Convergence on CaMK4: A Key Modulator of Autism-Associated Signaling Pathways in Neurons [0.03%]
CaMK4的汇聚：自闭症相关神经信号通路的关键调节因子
Jacqueline Kaiser,Alana Risteska,Abbey G Muller et al.
Jacqueline Kaiser et al.
Although the precise underlying cause(s) of autism spectrum disorder remain unclear, more than 1000 rare genetic variations are associated with the condition. For many people living with profound autism, this genetic heterogeneity has imped...
Advancing Mental Health Research Through Strategic Integration of Transdiagnostic Dimensions and Genomics [0.03%]
通过战略整合跨诊断维度和基因组学推进心理健康研究
Alysa E Doyle,Carrie E Bearden,Raquel E Gur et al.
Alysa E Doyle et al.
Genome wide studies are yielding a growing catalogue of common and rare variants that confer risk for psychopathology. Yet, despite representing unprecedented progress, emerging data also indicate that the full promise of psychiatric geneti...
Polyconnectomic scoring of functional connectivity patterns across eight neuropsychiatric and three neurodegenerative disorders [0.03%]
基于多连接组学的八大神经精神疾病和三大神经系统退行性疾病的功能连接模式评分
Ilan Libedinsky,Koen Helwegen,Jackson Boonstra et al.
Ilan Libedinsky et al.
Background: Neuropsychiatric and neurodegenerative disorders involve diverse changes in brain functional connectivity. As an alternative to approaches searching for specific mosaic patterns of affected connections and net...
Adenosine 2A Receptors Link Astrocytic Alpha-1 Adrenergic Signaling to Wake-Promoting Dopamine Neurons [0.03%]
腺苷A2A受体连接 astrocyte α-1肾上腺素能信号传导与促醒多巴胺神经元
Nicholas Petersen,Katharine E McCann,Mihaela A Stavarache et al.
Nicholas Petersen et al.
Background: Sleep and arousal disorders are common, but the underlying physiology of wakefulness is not fully understood. The locus coeruleus promotes arousal via alpha-1 adrenergic receptor (α1AR) driven recruitment of ...
Multiomics Reveals Biological Mechanisms Linking Macroscale Structural Covariance Network Dysfunction With Neuropsychiatric Symptoms Across the Alzheimer's Disease Continuum [0.03%]
多组学揭示了宏尺度结构共变网络功能障碍与阿尔茨海默病谱系神经精神症状的生物机制之间的联系
Jiwei Jiang,Kun Zhao,Wenyi Li et al.
Jiwei Jiang et al.
Background: The highly heterogeneity of neuropsychiatric symptoms (NPSs) hinder further exploration of their role in neurobiological mechanisms and Alzheimer's disease (AD). We aimed to delineate NPS patterns based on bra...
Sex-Differential Markers of Psychiatric Risk and Treatment Response Based on Premature Aging of Functional Brain Network Dynamics and Peripheral Physiology [0.03%]
基于功能脑网络动态和外周生理提前衰老的精神疾病风险和治疗反应性别差异标志物
Raluca Petrican,Sidhant Chopra,Christopher Murgatroyd et al.
Raluca Petrican et al.
Background: Aging is a multilevel process of gradual decline that predicts morbidity and mortality. Independent investigations have implicated senescence of brain and peripheral physiology in psychiatric risk, but it is u...
Multimodal Retinal Imaging Findings in Schizophrenia Spectrum Disorders [0.03%]
精神分裂症谱系障碍的多模态视网膜影像学表现
Paulo Lizano,Erik Velez-Perez
Paulo Lizano
Tracing the Trajectory: Polyunsaturated Fatty Acids and Early Adult Psychosis [0.03%]
追踪轨迹：多不饱和脂肪酸与早期成人精神病的关系
Ying He,Linlin Zhao,Xiaogang Chen
Ying He
The Orbitofrontal Cortex to Striatal Cholinergic Interneuron Circuit Controls Cognitive Flexibility Shaping Alcohol-Seeking Behavior [0.03%]
眶额皮层到纹状体胆碱能中间神经元环路控制认知灵活性以塑造寻酒行为
Jiaxin Li,Yao Zhou,Fangyuan Yin et al.
Jiaxin Li et al.
Background: A top-down neuronal circuit from the orbitofrontal cortex (OFC) to the dorsomedial striatum (DMS) appears to be critical for cognitive flexibility. However, how OFC projections to different types of neurons in...