Laminar-Specific Alterations in Calbindin-Positive Boutons in the Prefrontal Cortex of Subjects With Schizophrenia [0.03%]
精神分裂症患者前额叶皮层钙结合蛋白阳性突触末端的特异变化
Kenneth N Fish,Brad R Rocco,James D Wilson et al.
Kenneth N Fish et al.
Background: Cognitive deficits in schizophrenia are associated with altered GABA (gamma-aminobutyric acid) neurotransmission in the prefrontal cortex (PFC). GABA neurotransmission requires GABA synthesis by 2 isoforms of ...
Association Between Fatty Acid Amide Hydrolase and Alcohol Response Phenotypes: A Positron Emission Tomography Imaging Study With [11C]CURB in Heavy-Drinking Youth [0.03%]
酰胺水解酶与酒精反应表型之间的关系：在重度饮酒青年中进行的[curb-11c]正电子发射断层成像研究
Laura M Best,Christian S Hendershot,Jennifer F Buckman et al.
Laura M Best et al.
Background: Reductions in fatty acid amide hydrolase (FAAH), the catabolic enzyme for the endocannabinoid anandamide, may play a role in drinking behavior and risk for alcohol use disorder. We tested the hypotheses that l...
Dual-Target Deep Brain Stimulation for Obsessive-Compulsive Disorder and Tourette Syndrome [0.03%]
双靶点深部脑刺激治疗强迫症和抽动秽语综合征
Ricardo A Najera,Nicole Provenza,Huy Dang et al.
Ricardo A Najera et al.
NMDA Receptor-Dependent Synaptic Potentiation via APPL1 Signaling Is Required for the Accessibility of a Prefrontal Neuronal Assembly in Retrieving Fear Extinction [0.03%]
APPL1信号依赖于NMDA受体的突触促进作用是用于检索恐惧消退的一个前额叶神经元组件的访问所必需的
Shu-Shan Hua,Jin-Jun Ding,Tian-Cheng Sun et al.
Shu-Shan Hua et al.
Background: The ventromedial prefrontal cortex has been viewed as a locus for storage and recall of extinction memory. However, the synaptic and cellular mechanisms underlying these processes remain elusive. ...
Current Approaches in Computational Psychiatry for the Data-Driven Identification of Brain-Based Subtypes [0.03%]
计算精神病学中基于数据的精神病亚型大脑基础的当前研究方法
Leyla R Brucar,Eric Feczko,Damien A Fair et al.
Leyla R Brucar et al.
The ability of our current psychiatric nosology to accurately delineate clinical populations and inform effective treatment plans has reached a critical point with only moderately successful interventions and high relapse rates. These chall...
Mu Opioid Receptor Activation Mediates (S)-ketamine Reinforcement in Rats: Implications for Abuse Liability [0.03%]
活化μ阿片受体介导大鼠中的(S)-氯胺酮的滥用潜力：对药物滥用潜在性的启示
Marjorie R Levinstein,Meghan L Carlton,Tommaso Di Ianni et al.
Marjorie R Levinstein et al.
Background: (S)-ketamine is an NMDA receptor antagonist, but it also binds to and activates mu opioid receptors (MORs) and kappa opioid receptors in vitro. However, the extent to which these receptors contribute to (S)-ke...
Abnormally Enhanced Midfrontal Theta Activity During Response Monitoring in Youths With Obsessive-Compulsive Disorder [0.03%]
obsessive-compulsive disorder患者反应监控过程中异常增强的中前额θ活动
Takakuni Suzuki,Pan Gu,Tyler B Grove et al.
Takakuni Suzuki et al.
Background: Response monitoring, as reflected in electroencephalogram recordings after commission of errors, has been consistently shown to be abnormally enhanced in individuals with obsessive-compulsive disorder (OCD). T...
Oxytocin Reduces Sensitized Stress-Induced Alcohol Relapse in a Model of Posttraumatic Stress Disorder and Alcohol Use Disorder Comorbidity [0.03%]
血管缩素能减少应激诱导的创伤后压力障碍和酒精使用障碍共病模型中的条件化酒精反复发作
Howard C Becker,Marcelo F Lopez,Courtney E King et al.
Howard C Becker et al.
Background: There is high comorbidity of posttraumatic stress disorder (PTSD) and alcohol use disorder with few effective treatment options. Animal models of PTSD have shown increases in alcohol drinking, but effects of s...
Spinophilin Limits Metabotropic Glutamate Receptor 5 Scaffolding to the Postsynaptic Density and Cell Type Specifically Mediates Excessive Grooming [0.03%]
自旋菲林限制 metabotropic 谷氨酸受体 5 组织到突触后致密物质并特异性介导过度梳理行为
Cameron W Morris,Darryl S Watkins,Nikhil R Shah et al.
Cameron W Morris et al.
Background: Grooming dysfunction is a hallmark of the obsessive-compulsive spectrum disorder trichotillomania. Numerous preclinical studies have utilized SAPAP3-deficient mice for understanding the neurobiology of repetit...
The Addiction-Susceptibility TaqIA/Ankk1 Controls Reward and Metabolism Through D2 Receptor-Expressing Neurons [0.03%]
成瘾易感基因TaqIA/Ankk1通过D2受体表达神经元控制奖赏和代谢功能
Enrica Montalban,Roman Walle,Julien Castel et al.
Enrica Montalban et al.
Background: A large body of evidence highlights the importance of genetic variants in the development of psychiatric and metabolic conditions. Among these, the TaqIA polymorphism is one of the most commonly studied in psy...