Transcranial Direct Current Stimulation Improves Paranoia and Social Functioning in Schizophrenia: A Randomized Clinical Trial [0.03%]
经颅直流电刺激改善精神分裂症的偏执状态和社交能力：随机临床试验结果
Linlin Fan,Sara Carrico,Yiyi Zhu et al.
Linlin Fan et al.
Background: Innovative treatments for paranoia, which significantly impairs social functioning in schizophrenia (SCZ), are urgently needed. The pathophysiology of paranoia implicates the amygdala-prefrontal (PFC) circuits...
Alterations in Prefrontal Cortical Somatostatin Neurons in Schizophrenia: Evidence for Weaker Inhibition of Pyramidal Neuron Dendrites [0.03%]
与精神分裂症有关的前额叶皮层生长抑素神经元的变化：证据表明对锥体细胞树突的抑制作用减弱
Samuel J Dienel,Kirsten L Wade,Kenneth N Fish et al.
Samuel J Dienel et al.
Background: Certain cognitive processes require inhibition provided by the somatostatin (SST) class of gamma-aminobutyric acid (GABA) neurons in the dorsolateral prefrontal cortex (DLPFC). This inhibition onto pyramidal n...
Speak and you shall predict: evidence that speech at initial cocaine abstinence is a biomarker of long-term drug use behavior [0.03%]
开口即预言：证据表明初次使用可卡因后的言语是长期药物使用的生物标志物
Carla Agurto,Guillermo Cecchi,Sarah King et al.
Carla Agurto et al.
Background: Valid scalable biomarkers for predicting longitudinal clinical outcomes in psychiatric research are crucial for optimizing intervention and prevention efforts. Here we recorded spontaneous speech from initiall...
Andreas Göteson,Jessica Holmén-Larsson,Hatice Celik et al.
Andreas Göteson et al.
Background: Bipolar disorder (BD) is a severe psychiatric condition with unclear etiology and no established biomarkers. Here, we aimed to characterize the cerebrospinal fluid (CSF) proteome in euthymic BD individuals to ...
Sex Differences in the Striatal Contributions to Longitudinal Fine Motor Development in Autistic Children [0.03%]
自闭症儿童精细运动发育的纹状体脑影像学特征的性别差异研究
Olivia Surgent,Derek S Andrews,Joshua K Lee et al.
Olivia Surgent et al.
Background: Fine motor challenges are prevalent in autistic populations. However, little is known about their neurobiological underpinnings or how their related neural mechanisms are influenced by sex. The dorsal striatum...
Personalized theta-burst stimulation enhances social skills in young minimally verbal children with autism: a double-blind randomized controlled trial [0.03%]
个性化节律刺激可改善自闭症患儿的社会技能：一项双盲随机对照试验
Jinming Xiao,Yating Ming,Lei Li et al.
Jinming Xiao et al.
Background: Minimally verbal children with autism are understudied and lack effective treatment options. Personalized continuous theta-burst stimulation (cTBS) targeting the amygdala and its circuitry may be a potential t...
Focused Ultrasound Neuromodulation: Exploring a Novel Treatment for Severe Opioid Use Disorder [0.03%]
聚焦超声神经调控：探索治疗严重阿片类药物使用障碍的新方法
Ali Rezai,Daisy G Y Thompson-Lake,Pierre-François D&#x;Haese et al.
Ali Rezai et al.
Background: Opioid use disorder remains a critical healthcare challenge as current therapeutic strategies have limitations resulting in high recurrence and deaths. We evaluated safety and feasibility of focused ultrasound...
The genetic architecture of differentiating behavioral and emotional problems in early life [0.03%]
遗传架构在生命早期行为和情感问题的分化中的作用
Adrian Dahl Askelund,Laura Hegemann,Andrea G Allegrini et al.
Adrian Dahl Askelund et al.
Background: Early in life, behavioral and cognitive traits associated with risk for developing a psychiatric condition are broad and undifferentiated. As children develop, these traits differentiate into characteristic cl...
The Dark Side of Empathy: the Role of Excessive Affective Empathy on Mental Health Disorders [0.03%]
共情的阴暗面——过度的情绪性共情对精神疾病的作用
Chaoli Huang,Zifeng Wu,Sha Sha et al.
Chaoli Huang et al.
Empathy, typically regarded as a positive attribute, is now being critically evaluated for its potential negative implications on mental health. A growing body of research indicates that excessive empathy, particularly high level of affecti...