Kristien van der Walt,Dan J Stein,Anthony W Zoghbi
Kristien van der Walt
Since the early 1900s, clinical and epidemiological observations have suggested a link between schizophrenia and the immune system, yet genetic evidence for a pathophysiological connection has remained elusive. Here, we review evidence for ...
Downregulation of Small Conductance Potassium Channels in Cortical Pyramidal Neurons of the Supplementary Motor Cortex Underlies High Cocaine Seeking Behaviors [0.03%]
补充运动皮层中小导管钾通道下调导致高可卡因寻求行为
Donald Huang,Yao-Ying Ma
Donald Huang
Background: Drug relapse remains the primary challenge in treating addiction. Despite substantial research into the neural mechanisms of relapse, particularly in the medial prefrontal cortex associated with drug craving, ...
A Comparison of Positive and Negative Allosteric Modulators of Alpha5-Containing GABAARs in the Treatment of Affective Disease [0.03%]
α5型GABA受体激动剂和拮抗剂在情感障碍疾病治疗中的比较研究
Timothy A Troppoli,Scott M Thompson
Timothy A Troppoli
Major depressive disorder (MDD) is a common psychiatric disease that significantly impairs quality of life and productivity. Unfortunately, standard monoamine-based therapies are marred by poor efficacy. Disruptions in the balance of glutam...
The role of fronto-limbic network in suicide: a descriptive literature review of neuroimaging studies [0.03%]
神经影像学研究中的自杀潜在风险前脑边缘网络的元分析及描述性文献综述
Yuhao Shen,Jiajia Zhu,Yongqiang Yu
Yuhao Shen
Suicide is a complex public health issue characterized by impairments in emotion regulation and cognitive control. Identifying the brain substrates of suicide is critical for developing targeted and effective prevention strategies. Given th...
Published Erratum
Biological psychiatry. 2025 Nov 10:S0006-3223(25)01570-7. DOI:10.1016/j.biopsych.2025.10.021 2025
Mapping DNA methylation signatures to identify epigenetic variation across subcortical regions of the human PTSD brain [0.03%]
绘制DNA甲基化图谱以识别PTSD患者大脑皮层下区域表观遗传变异
Hongyu Li,Yujing Liu,Yiming Shi et al.
Hongyu Li et al.
Background: Post-traumatic stress disorder is a mental disorder that may occur in the aftermath of severe psychological trauma. Epigenetic changes in the brain may play a critical role in understanding the neurobiology of...
Brittany L Mitchell,Anna Monistrol-Mula,Jodi T Thomas et al.
Brittany L Mitchell et al.
Depression is a highly prevalent and disabling condition, with its burden expected to rise significantly by 2050. The heterogeneity of depression is evident in the wide variation of symptom presentations and comorbidities, complicating effo...
Sleep and Mental Health: Unveiling the Critical Role of Sleep in Brain Function and Psychiatric Disorders [0.03%]
睡眠与心理健康：揭示睡眠在大脑功能和精神障碍中的关键作用
Armando D&#x;Agostino,Anna Castelnovo,Giulio Tononi et al.
Armando D&#x;Agostino et al.
Sarah R Anderson,Richard M Jin,Anna V Molofsky
Sarah R Anderson
Neurodevelopmental disorders (NDDs) are characterized by alterations in typical brain development. The immune system is increasingly implicated in NDDs and may contribute to both susceptibility and pathology. Here, we discuss evidence in an...