A Phenome-wide Association and Mendelian Randomization Study for Alzheimer's Disease: A Prospective Cohort Study of 502,493 Participants From the UK Biobank [0.03%]
英国生物样本库中502493名受试者的前瞻性队列研究：阿尔茨海默病的泛表型关联和孟德尔随机化研究
Shi-Dong Chen,Wei Zhang,Yu-Zhu Li et al.
Shi-Dong Chen et al.
Background: Considerable uncertainty remains regarding associations of multiple risk factors with Alzheimer's disease (AD). We aimed to systematically screen and validate a wide range of potential risk factors for AD. ...
Computational Mechanisms of Addiction and Anxiety: A Developmental Perspective [0.03%]
从发展视角看上瘾和焦虑的计算机制
Noam Goldway,Eran Eldar,Gal Shoval et al.
Noam Goldway et al.
A central goal of computational psychiatry is to identify systematic relationships between transdiagnostic dimensions of psychiatric symptomatology and the latent learning and decision-making computations that inform individuals' thoughts, ...
Differences in Quantification of the Metabotropic Glutamate Receptor 5 Across Bipolar Disorder and Major Depressive Disorder [0.03%]
metabotropic谷氨酸受体5在双相情感障碍和抑郁症患者中定量的差异
Sophie E Holmes,Ruth H Asch,Margaret T Davis et al.
Sophie E Holmes et al.
Background: Understanding the neurobiology underlying bipolar disorder (BD) versus major depressive disorder (MDD) is crucial for accurate diagnosis and for driving the discovery of novel treatments. A promising target is...
Excessive Protein Accumulation and Impaired Autophagy in the Hippocampus of Angelman Syndrome Modeled in Mice [0.03%]
天使人综合症小鼠模型海马区蛋白质过度聚集及自噬异常
Francesca Aria,Kiran Pandey,Cristina M Alberini
Francesca Aria
Background: Angelman syndrome (AS), a neurodevelopmental disorder caused by abnormalities of the 15q11.2-q13.1 chromosome region, is characterized by impairment of cognitive and motor functions, sleep problems, and seizur...
No Clear Evidence of Reduced Brain Serotonin Release Capacity in Patients With Depression [0.03%]
抑郁症患者脑内血清素释放能力减低的证据不足
Michael P Hengartner,Martin Plöderl
Michael P Hengartner
Reply to: No Clear Evidence of Reduced Brain Serotonin Release Capacity in Patients With Depression [0.03%]
关于抑郁症患者脑内5-HT功能受损的否定意见及讨论回复
Eugenii A Rabiner,Claudio Agnorelli,Oliver Howes et al.
Eugenii A Rabiner et al.
The Cutting Edge of Epigenetic Clocks: In Search of Mechanisms Linking Aging and Mental Health [0.03%]
表观遗传钟的前沿：探寻衰老与精神健康之间的联系机制
Zachary M Harvanek,Marco P Boks,Christiaan H Vinkers et al.
Zachary M Harvanek et al.
Individuals with psychiatric disorders are at increased risk of age-related diseases and early mortality. Recent studies demonstrate that this link between mental health and aging is reflected in epigenetic clocks, aging biomarkers based on...
Impact of Copy Number Variants and Polygenic Risk Scores on Psychopathology in the UK Biobank [0.03%]
英国生物样本库中拷贝数变异和多基因风险评分对心理病理学的影响
Josephine Mollon,Laura M Schultz,Guillaume Huguet et al.
Josephine Mollon et al.
Background: Our understanding of the impact of copy number variants (CNVs) on psychopathology and their joint influence with polygenic risk scores (PRSs) remains limited. ...
Metabolomic Investigation of Major Depressive Disorder Identifies a Potentially Causal Association With Polyunsaturated Fatty Acids [0.03%]
代谢组学调查发现重大抑郁障碍与多不饱和脂肪酸之间存在潜在的因果关系
Eleanor Davyson,Xueyi Shen,Danni A Gadd et al.
Eleanor Davyson et al.
Background: Metabolic differences have been reported between individuals with and without major depressive disorder (MDD), but their consistency and causal relevance have been unclear. ...
Development and Application of Brain Region-Specific Organoids for Investigating Psychiatric Disorders [0.03%]
用于研究精神疾病的特定脑区器官样细胞系的建立与应用
Zhijian Zhang,Xin Wang,Sean Park et al.
Zhijian Zhang et al.
Human society has been burdened by psychiatric disorders throughout the course of its history. The emergence and rapid advances of human brain organoid technology provide unprecedented opportunities for investigation of potential disease me...