Multivariate Resting-State Functional Connectivity Features Linked to Transdiagnostic Psychopathology in Early Psychosis [0.03%]
多变量静息态功能连接特征与早期精神病跨诊断心理病态的关系
Haley R Wang,Zhen-Qi Liu,Jason S Nomi et al.
Haley R Wang et al.
Background: Early psychosis (EP) is characterized by neurobiological changes, including alterations in resting-state functional connectivity (RSFC). We now understand that symptoms and neural changes may overlap across EP...
From big to small: Emerging methods for enhancing precision psychiatry through transfer learning [0.03%]
从宏观到微观：通过迁移学习提升精准精神病学的新兴方法
Yu-Wei Wang,Avram J Holmes,B T Thomas Yeo et al.
Yu-Wei Wang et al.
Identifying reliable links between individual differences in neurobiological features and differences in symptom profiles or treatment outcomes is a primary goal of precision psychiatry. Within this context, brain-behavior predictive modeli...
Emerging Roles of Chromatin-Associated lncRNAs in 3-Dimensional Chromatin Remodeling and Heterochromatinization: Implications for Major Depressive Disorder [0.03%]
染色质相关长链非编码RNA在三维染色质重塑和异染色体形成中的新兴作用及其对抑郁症的影响
Yogesh Dwivedi,Bhaskar Roy
Yogesh Dwivedi
Major depressive disorder (MDD) is a multifaceted condition that is shaped by an interaction between genetic and environmental factors. Besides the changes at the neuroanatomical level and within brain circuits, how the brain's transcriptom...
Postpartum Psychosis and Bipolar Disorder: Review of Neurobiology and Expert Consensus Statement on classification [0.03%]
产后精神病和双相情感障碍：神经生物学回顾及分类专家共识声明
Veerle Bergink,Schahram Akbarian,Nancy Byatt et al.
Veerle Bergink et al.
Postpartum psychosis (PP) is an acute and severe psychiatric illness with onset within weeks after delivery, and a high risk of suicide and infanticide. Most women with PP experience severe mood symptoms, including mania, mixed episodes, or...
The trace amine-associated receptor 1 regulates presynaptic dopamine function: evidence from preclinical studies and a phase 1b trial in patients with schizophrenia [0.03%]
跟踪胺相关受体1调节突触前多巴胺功能：来自临床前期研究和精神分裂症患者的Ⅱb期试验的证据
Oliver D Howes,Luke J Vano,Alice E Petty et al.
Oliver D Howes et al.
Background: Schizophrenia remains a leading cause of disability globally. Elevated striatal dopamine synthesis capacity is a hallmark of its pathophysiology, but it is unknown whether this can be reduced and whether such ...
Katharina S Lege,Pablo Mallaroni,Sepehr Mortaheb et al.
Katharina S Lege et al.
Background: The impact of acute cannabis exposure on brain function and cognitive performance varies among individuals. Acute effects of cannabis on behavior may be absent or benign in chronic users while occasional users...
KIAA0319 plays a critical role in cortical neuronal maturation and synaptic development through a dyslexia-associated gene network [0.03%]
KIAA0319通过与阅读障碍相关的基因网络在皮层神经元成熟和突触发育中发挥关键作用
Michael J Scandura,Mu Seog Choe,Ferdi Ridvan Kiral et al.
Michael J Scandura et al.
Background: Dyslexia is a common learning disorder characterized by difficulty processing written language despite normal intelligence and adequate educational resources. KIAA0319 is one of nine genes reproducibly associa...
Circulating microRNAs in cord blood to predict attention-deficit/hyperactivity disorder diagnosis [0.03%]
新生儿脐带血中循环microRNA预测注意缺陷多动障碍的研究
Lene B Dypås,Ann-Karin Olsen,Kristine B Gützkow et al.
Lene B Dypås et al.
Background: There are large knowledge gaps in the etiology of attention-deficit/hyperactivity disorder (ADHD) and though it is a prevalent and highly heritable neurodevelopmental disorder, diagnosis can be challenging. We...
Intermittent ketamine and neuromodulation treatment evoke synergistic antidepressant-relevant action [0.03%]
间断性氯胺酮与神经调节治疗产生协同抗抑郁作用
Kyle A Brown,Todd D Gould
Kyle A Brown
Background: Historically, the most effective antidepressant is electroconvulsive therapy (ECT). ECT induces cognitive side effects, and commonly requires numerous treatments over several weeks for robust symptom relief. T...
Reductive Stress and Dysregulated Energy Metabolism in Schizophrenia: Mechanisms and Therapeutic Targets [0.03%]
精神分裂症中的氧化还原压力及代谢紊乱：机制和治疗靶点
Onur Memetoglu,Fei Du,Virginie-Anne Chouinard et al.
Onur Memetoglu et al.
Reductive stress, defined by excessive accumulation of reducing equivalents, such as NADH, disrupts cellular redox balance and is emerging as a detrimental factor in schizophrenia (SZ). It is closely related to the mitochondrial defects com...