Selective Amygdala Hypoactivity to Fear in Boys With Persistent Conduct Problems After Parent Training [0.03%]
父母训练后持续存在行为问题的男孩对恐惧的选择性杏仁体低活性反应
Arjun Sethi,Suzanne O&#x;Brien,James Blair et al.
Arjun Sethi et al.
Background: Parenting interventions reduce antisocial behavior (ASB) in some children with conduct problems (CPs), but not others. Understanding the neural basis for this disparity is important because persistent ASB is a...
Ignacio Saez,Xiaosi Gu
Ignacio Saez
Computational psychiatry, a relatively new yet prolific field that aims to understand psychiatric disorders with formal theories about the brain, has seen tremendous growth in the past decade. Despite initial excitement, actual progress mad...
Social Attention: Developmental Foundations and Relevance for Autism Spectrum Disorder [0.03%]
社会注意力：发展基础及自闭症谱系障碍的相关性
Terje Falck-Ytter,Johan Lundin Kleberg,Ana Maria Portugal et al.
Terje Falck-Ytter et al.
The use of the term "social attention" (SA) in the cognitive neuroscience and developmental psychopathology literature has increased exponentially in recent years, in part motivated by the aim to understand the early development of autism s...
Emulating a Target Trial of Dynamic Treatment Strategies for Major Depressive Disorder Using Data From the STAR∗D Randomized Trial [0.03%]
使用STAR*D随机试验的数据模拟重度抑郁症的动态治疗策略的目标试验
Alejandro G Szmulewicz,Kerollos N Wanis,Roy H Perlis et al.
Alejandro G Szmulewicz et al.
Background: Clinical guidelines recommend adding a second drug for patients with major depressive disorder who have a partial response and switching antidepressants for those who show no response or intolerance. This guid...
Randomized Controlled Trial
Biological psychiatry. 2023 Jun 15;93(12):1127-1136. DOI:10.1016/j.biopsych.2022.09.028 2023
Brain Serotonin Release Is Reduced in Patients With Depression: A [11C]Cimbi-36 Positron Emission Tomography Study With a d-Amphetamine Challenge [0.03%]
抑郁患者脑内5羟色胺释放减少：一项采用d-苯丙胺激发的[11C]Cimbi-36正电子发射断层显像研究
David Erritzoe,Beata R Godlewska,Gaia Rizzo et al.
David Erritzoe et al.
Background: The serotonin hypothesis of depression proposes that diminished serotonergic (5-HT) neurotransmission is causal in the pathophysiology of the disorder. Although the hypothesis is over 50 years old, there is no...
Jason J Radley,James P Herman
Jason J Radley
The experience of prolonged stress changes how individuals interact with their environment and process interoceptive cues, with the end goal of optimizing survival and well-being in the face of a now-hostile world. The chronic stress respon...
A Mega-analytic Study of White Matter Microstructural Differences Across 5 Cohorts of Youths With Attention-Deficit/Hyperactivity Disorder [0.03%]
跨越注意力缺陷/多动障碍青年受试者的五个队列的白质微结构差异的大规模分析研究
Gustavo Sudre,Luke Norman,Marine Bouyssi-Kobar et al.
Gustavo Sudre et al.
Background: While attention-deficit/hyperactivity disorder (ADHD) has been associated with differences in the structural connections formed by the brain's white matter tracts, studies of such differences have yielded inco...
Petra E Vértes
Petra E Vértes
Over the last decade, the organization of brain networks at both micro- and macroscales has become a key focus of neuroscientific inquiry. This has revealed fundamental features of brain network organization-small-worldness, modularity, hea...
Early Social Adversity, Altered Brain Functional Connectivity, and Mental Health [0.03%]
早期社会逆境、改变的脑功能连接和心理健康
Nathalie E Holz,Oksana Berhe,Seda Sacu et al.
Nathalie E Holz et al.
Early adverse environmental exposures during brain development are widespread risk factors for the onset of severe mental disorders and strong and consistent predictors of stress-related mental and physical illness and reduced life expectan...
Excitatory Dysfunction Drives Network and Calcium Handling Deficits in 16p11.2 Duplication Schizophrenia Induced Pluripotent Stem Cell-Derived Neurons [0.03%]
兴奋性功能障碍驱动16p11.2复制 schizophrenia 诱导多能干细胞衍生神经元中的网络和钙处理缺陷
Euan Parnell,Lorenza Culotta,Marc P Forrest et al.
Euan Parnell et al.
Background: Schizophrenia (SCZ) is a debilitating psychiatric disorder with a large genetic contribution; however, its neurodevelopmental substrates remain largely unknown. Modeling pathogenic processes in SCZ using human...