Cell Type-Specific Whole-Genome Landscape of ΔFOSB Binding in the Nucleus Accumbens After Chronic Cocaine Exposure [0.03%]
慢性可卡因暴露后ΔFOSB在不同细胞类型中的全基因组结合图谱及在伏隔核中的作用
Szu-Ying Yeh,Molly Estill,Casey K Lardner et al.
Szu-Ying Yeh et al.
Background: The ability of neurons to respond to external stimuli involves adaptations of gene expression. Induction of the transcription factor ΔFOSB in the nucleus accumbens, a key brain reward region, is important for...
Imaging Nociceptin Opioid Peptide Receptors in Alcohol Use Disorder With [11C]NOP-1A and Positron Emission Tomography: Findings From a Second Cohort [0.03%]
使用[NOP-1A和正电子发射断层扫描成像酒精使用障碍中的伤害性感受肽阿片受体：来自第二队列的结果
Savannah Tollefson,Clara Stoughton,Michael L Himes et al.
Savannah Tollefson et al.
Background: Nociceptin, which binds to the nociceptin opioid peptide receptor (NOP), regulates stress and reward in addiction. In a previous [11C]NOP-1A positron emission tomography (PET) study, we found no differences in...
Amanda C Wylie,Sarah J Short
Amanda C Wylie
Early life represents the most rapid and foundational period of brain development and a time of vulnerability to environmental insults. Evidence indicates that greater exposure to ubiquitous toxicants like fine particulate matter (PM2.5), m...
Recovery From Psychotic Disorder: A Surgical Case With Lhermitte-Duclos Disease [0.03%]
以Lhermitte-Duclos病变为背景的精神分裂症患者的康复——一例手术治疗报告
Jiahe Guo,Junjie Gong,Huijie Wei et al.
Jiahe Guo et al.
Dorsal Dentate Gyrus, a Key Regulator for Mood and Psychiatric Disorders [0.03%]
齿状回背侧部，情绪和精神障碍的关键调节区域
Dong Sun,Lin Mei,Wen-Cheng Xiong
Dong Sun
The dentate gyrus, a "gate" that controls the flow of information into the hippocampus, is critical for learning, memory, spatial navigation, and mood regulation. Several lines of evidence have demonstrated that deficits in dentate granule ...
Linda L Carpenter,Noah S Philip
Linda L Carpenter
Julia N Riddle,Bernice Yau,Erica Baller et al.
Julia N Riddle et al.
Neural Organoids and the Quest to Understand and Treat Psychiatric Disease [0.03%]
脑器官芯片与理解并治疗精神疾病的研究之旅
Paola Arlotta,Fred H Gage
Paola Arlotta
Prenatal Stress and the Developing Brain: Postnatal Environments Promoting Resilience [0.03%]
孕期压力与发育中的大脑：促进恢复力的产后环境
Saara Nolvi,Emily C Merz,Eeva-Leena Kataja et al.
Saara Nolvi et al.
Heightened maternal stress during pregnancy is associated with atypical brain development and an elevated risk for psychopathology in offspring. Supportive environments during early postnatal life may promote brain development and reverse a...
Genome-wide Survival Study Identifies PARL as a Novel Locus for Clinical Progression and Neurodegeneration in Alzheimer's Disease [0.03%]
全基因组生存研究鉴定出PARL是阿尔茨海默病临床进展和神经退行性病变的新易感位点
Shi-Dong Chen,Wei Zhang,Yi-Wei Feng et al.
Shi-Dong Chen et al.
Background: Variability exists in the trajectories of Alzheimer's disease (AD). We aimed to identify genetic modulators of clinical progression in AD. Met...