Emerging Topics in Computational Psychiatric Research: Clarity Through Complexity? [0.03%]
计算精神病学研究中的新兴课题：复杂性带来的清晰度？
Sarah W Yip,Anna B Konova
Sarah W Yip
Ancestral, Pregnancy, and Negative Early-Life Risks Shape Children's Brain (Dis)similarity to Schizophrenia [0.03%]
遗传、妊娠及早期不良经历风险因素塑造儿童精神分裂症脑网络模板的镜像或相反模式
Peter Kochunov,Yizhou Ma,Kathryn S Hatch et al.
Peter Kochunov et al.
Background: Familial, obstetric, and early-life environmental risks for schizophrenia spectrum disorder (SSD) alter normal cerebral development, leading to the formation of characteristic brain deficit patterns prior to o...
Baby Brains at Work: How Task-Based Functional Magnetic Resonance Imaging Can Illuminate the Early Emergence of Psychiatric Risk [0.03%]
婴儿大脑的工作原理：基于任务的功能磁共振成像如何揭示精神疾病风险的早期出现
Ashley N Nielsen,Alice M Graham,Chad M Sylvester
Ashley N Nielsen
Psychiatric disorders are complex, often emerging from multiple atypical processes within specified domains over the course of development. Characterizing the development of the neural circuits supporting these domains may help break down t...
Genetic Influences on the Developing Young Brain and Risk for Neuropsychiatric Disorders [0.03%]
遗传因素对发育中年轻大脑的影响及神经精神疾病的风险
Ann M Alex,Claudia Buss,Elysia Poggi Davis et al.
Ann M Alex et al.
Imaging genetics provides an opportunity to discern associations between genetic variants and brain imaging phenotypes. Historically, the field has focused on adults and adolescents; very few imaging genetics studies have focused on brain d...
Arrestin-3 Agonism at Dopamine D3 Receptors Defines a Subclass of Second-Generation Antipsychotics That Promotes Drug Tolerance [0.03%]
通过多巴胺D3受体的 Arrestin-3 激动作用定义了一类促进药物耐受性的第二代抗精神病药亚型
Selin Schamiloglu,Elinor Lewis,Caroline M Keeshen et al.
Selin Schamiloglu et al.
Background: Second-generation antipsychotics (SGAs) are frontline treatments for serious mental illness. Often, individual patients benefit only from some SGAs and not others. The mechanisms underlying this unpredictabili...
A Ventromedial Prefrontal-to-Lateral Entorhinal Cortex Pathway Modulates the Gain of Behavioral Responding During Threat [0.03%]
腹内侧前额叶脑区通过向纹周内侧颞叶的神经投射调控威胁情景下的行为反应强度
Erin Hisey,Alicia Purkey,Yudong Gao et al.
Erin Hisey et al.
Background: The ability to correctly associate cues and contexts with threat is critical for survival, and the inability to do so can result in threat-related disorders such as posttraumatic stress disorder. The prefronta...
Connectome-wide Mega-analysis Reveals Robust Patterns of Atypical Functional Connectivity in Autism [0.03%]
基于连接组的大规模荟萃分析揭示了自闭症中可靠的异常功能连接模式
Iva Ilioska,Marianne Oldehinkel,Alberto Llera et al.
Iva Ilioska et al.
Background: Neuroimaging studies of functional connectivity (FC) in autism have been hampered by small sample sizes and inconsistent findings with regard to whether connectivity is increased or decreased in individuals wi...
Genetic Ablation of GIGYF1, Associated With Autism, Causes Behavioral and Neurodevelopmental Defects in Zebrafish and Mice [0.03%]
与自闭症相关的GIGYF1基因缺失导致斑马鱼和小鼠出现行为及神经发育异常
Zijiao Ding,Guiyang Huang,Tianyun Wang et al.
Zijiao Ding et al.
Background: Autism spectrum disorder is characterized by deficits in social communication and restricted or repetitive behaviors. Due to the extremely high genetic and phenotypic heterogeneity, it is critical to pinpoint ...
Neural Network Functional Interactions Mediate or Suppress White Matter-Emotional Behavior Relationships in Infants [0.03%]
神经网络功能相互作用介导或抑制婴儿白质和情绪行为之间的关系
Layla Banihashemi,Vanessa J Schmithorst,Michele A Bertocci et al.
Layla Banihashemi et al.
Background: Elucidating the neural basis of infant positive emotionality and negative emotionality can identify biomarkers of pathophysiological risk. Our goal was to determine how functional interactions among large-scal...
Rewiring of Prelimbic Inputs to the Nucleus Accumbens Core Underlies Cocaine-Induced Behavioral Sensitization [0.03%]
前肢皮层输入到伏隔核核心神经环路的重构介导可卡因引起的交叉耐受现象
Jaehan Kwon,Hyun Jin Kim,Hyoung-Ro Lee et al.
Jaehan Kwon et al.
Background: Unbalanced activity of medium spiny neurons (MSNs) of the direct and indirect pathways mediates reward-related behaviors induced by addictive drugs. Prelimbic (PL) input to MSNs in the nucleus accumbens core (...