RNA in plasma extracellular vesicles of adolescent rhesus macaques reveal immune, bioenergetic and microbial imprints of early life adversity - an exploratory analysis [0.03%]
青少年恒河猴血浆细胞外囊泡中的RNA揭示了早期生活逆境的免疫、生物能量和微生物印记-一项探索性分析
Laura Korobkova,Matthew E Thornton,Matthew A Collin et al.
Laura Korobkova et al.
Background: Exposure to early life adversity (ELA), including childhood maltreatment, is one of the most significant risk factors for the emergence of psychosomatic disorders in adolescence and adulthood. Most investigati...
Charles F Zorumski,Steven Mennerick
Charles F Zorumski
Biomarkers for the Diagnosis of Perinatal Mood and Anxiety Disorders: Existing Landscapes and Emerging Frontiers [0.03%]
围产期情绪和焦虑障碍诊断的生物标志物：现有的研究领域和新兴前沿方向
Michaela Kiel,Stacey Pawlak,Sarah van Dijk et al.
Michaela Kiel et al.
Perinatal mood and anxiety disorders (PMADs) are a spectrum of mental health conditions that are the most common pregnancy-related complications in the United States. Despite great strides in developing appropriate pharmacological and psych...
Edge-centric Brain Connectome Representations Reveal Increased Brain Functional Diversity of Reward Circuit in Patients with Major Depressive Disorder [0.03%]
基于边缘的大脑连接组表示揭示了抑郁症患者奖赏回路大脑功能多样性增加
Kun Qin,Chunqi Ai,Pengyu Zhu et al.
Kun Qin et al.
Background: Major depressive disorder (MDD) has been increasingly understood as a disorder of network-level functional dysconnectivity. However, previous brain connectome studies have primarily relied on node-centric appr...
CUT&RUN as a Powerful Tool for Chromatin Profiling: a Focus on Neuropsychiatric Disorders [0.03%]
染色质分析的强力工具： CUT&RUN技术在神经精神疾病中的应用
Leanne M Holt,Earnest P Chen,Brandon W Hughes et al.
Leanne M Holt et al.
Proper regulation of gene expression involves a complex array of crosstalk between chromatin remodeling, histone and DNA modifications, and transcription factors. Dysregulation of these processes is implicated in a wide range of neuropsychi...
Leila Tarokh,Carolina Guiterrez-Herrera
Leila Tarokh
Adolescence marks a critical developmental period characterized by dramatic brain maturation and heightened vulnerability to psychiatric disorders. This review underscores the pivotal role of sleep in adolescent development and its bidirect...
Jonathan W Kanen,Martijn Figee,Rita Z Goldstein et al.
Jonathan W Kanen et al.