Noninvasive Modulation of the Subcallosal Cingulate and Depression With Focused Ultrasonic Waves [0.03%]
聚焦超声波非侵入性调制胼胝体下扣带回和抑郁症的研究
Thomas S Riis,Daniel A Feldman,Sarah S Kwon et al.
Thomas S Riis et al.
Background: Severe forms of depression have been linked to excessive subcallosal cingulate cortex (SCC) activity. Stimulation of the SCC with surgically implanted electrodes can alleviate depression, but current noninvasi...
Refining Criteria for a Neurodevelopmental Subphenotype of Bipolar Disorders: A FondaMental Advanced Centers of Expertise for Bipolar Disorders Study [0.03%]
双相障碍神经发育亚型细化标准：Fondation FondaMenta双相障碍卓越中心研究
Antoine Lefrere,Ophélia Godin,Stéphane Jamain et al.
Antoine Lefrere et al.
Background: Bipolar disorder (BD) is a complex and heterogeneous psychiatric disorder. It has been suggested that neurodevelopmental factors contribute to the etiology of BD, but a specific neurodevelopmental phenotype (N...
Vitamin D's Capacity to Increase Amphetamine-Induced Dopamine Release in Healthy Humans: A Clinical Translational [11C]-PHNO Positron Emission Tomography Study [0.03%]
维生素D增强多巴胺释放的证据：健康人群中安非他明诱导的多巴胺释放的正电子发射断层扫描研究
Patrick D Worhunsky,Marcella M Mignosa,Jean-Dominique Gallezot et al.
Patrick D Worhunsky et al.
Background: Dopaminergic tone and phasic release have transdiagnostic relevance. Preclinical research suggests that the active form of vitamin D, calcitriol, increases subcortical tyrosine hydroxylase, D2/D3 receptors, an...
Association of Allostatic Load With Depression, Anxiety, and Suicide: A Prospective Cohort Study [0.03%]
心理社会压力对精神健康影响的前瞻性队列研究
Yifan Gou,Shiqiang Cheng,Meijuan Kang et al.
Yifan Gou et al.
Background: Allostatic load (AL) is an objective measure of the biological components of chronic stress in clinical practice, which potentially influence depression, anxiety, and suicide. In this study, we investigated th...
Biased Information Routing Through the Basolateral Amygdala, Altered Valence Processing, and Impaired Affective States Associated With Psychiatric Illnesses [0.03%]
偏向性信息通过基底外侧杏仁核的传递，情绪价值处理改变以及与精神疾病相关的情绪障碍
Pantelis Antonoudiou,Eric Teboul,Kenneth A Amaya et al.
Pantelis Antonoudiou et al.
Accumulating evidence supports a role for altered circuit function in impaired valence processing and altered affective states as a core feature of psychiatric illnesses. We review the circuit mechanisms underlying normal valence processing...
Astrogliosis Marker [11C]SL25.1188 After COVID-19 With Ongoing Depressive and Cognitive Symptoms [0.03%]
COVID-19后持续抑郁和认知症状患者的星形胶质细胞标志物[11C]SL25.1188 PET研究
Joeffre Braga,Emily J Y Kuik,Mariel Lepra et al.
Joeffre Braga et al.
Background: After acute COVID-19, 5% of people experience persistent depressive symptoms and reduced cognitive function (COVID-DC). Theoretical models propose that astrogliosis is important in long COVID, but measures pri...
Multiomics Analysis of the Molecular Response to Glucocorticoids: Insights Into Shared Genetic Risk From Psychiatric to Medical Disorders [0.03%]
糖皮质激素分子反应的多组学分析：从精神病到医学疾病的共享遗传风险的新见解
Janine Knauer-Arloth,Anastasiia Hryhorzhevska,Elisabeth B Binder
Janine Knauer-Arloth
Background: Alterations in the effects of glucocorticoids have been implicated in mediating some of the negative health effects associated with chronic stress, including increased risk for psychiatric disorders and cardio...
Genome-Wide Association Study Meta-Analysis of 9619 Cases With Tic Disorders [0.03%]
一项关于抽动障碍的全基因组关联研究 meta 分析（9619 例病例）
Nora I Strom,Matthew W Halvorsen,Jakob Grove et al.
Nora I Strom et al.
Background: Despite the significant personal and societal burden of tic disorders (TDs), treatment outcomes remain modest, necessitating a deeper understanding of their etiology. Family history is the biggest known risk f...
Prophylactic (R,S)-ketamine and (2S,6S)-hydroxynorketamine Decrease Fear Expression by Differentially Modulating Fear Neural Ensembles [0.03%]
预防性使用(R,S) ket胺和(2S,6S)羟基诺酮胺通过差异化调节恐惧神经网络减少恐惧表达
Alessia Mastrodonato,Michelle Jin,Noelle Kee et al.
Alessia Mastrodonato et al.
Background: We previously reported that a single injection of (R,S)-ketamine or its metabolite (2S,6S)-hydroxynorketamine (HNK) prior to stress attenuated learned fear. However, whether these drugs attenuate learned fear ...
Astrocytic CREB in nucleus accumbens promotes susceptibility to chronic stress [0.03%]
星形胶质细胞CREB在伏隔核中促进慢性压力的易感性
Leanne M Holt,Trevonn M Gyles,Eric M Parise et al.
Leanne M Holt et al.
Background: Increasing evidence implicates astrocytes in stress and depression in both rodent models and human Major Depressive Disorder (MDD). Despite this, little is known about the transcriptional responses to stress o...