Navigating Neuroimaging Challenges in Rare Neurogenetic Disorders: A Case Example From Girls With Fragile X Syndrome [0.03%]
罕见神经遗传障碍的神经影像挑战及应对策略——来自脆性X综合征女孩的一个病例研究
Lauren M Schmitt,Elizabeth G Smith
Lauren M Schmitt
Sarah D Lichenstein,Brian D Kiluk,Marc N Potenza et al.
Sarah D Lichenstein et al.
Background: Cannabis use is common, particularly during emerging adulthood when brain development is ongoing, and its use is associated with harmful outcomes for a subset of people. An improved understanding of the neural...
Kenta Asahina,Moriel Zelikowsky
Kenta Asahina
Chronic social isolation alters behavior across animal species. Genetic model organisms such as mice and flies provide crucial insight into the molecular and physiological effects of social isolation on brain cells and circuits. Here, we co...
Interneuron loss and microglia activation by transcriptome analyses in the basal ganglia of Tourette disorder [0.03%]
基底神经节中图雷特障碍的转录组分析显示了中间神经元丢失和小胶质细胞活化现象
Yifan Wang,Liana Fasching,Feinan Wu et al.
Yifan Wang et al.
Background: Tourette disorder is characterized by motor hyperactivity and tics that are believed to originate in basal ganglia. Postmortem immunocytochemical analyses previously revealed decreases in cholinergic, parvalbu...
Investigating the contribution of coding variants in alcohol use disorder using whole-exome sequencing across ancestries [0.03%]
利用全外显子组测序跨谱系研究编码变异在酒精使用障碍中的作用
Lu Wang,Henry R Kranzler,Joel Gelernter et al.
Lu Wang et al.
Background: Alcohol use disorder (AUD) is a leading cause of death and disability worldwide. There has been substantial progress in identifying genetic variants underlying AUD. However, whole-exome sequencing (WES) studie...
Two-Month Cognitive Changes Enhance Prediction of Non-Remission in Clinical High-Risk Individuals [0.03%]
两个月的认知变化增强对临床高危个体非缓解性的预测能力
TianHong Zhang,YanYan Wei,XiaoChen Tang et al.
TianHong Zhang et al.
Background: Longitudinal changes in cognitive function may be crucial in predicting clinical outcomes in clinical high risk (CHR) individuals. This study aims to investigate the predictive value of baseline cognitive impa...
Hippocampal DNA methylation promotes contextual fear memory persistence by facilitating systems consolidation and cortical engram stabilization [0.03%]
海马DNA甲基化通过促进系统巩固和皮层记忆痕迹的稳定来促进情境恐惧记忆的持久性
Janina Kupke,Stefanos Loizou,C Peter Bengtson et al.
Janina Kupke et al.
Background: Long-term fear memory storage involves gradual reorganization of supporting brain regions over time, a process termed systems consolidation. Memories initially rely on the hippocampus but gradually shift depen...
Nuclear calcium signaling in D1 receptor-expressing neurons of the nucleus accumbens regulates molecular, cellular and behavioral adaptations to cocaine [0.03%]
伏隔核D1受体神经元的核内钙信号调节可卡因引起的分子、细胞和行为适应性反应
Estefani Saint-Jour,Marie-Charlotte Allichon,Andry Andrianarivelo et al.
Estefani Saint-Jour et al.
Background: The persistence of cocaine-evoked adaptations relies on gene regulations within the reward circuit, especially in the ventral striatum (i.e., nucleus accumbens (NAc)). Notably, activation of the extracellular ...
Grasping Post-Traumatic Stress Disorder (PTSD) from the Perspective of Psychoneuroimmunoendocrinology (PNIE): Etiopathogenic Mechanisms and Relevance for the Integrative Management [0.03%]
从心理神经免疫内分泌学角度理解创伤后应激障碍：病因及整合治疗的相关性
Oscar Fraile-Martinez,Cielo García-Montero,Miguel Ángel Álvarez-Mon et al.
Oscar Fraile-Martinez et al.
Post-Traumatic Stress Disorder (PTSD) is a debilitating condition caused by exposure to traumatic events, affecting 5-10% of the population, with increased prevalence among women and individuals in war zones. Beyond psychological symptoms, ...
Characterizing brainstem glucagon-like peptide-1 control of sensory-specific-satiety in male and female rats across the estrous cycle [0.03%]
脑干糖依赖性肠肽对雄性和雌性大鼠发情周期感觉特异性饱腹感的控制作用特征
Sarah V Applebey,Allison G Xiao,Erin P Harris et al.
Sarah V Applebey et al.
Background: Meal variety promotes overconsumption by delaying sensory-specific-satiety (SSS), the transient reduction in reward value of a recently consumed food. Despite its role in meal cessation, the neuroendocrine mec...