Effects of the KCNQ (Kv7) Channel Opener Ezogabine on Resting-State Functional Connectivity of Striatal Brain Reward Regions, Depression and Anhedonia in Major Depressive Disorder: Results from a Randomized Controlled Trial [0.03%]
KCNQ（Kv7）通道开放剂Ezogabine对主要抑郁症患者的纹状体脑奖赏区的静息态功能连接，抑郁和快感丧失的影响：随机对照试验的结果
Avijit Chowdhury,Sarah Boukezzi,Sara Costi et al.
Avijit Chowdhury et al.
Background: Major depressive disorder (MDD) is a leading cause of disability worldwide, with available treatments often showing limited efficacy. Recent research suggests targeting specific subtypes of depression and unde...
Integrative genomics approach identifies glial transcriptomic dysregulation and risk in the cortex of individuals with Alcohol Use Disorder [0.03%]
整合基因组学方法识别酒精使用障碍个体皮层中的胶质转录组失调和风险
Anna S Warden,Nihal A Salem,Eric Brenner et al.
Anna S Warden et al.
Background: Alcohol use disorder (AUD) is a prevalent neuropsychiatric disorder that is a major global health concern, affecting millions of people worldwide. Past studies of AUD used underpowered single cell analysis or ...
Amygdala hyperactivity in PTSD: disentangling predisposing from consequential factors in a prospective longitudinal design [0.03%]
PTSD中的杏仁核高活动性：在前瞻性纵向设计中区分易感和后果因素
Lycia D de Voogd,Mahur M Hashemi,Wei Zhang et al.
Lycia D de Voogd et al.
Background: Substantial inter-individual differences exist in the vulnerability to develop post-traumatic stress disorder (PTSD) symptoms following trauma exposure. Identification of neurocognitive risk markers for PTSD-s...
Emergence and dynamics of delusions and hallucinations across stages in early psychosis [0.03%]
早期精神病各阶段妄想和幻觉的出现及其动态变化
Catalina Mourgues-Codern,David Benrimoh,Jay Gandhi et al.
Catalina Mourgues-Codern et al.
Background: Hallucinations and delusions are often grouped together within the positive symptoms of psychosis. However, recent evidence suggests they may be driven by distinct computational and neural mechanisms. Examinin...
Dissecting Schizophrenia Biology Using Pleiotropy with Cognitive Genomics [0.03%]
利用认知基因组学与等位基因分析精神分裂症生物学特性
Upasana Bhattacharyya,Jibin John,Todd Lencz et al.
Upasana Bhattacharyya et al.
Background: Given the increasingly large number of loci discovered by psychiatric GWAS, specification of the key biological pathways underlying these loci has become a priority for the field. We have previously leveraged ...
The Neuropsychiatric Checklist for Autoimmune Psychosis: A Narrative Review [0.03%]
自身免疫性精神病的神经精神检查表：一项叙述性综述
Ludger Tebartz van Elst,Kimon Runge,Philipp T Meyer et al.
Ludger Tebartz van Elst et al.
Autoimmune encephalitis is a rapidly evolving topic in both neurology and psychiatry. A recent international consensus paper defined criteria for possible, probable and definite autoimmune psychosis (AP) inspired by the principles establish...
Neurobiological perturbations in bipolar disorder compared to schizophrenia - evidence from cell cultures and brain organoids [0.03%]
与精神分裂症相比，双相障碍中的神经生物学扰动-来自细胞培养和脑类器官的证据
Ibrahim A Akkouh,Jordi Requena Osete,Attila Szabo et al.
Ibrahim A Akkouh et al.
Bipolar disorder (BD) and schizophrenia (SCZ) are uniquely human disorders with a complex pathophysiology which involves adverse neuropathological events in brain development. High disease polygenicity and limited access to live human brain...
Mapping the genetic landscape of psychiatric disorders with the MiXeR toolset [0.03%]
利用MiXeR工具绘制精神障碍的遗传图谱
Dennis van der Meer,Guy Hindley,A Shadrin et al.
Dennis van der Meer et al.
Psychiatric disorders have complex genetic architectures with substantial genetic overlap across conditions, which may partly explain their high levels of comorbidity. This presents significant challenges to research; genome-wide associatio...
Reply to: Methodological and Interpretational Issues in PsyRiskMR Database [0.03%]
《关于PsyRiskMR数据库的方法论和解释问题的回复》
Xiaoyan Li,Junfeng Xia
Xiaoyan Li
Incorporating polygenic liability and family history for predicting psychiatric diseases in the Taiwan biobank [0.03%]
在台湾生物银行中结合多基因易感性和家族史来预测精神疾病
Shi-Heng Wang,Yen-Chen A Feng,Mei-Chen Lin et al.
Shi-Heng Wang et al.
Background: This study investigated the interplay between molecular measures of polygenic risk score (PRS) and conventional measures of family history (FH) on the risk of four psychiatric disorders: schizophrenia (SCZ), b...