Lu Wang,Charlotte Owusu-Hammond,David Sievert et al.
Lu Wang et al.
The past decade has seen an explosion in the identification of genetic causes of neurodevelopmental disorders, including Mendelian, de novo, and somatic factors. These discoveries provide opportunities to understand cellular and molecular m...
Prioritization of Drug Targets for Neurodegenerative Diseases by Integrating Genetic and Proteomic Data From Brain and Blood [0.03%]
通过整合来自大脑和血液的遗传和蛋白质组数据优先确定神经退行性疾病的药物靶点
Yi-Jun Ge,Ya-Nan Ou,Yue-Ting Deng et al.
Yi-Jun Ge et al.
Background: Neurodegenerative diseases are among the most prevalent and devastating neurological disorders, with few effective prevention and treatment strategies. We aimed to integrate genetic and proteomic data to prior...
Present and Future Modeling of Human Psychiatric Connectopathies With Brain Organoids [0.03%]
人脑类器官中精神疾病连接障碍的现状和未来模拟研究
Jean-Paul Urenda,Ashley Del Dosso,Marcella Birtele et al.
Jean-Paul Urenda et al.
Brain organoids derived from human pluripotent stem cells are emerging as a powerful tool to model cellular aspects of neuropsychiatric disorders, including alterations in cell proliferation, differentiation, migration, and lineage trajecto...
Machine Learning and Prediction in Fetal, Infant, and Toddler Neuroimaging: A Review and Primer [0.03%]
机器学习与胎儿、婴儿和幼儿神经影像的预测：综述及入门介绍
Dustin Scheinost,Angeliki Pollatou,Alexander J Dufford et al.
Dustin Scheinost et al.
Predictive models in neuroimaging are increasingly designed with the intent to improve risk stratification and support interventional efforts in psychiatry. Many of these models have been developed in samples of children school-aged or olde...
Youbin Kim,Hyejin Park,Youngwon Kim et al.
Youbin Kim et al.
Background: In tauopathies, brain regions with tau accumulation strongly correlate with clinical symptoms, and spreading of misfolded tau along neural network leads to disease progression. However, the underlying mechanis...
How Discrimination Gets Under the Skin: Biological Determinants of Discrimination Associated With Dysregulation of the Brain-Gut Microbiome System and Psychological Symptoms [0.03%]
歧视如何影响人的生理：与大脑-肠道微生物系统失调和心理症状相关的生物学决定因素
Tien S Dong,Gilbert C Gee,Hiram Beltran-Sanchez et al.
Tien S Dong et al.
Background: Discrimination is associated with negative health outcomes as mediated in part by chronic stress, but a full understanding of the biological pathways is lacking. Here we investigate the effects of discriminati...
Maternal Mental Health and Offspring Brain Development: An Umbrella Review of Prenatal Interventions [0.03%]
孕期心理健康与子代脑发育：对产前干预措施的伞式综述
Claudia Lugo-Candelas,Ardesheer Talati,Caila Glickman et al.
Claudia Lugo-Candelas et al.
The idea that risk for psychiatric disorders may be transmitted intergenerationally via prenatal programming places interest in the prenatal period as a critical moment during which intervention efforts may have a strong impact, yet studies...
Lessons Learned From Parsing Genetic Risk for Schizophrenia Into Biological Pathways [0.03%]
解析精神分裂症遗传风险进入生物途径的教训
Giulio Pergola,Nora Penzel,Leonardo Sportelli et al.
Giulio Pergola et al.
The clinically heterogeneous presentation of schizophrenia is compounded by the heterogeneity of risk factors and neurobiological correlates of the disorder. Genome-wide association studies in schizophrenia have uncovered a remarkably high ...
Immersion Fixation and Staining of Multicubic Millimeter Volumes for Electron Microscopy-Based Connectomics of Human Brain Biopsies [0.03%]
用于人类脑活检的电子显微镜连接组学的多立方毫米体积浸入固定和染色法
Neha Karlupia,Richard L Schalek,Yuelong Wu et al.
Neha Karlupia et al.
Connectomics allows mapping of cells and their circuits at the nanometer scale in volumes of approximately 1 mm3. Given that the human cerebral cortex can be 3 mm in thickness, larger volumes are required. Larger-volume circuit reconstructi...
What Have Organoids and Assembloids Taught Us About the Pathophysiology of Neuropsychiatric Disorders? [0.03%]
类器官和组装体教给我们关于神经精神疾病病理生理学的哪些知识？
Rebecca J Levy,Sergiu P Paşca
Rebecca J Levy
Neuropsychiatric research has been impeded by limited access to human brain tissue, especially from early stages of neurodevelopment when the pathophysiology of many childhood-onset disorders is initiated. Neural organoids are 3-dimensional...