Sex differences in brain cell-type specific chromatin accessibility in schizophrenia [0.03%]
精神分裂症中与性别相关的特定脑细胞类型染色质可及性差异研究
Yixuan Ma,Kiran Girdhar,Gabriel E Hoffman et al.
Yixuan Ma et al.
Background: Our understanding of the sex-specific role of the non-coding genome in serious mental illnesses, particularly schizophrenia (SCZ), remains largely incomplete. ...
A framework for advancing mechanistic neuro-behavioral biomarkers in psychiatry [0.03%]
精神病学中推进机制神经行为生物标志物的框架
Kangjoo Lee,Jie Lisa Ji,Markus Helmer et al.
Kangjoo Lee et al.
Neuropsychiatry has yet to surmount the fundamental challenge of mapping behavioral pathology to its underlying neural pathology. This gap limits the development of treatments for specific circuit pathologies, despite the great potential of...
Paul C Fletcher,Trevor W Robbins
Paul C Fletcher
Thomas A Pollak
Thomas A Pollak
A tale of two receptors: simultaneous targeting of NMDARs and 5-HT4Rs exerts additional effects against stress [0.03%]
双重受体的传奇：NMDAR和5-HT4R的协同靶向作用对压力产生附加效应
Briana K Chen,Michelle Jin,Gergely F Turi et al.
Briana K Chen et al.
Background: Serotonin (5-HT) receptors and N-methyl-D-aspartate receptors (NMDARs) have been implicated in the pathophysiology of depression and anxiety disorders. Here, we evaluated whether targeting both receptors throu...
Task and resting state fMRI modelling of brain-behavior relationships in developmental cohorts [0.03%]
发育队列中任务和静息态fMRI对脑-行为关系的建模研究
Lucina Q Uddin,Hugh Garavan
Lucina Q Uddin
Functional magnetic resonance imaging (fMRI) data are often used to inform individual differences in cognitive, behavioral, and psychiatric phenotypes. These so-called "brain-behavior" association studies come in many flavors and are increa...
Clinical Genetic Testing in Schizophrenia: A Systematic Review and Meta-Analysis [0.03%]
系统综述与元分析在精神分裂症中的临床基因检测
Harman Singh Brah,Nimrat Sran,Sanjana Sanghani et al.
Harman Singh Brah et al.
Background: Genetic testing may provide important diagnostic information for individuals with schizophrenia, but the frequency with which clinically significant variants are identified across different testing approaches ...
Systematic review and mega-analysis of the peripheral blood transcriptome in depression implicates dysregulation of lymphoid cells and histones [0.03%]
抑郁患者外周血转录组的系统评价与荟萃分析提示淋巴细胞和组蛋白表达异常
Chaitanya Erady,Richard Bethlehem,Edward Bullmore et al.
Chaitanya Erady et al.
Background: Depression has been associated with transcriptomic changes in peripheral blood. However, the contribution of specific immune cell subsets or pathways remains unclear, and findings have been variable across pre...
Genetic susceptibility to neurodevelopmental conditions associates with neonatal DNA methylation patterns in the general population: an individual participant data meta-analysis [0.03%]
基于个体参与者数据的荟萃分析发现：与神经发育障碍相关的遗传易感性在一般人群中与新生儿DNA甲基化模式相关
Isabel K Schuurmans,Dinka Smajlagic,Vilte Baltramonaityte et al.
Isabel K Schuurmans et al.
Objective: Autism spectrum disorder (ASD), attention-deficit/hyperactivity disorder (ADHD), and schizophrenia (SCZ) are highly heritable and linked to disruptions in fetal neurodevelopment. Epigenetic processes, such as D...