy in patients who experienced anxiety with or without association with a life-threatening illness. ...
Nisha Raj
Nisha Raj
Published Erratum
Biological psychiatry. 2022 Nov 15;92(10):827. DOI:10.1016/j.biopsych.2022.08.005 2022
Daniel R Weinberger
Daniel R Weinberger