The Relationship of Attention-Deficit/Hyperactivity Disorder With Posttraumatic Stress Disorder: A Two-Sample Mendelian Randomization and Population-Based Sibling Comparison Study [0.03%]
注意缺陷多动障碍与创伤后应激障碍的关系：一项两样本孟德尔随机化和基于人群的同胞对比研究
Frank R Wendt,Miguel Garcia-Argibay,Brenda Cabrera-Mendoza et al.
Frank R Wendt et al.
Background: Attention-deficit/hyperactivity disorder (ADHD) and posttraumatic stress disorder (PTSD) are associated, but it is unclear if this is a causal relationship or confounding. We used genetic analyses and sibling ...
Medial Frontal Cortex GABA Concentrations in Psychosis Spectrum and Mood Disorders: A Meta-analysis of Proton Magnetic Resonance Spectroscopy Studies [0.03%]
精神分裂症谱系和心境障碍的内侧前额叶皮层的γ-氨基丁酸浓度：基于氢磁共振波普研究的元分析
Molly Simmonite,Clara J Steeby,Stephan F Taylor
Molly Simmonite
Background: Abnormalities of GABAergic (gamma-aminobutyric acidergic) systems may play a role in schizophrenia and mood disorders. Magnetic resonance spectroscopy allows for noninvasive in vivo quantification of GABA; how...
Histone Methyltransferase SETDB1 Regulates the Development of Cortical Htr3a-Positive Interneurons and Mood Behaviors [0.03%]
组蛋白甲基转移酶SETDB1调控皮层Htr3a阳性中间神经元的发育及情绪行为
Jiaqi Li,Shenghui Zheng,Yuhao Dong et al.
Jiaqi Li et al.
Background: GABAergic (gamma-aminobutyric acidergic) interneurons (INs) are highly heterogeneous, and Htr3a labels a subpopulation of cortical INs originating from the embryonic caudal ganglionic eminence. SETDB1 is one o...
Mindfulness Training Changes Brain Dynamics During Depressive Rumination: A Randomized Controlled Trial [0.03%]
正念训练改变抑郁症沉思时的脑动力学：一项随机对照试验
Anne Maj van der Velden,Jacqueline Scholl,Else-Marie Elmholdt et al.
Anne Maj van der Velden et al.
Background: Depression is a leading cause of disability worldwide and its prevalence is on the rise. One of the most debilitating aspects of depression is the dominance and persistence of depressive rumination, a state of...
Randomized Controlled Trial
Biological psychiatry. 2023 Feb 1;93(3):233-242. DOI:10.1016/j.biopsych.2022.06.038 2023
Orexin Reserve: A Mechanistic Framework for the Role of Orexins (Hypocretins) in Addiction [0.03%]
食欲肽储备：食欲肽（下丘脑肽）在成瘾中作用的机制框架
Morgan H James,Gary Aston-Jones
Morgan H James
In 2014, we proposed that orexin signaling transformed motivationally relevant states into adaptive behavior directed toward exploiting an opportunity or managing a threat, a process we referred to as motivational activation. Advancements i...
Iris M Balodis
Iris M Balodis
Peter T Morgan
Peter T Morgan
Leveraging Machine Learning for Gaining Neurobiological and Nosological Insights in Psychiatric Research [0.03%]
利用机器学习在精神病学研究中获得神经生物学和疾病分类的见解
Ji Chen,Kaustubh R Patil,B T Thomas Yeo et al.
Ji Chen et al.
Much attention is currently devoted to developing diagnostic classifiers for mental disorders. Complementing these efforts, we highlight the potential of machine learning to gain biological insights into the psychopathology and nosology of ...